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Cellosaurus TC-YIK (CVCL_1737)

[Text version]

Cell line name TC-YIK
Synonyms TCYIK
Accession CVCL_1737
Resource Identification Initiative To cite this cell line use: TC-YIK (RRID:CVCL_1737)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Characteristics: Established from the YIK-1 xenograft which was obtained by mutliple serial transplantation of the original tumor in nude mice.
Doubling time: ~21.6 hours, at 119th passage (PubMed=1849445).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations
  • Mutation; HGNC; 9885; ARID4A; Simple; p.Glu565Ter (c.1693G>T); Zygosity=Heterozygous (Cosmic-CLP; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North74.47
East Asian, South25.52
South Asian0
European, North0
European, South0
Disease Cervical small cell neuroendocrine carcinoma (NCIt: C7982)
High-grade neuroendocrine carcinoma of the cervix uteri (ORDO: Orphanet_213777)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 31Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; RCB


Run an STR similarity search on this cell line

PubMed=1849445; DOI=10.1002/1097-0142(19910501)67:9<2327::AID-CNCR2820670919>3.0.CO;2-F
Ichimura H., Yamasaki M., Tamura I., Katsumoto T., Sawada M., Kurimura O., Furuyama J.-I., Kurimura T.
Establishment and characterization of a new cell line TC-YIK originating from argyrophil small cell carcinoma of the uterine cervix integrating HPV16 DNA.
Cancer 67:2327-2332(1991)

PubMed=10391092; DOI=10.1111/j.1349-7006.1999.tb00779.x
Ichimura H., Sakashita N., Iida T., Chisaka T., Yasuda H., Kita M., Yuasa S., Imanishi J.
Differentiation of a cell line of human cervical argyrophil small cell carcinoma to macrophage lineage cells.
Jpn. J. Cancer Res. 90:523-529(1999)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections RCB; RCB0443
Cell line databases/resources CLO; CLO_0050913
Cell_Model_Passport; SIDM00234
Cosmic-CLP; 946357
DepMap; ACH-002201
Biological sample resources BioSample; SAMN03472316
Chemistry resources ChEMBL-Cells; CHEMBL3308250
ChEMBL-Targets; CHEMBL2366324
GDSC; 946357
PharmacoDB; TCYIK_1568_2019
Encyclopedic resources Wikidata; Q54971829
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670527
Polymorphism and mutation databases Cosmic; 946357
Cosmic; 1995659
IARC_TP53; 27258
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update16-Dec-2021
Version number26