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Cellosaurus SW872 (CVCL_1730)

[Text version]
Cell line name SW872
Synonyms SW-872; SW 872
Accession CVCL_1730
Resource Identification Initiative To cite this cell line use: SW872 (RRID:CVCL_1730)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
From: Scott and White Clinic; Temple; USA.
Population: Caucasian.
Doubling time: 24 hours (PubMed=16888811).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Misspelling: SW672; PubMed=17431109.
Sequence variations
  • Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Homozygous (ATCC=HTB-92).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=12068308; PubMed=26643872; ATCC=HTB-92; Cosmic-CLP=909756; DepMap=ACH-002310).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (PubMed=26643872; ATCC=HTB-92; Cosmic-CLP=909756; DepMap=ACH-002310).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile251Asn (c.752T>A); ClinVar=VCV000528254; Zygosity=Homozygous (PubMed=16888811; PubMed=26643872; Cosmic-CLP=909756; DepMap=ACH-002310).
HLA typing Source: CLS=300405
Class I
HLA-AA*02:01:01G
HLA-BB*27:05:02,40:01:02
HLA-CC*01:02:01,03:04:01
Class II
HLA-DPDPB1*02:01:02
HLA-DQDQA1*04:01:01,05:05:01
DQB1*03:01:01,04:02:01
HLA-DRDRB1*08:01:01;13:03:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.25
Native American0
East Asian, North2.4
East Asian, South0.14
South Asian1.73
European, North69.64
European, South24.84
Disease Liposarcoma (NCIt: C3194)
Liposarcoma (ORDO: Orphanet_69078)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 36Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-92; CLS=300405; Cosmic-CLP=909756

Markers:
AmelogeninX
CSF1PO10
D2S133817,21
D3S135816
D5S81812,13
D7S8208,11
D8S117912,15
D13S31711
D16S5399,12
D18S5112,16
D19S43313,14
D21S1127,31.2
FGA21.2,23
Penta D9,10
Penta E5,10
TH018,10
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=327080; DOI=10.1093/jnci/59.1.221
Jorgen Fogh, Jens M. Fogh, Thomas Orfeo;
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6220172
Nicholas C. Dracopoli, Jorgen Fogh;
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=16888811; DOI=10.1002/jcb.21073
Victoria Moneo, Beatriz G. Serelde, Jesus Maria Fominaya, Juan Fernando Martinez-Leal, Carmen Blanco-Aparicio, Lourdes Romero, Margarita Sanchez-Beato, Juan Cruz Cigudosa, Juan C. Tercero, Miguel Angel Piris, Jose Maria Jimeno, Amancio Carnero;
Extreme sensitivity to Yondelis (Trabectedin, ET-743) in low passaged sarcoma cell lines correlates with mutated p53.
J. Cell. Biochem. 100:339-348(2007)

PubMed=17354236; DOI=10.1002/ijc.22643
Christoph R. Muller, Erik B. Paulsen, Paul Noordhuis, Florence Pedeutour, Gunnar Saeter, Ola Myklebost;
Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A.
Int. J. Cancer 121:199-205(2007)

PubMed=17426441; DOI=10.4161/cbt.6.4.3816
Elizabeth W. LaPensee, Shamantha P. Reddy, Eric R. Hugo, Sandy J. Schwemberger, Nira Ben-Jonathan;
LS14 cells: a model for chemoresistance in liposarcoma.
Cancer Biol. Ther. 6:519-524(2007)

PubMed=17431109; DOI=10.1158/1535-7163.MCT-06-0729
Victoria Moneo, Beatriz G. Serelde, Juan F.M. Leal, Carmen Blanco-Aparicio, Ramon Diaz-Uriarte, Miguel Aracil, Juan C. Tercero, Jose Maria Jimeno, Amancio Carnero;
Levels of p27(kip1) determine Aplidin sensitivity.
Mol. Cancer Ther. 6:1310-1316(2007)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22911243; DOI=10.1155/2012/148614; PMCID=PMC3403520
Eva Wessel Stratford, Russell Castro, Jeanette Daffinrud, Magne Skarn, Silje Lauvrak, Else Munthe, Ola Myklebost;
Characterization of liposarcoma cell lines for preclinical and biological studies.
Sarcoma 2012:148614.1-148614.9(2012)

PubMed=24726063; DOI=10.1186/1756-9966-33-33; PMCID=PMC4022359
Christian Koelsche, Marcus Renner, Wolfgang Hartmann, Regine Brandt, Burkhard Lehner, Nina Waldburger, Ingo Alldinger, Thomas Schmitt, Gerlinde Egerer, Roland Penzel, Eva Wardelmann ...Show all 14 authors... , Peter Schirmacher, Andreas von Deimling, Gunhild Mechtersheimer; Show fewer authors
TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities.
J. Exp. Clin. Cancer Res. 33:33.1-33.8(2014)

PubMed=24758355; DOI=10.1186/1471-2407-14-281; PMCID=PMC4023704
Victoria Moneo, Beatriz G. Serelde, Carmen Blanco-Aparicio, Ramon Diaz-Uriarte, Pablo Aviles, Gemma Santamaria, Juan C. Tercero, Carmen Cuevas, Amancio Carnero;
Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis.
BMC Cancer 14:281.1-281.10(2014)

PubMed=26643872; DOI=10.18632/oncotarget.6464; PMCID=PMC4767443
Deepika Kanojia, Yasunobu Nagata, Manoj Garg, Dhong Hyun Lee, Aiko Sato, Kenichi Yoshida, Yusuke Sato, Masashi Sanada, Anand Mayakonda, Christoph Bartenhagen, Hans-Ulrich Klein ...Show all 28 authors... , Ngan B. Doan, Jonathan William Said, S. Mohith, Swetha Gunasekar, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Ola Myklebost, Henry He Yang, Martin Dugas, Leonardo Andres Meza-Zepeda, Allan W. Silberman, Charles Forscher, Jeffrey W. Tyner, Seishi Ogawa, Harold Phillip Koeffler; Show fewer authors
Genomic landscape of liposarcoma.
Oncotarget 6:42429-42444(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; HTB-92
BCRC; 60432
CLS; 300405
IZSLER; BS TCL 119
NCBI_Iran; C638
Cell line databases/resources CLO; CLO_0009201
CLO; CLO_0037071
cancercelllines; CVCL_1730
Cell_Model_Passport; SIDM01159
Cosmic-CLP; 909756
DepMap; ACH-002310
IGRhCellID; SW872
LINCS_LDP; LCL-1459
Lonza; 88
Anatomy/cell type resources BTO; BTO_0003743
Biological sample resources BioSample; SAMN03472763
Chemistry resources ChEMBL-Cells; CHEMBL3308837
ChEMBL-Targets; CHEMBL2366302
GDSC; 909756
PharmacoDB; SW872_1547_2019
PubChem_Cell_line; CVCL_1730
Encyclopedic resources Wikidata; Q54971215
Experimental variables resources EFO; EFO_0002373
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10726-110A6
GEO; GSM185156
GEO; GSM185157
GEO; GSM482514
GEO; GSM1543668
GEO; GSM1543669
GEO; GSM1670514
Polymorphism and mutation databases Cosmic; 684521
Cosmic; 909756
Cosmic; 923383
Cosmic; 2009544
Cosmic; 2307722
Cosmic; 2560246
Cosmic; 2800532
IARC_TP53; 24518
Progenetix; CVCL_1730
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number42