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Cellosaurus TE 159.T (CVCL_1743)

[Text version]
Cell line name TE 159.T
Synonyms TE-159-T; TE159T
Accession CVCL_1743
Resource Identification Initiative To cite this cell line use: TE 159.T (RRID:CVCL_1743)
Comments Problematic cell line: Misclassified. Originally thought to be a rhabdomyosarcoma cell line but using a variety of omics methods was shown to be a a fibroblastic cell line (DOI=10.1101/166199; DepMap=ACH-000175).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: Caucasian.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Cell type: Fibroblast; CL=CL_0000057.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=12068308).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175Leu (c.524G>T); ClinVar=VCV000182963; Zygosity=Unspecified (DepMap=ACH-000175).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,11:01
HLA-BB*15:01,52:01
HLA-CC*04:01,12:02
Class II
HLA-DRDRB1*01:03,15:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.8
Native American21.64
East Asian, North2.4
East Asian, South0
South Asian1.76
European, North45.27
European, South27.14
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 6Y
Category Undefined cell line type
STR profile Source(s): ATCC=CRL-7752

Markers:
AmelogeninX,Y
CSF1PO12,13
D2S133819,23
D3S135814,15
D5S8189,11
D7S82010,11
D8S117912,15
D13S31712,14
D16S5399,11
D18S5116,21
D19S43313
D21S1128,30
FGA23
Penta D10
Penta E12,16
TH016,9.3
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=12068308; DOI=10.1038/nature00766
Davies H., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

DOI=10.1101/166199
de Weck A., Bitter H., Kauffmann A.
Fibroblasts cell lines misclassified as cancer cell lines.
bioRxiv 2017:166199-166199(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-7752
Cell line databases/resources CLO; CLO_0009292
cancercelllines; CVCL_1743
Cell_Model_Passport; SIDM01761
DepMap; ACH-000175
Biological sample resources BioSample; SAMN03471147
BioSample; SAMN10988169
Chemistry resources PharmacoDB; TE159_T_1572_2019
Encyclopedic resources Wikidata; Q54971953
Gene expression databases ArrayExpress; E-MTAB-2770
Polymorphism and mutation databases Cosmic; 686755
IARC_TP53; 30179
LiGeA; CCLE_329
Progenetix; CVCL_1743
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number24