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Cellosaurus SW954 (CVCL_1732)

[Text version]

Cell line name SW954
Synonyms SW-954; SW 954
Accession CVCL_1732
Resource Identification Initiative To cite this cell line use: SW954 (RRID:CVCL_1732)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
From: Scott and White Clinic; Temple; USA.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg158His (c.473G>A); ClinVar=VCV000141963; Zygosity=Homozygous (Cosmic-CLP; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.24
Native American0
East Asian, North0.14
East Asian, South0.57
South Asian1.33
European, North70.36
European, South27.38
Disease Vulvar squamous cell carcinoma (NCIt: C4052)
Vulvar squamous cell carcinoma (ORDO: Orphanet_494448)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 86Y
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP; DepMap

Markers:
AmelogeninX
CSF1PO10,11
D3S135816
D5S81811,12
D7S82011,13
D8S117910,13
D13S3179,11
D16S53911
D18S5120
D21S1130,31
FGA23
Penta D12,13
Penta E9,14
TH018,9.3
TPOX8
vWA14,15

Run an STR similarity search on this cell line
Publications

PubMed=924690; DOI=10.1002/ijc.2910200505
Kerbel R.S., Pross H.F., Leibovitz A.
Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors.
Int. J. Cancer 20:673-679(1977)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections ATCC; HTB-117
Cell line databases/resources CLO; CLO_0009204
Cell_Model_Passport; SIDM01157
Cosmic-CLP; 924247
DepMap; ACH-001400
IGRhCellID; SW954
LINCS_LDP; LCL-1295
Biological sample resources BioSample; SAMN03471097
Chemistry resources ChEMBL-Cells; CHEMBL3307461
ChEMBL-Targets; CHEMBL614943
GDSC; 924247
PharmacoDB; SW954_1550_2019
PubChem_Cell_line; CVCL_1732
Encyclopedic resources Wikidata; Q54971219
Experimental variables resources EFO; EFO_0002376
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670517
Polymorphism and mutation databases Cosmic; 924247
IARC_TP53; 27255
Progenetix; CVCL_1732
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update15-Dec-2022
Version number31