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Cellosaurus SKG-IIIa (CVCL_1704)

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Cell line name SKG-IIIa
Synonyms SKG-IIIA; SKG IIIa; SKGIIIA; SKG-3a; SKG3A; SKG3a
Accession CVCL_1704
Resource Identification Initiative To cite this cell line use: SKG-IIIa (RRID:CVCL_1704)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Asn (c.396G>C); ClinVar=VCV000376624; Zygosity=Heterozygous (Cosmic-CLP=930298; DepMap=ACH-002020).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.18
Native American0
East Asian, North84.88
East Asian, South14.94
South Asian0
European, North0
European, South0
Disease Human papillomavirus-related cervical squamous cell carcinoma (NCIt: C27676)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2795 ! SKG-IIIb
Sex of cell Female
Age at sampling 38Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=930298; JCRB=IFO50310; JCRB=JCRB0232; PubMed=25877200; RCB=RCB1892; TKG=TKG 0462

Markers:
AmelogeninX
CSF1PO11,12
D2S133819,26
D3S135816
D5S81810,11
D7S82010 (JCRB=JCRB0232)
10,12 (Cosmic-CLP=930298; PubMed=25877200; JCRB=IFO50310; RCB=RCB1892; TKG=TKG 0462)
D8S117911,15
D13S31712
D16S5399,11
D18S5116
D19S43313
D21S1131.2,32.2
FGA21,22
Penta D9
Penta E10
TH016,9
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=6600963
Shiro Nozawa, Yasuhiro Udagawa, Hiroaki Ohta, Soju Kurihara, William Harold Fishman;
Newly established uterine cervical cancer cell line (SKG-III) with Regan isoenzyme, human chorionic gonadotropin beta-subunit, and pregnancy-specific beta 1-glycoprotein phenotypes.
Cancer Res. 43:1748-1760(1983)

PubMed=6699456
Yasuhiro Udagawa, Shiro Nozawa, Katsumi Tsukazaki, Hiroaki Ohta, Takuma Akiba, Soju Kurihara;
Biological properties of two newly established cell lines (SKG-3a,3b) from a human uterine cervical epidermoid carcinoma.
Nihon Sanka Fujinka Gakkai Zasshi 36:237-246(1984)

PubMed=8380785; DOI=10.1006/gyno.1993.1016
Tsuyoshi Iwasaka, Mamoru Oh-uchida, Norihito Matsuo, Masatoshi Yokoyama, Kouichi Fukuda, Kouichi Hara, Kouzo Fukuyama, Katsuji Hori, Hajime Sugimori;
Correlation between HPV positivity and state of the p53 gene in cervical carcinoma cell lines.
Gynecol. Oncol. 48:104-109(1993)

CLPUB00481
Haruhiko Kuno, Touho Yoshida;
Detection of human papillomavirus types 16, 18, and 33 in cell lines derived from human genital organs by polymerase chain reaction.
Res. Commun. Inst. Ferment. 18:6-12(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=15099960; DOI=10.1016/j.ygyno.2004.02.012
Takashi Fujimoto, Akira Nishikawa, Masahiro Iwasaki, Noriyuki Akutagawa, Mizue Teramoto, Ryuichi Kudo;
Gene expression profiling in two morphologically different uterine cervical carcinoma cell lines derived from a single donor using a human cancer cDNA array.
Gynecol. Oncol. 93:446-453(2004)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35692560; DOI=10.1080/23723556.2022.2078628; PMCID=PMC9176225
Ma de Lourdes Zuniga-Martinez, Carlos Miguel Lopez-Mendoza, Jared Tenorio-Salazar, Alejandro Manuel Garcia-Carranca, Marco Antonio Cerbon-Cervantes, Luz Eugenia Alcantara-Quintana;
Establishment, authenticity, and characterization of cervical cancer cell lines.
Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; IFO50310
JCRB; JCRB0232
RCB; RCB1892
TKG; TKG 0462
Cell line databases/resources CLO; CLO_0050923
cancercelllines; CVCL_1704
Cell_Model_Passport; SIDM00381
Cosmic-CLP; 930298
DepMap; ACH-002020
LINCS_LDP; LCL-1804
Biological sample resources BioSample; SAMN01821739
BioSample; SAMN03470894
BioSample; SAMN03471660
Chemistry resources ChEMBL-Cells; CHEMBL3308786
ChEMBL-Targets; CHEMBL1075581
GDSC; 930298
PharmacoDB; SKGIIIa_1417_2019
PubChem_Cell_line; CVCL_1704
Encyclopedic resources Wikidata; Q54954734
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670429
Polymorphism and mutation databases Cosmic; 877461
Cosmic; 930298
Cosmic; 1152539
Cosmic; 1995630
IARC_TP53; 27576
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number39