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Cellosaurus SCH (CVCL_1687)

[Text version]
Cell line name SCH
Accession CVCL_1687
Resource Identification Initiative To cite this cell line use: SCH (RRID:CVCL_1687)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 54 hours (CelloPub=CLPUB00142); 36-37 hours (CelloPub=CLPUB00584); ~1.5 days (lot 07022010) (JCRB).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg249dup (c.745_747dupAGG) (p.Arg249_Pro250insArg) (c.747_748insAGG); Zygosity=Heterozygous (PubMed=7819056; Cosmic-CLP; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North77.74
East Asian, South22.24
South Asian0.01
European, North0
European, South0
Disease Gastric choriocarcinoma (NCIt: C95749)
Derived from metastatic site: Omentum.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB


Run an STR similarity search on this cell line

Kameya T., Kuramoto H., Suzuki K., Kenjo T., Oshikiri T., Hayashi H., Itakura M.
A human gastric choriocarcinoma cell line with human chorionic gonadotropin and placental alkaline phosphatase production.
Cancer Res. 35:2025-2032(1975)

Motoya T., Hojo H., Suzuki T., Oboshi S.
Evaluation of the regrowth assay method as an in vitro drug sensitivity test and its application to cultured human gastric cancer cell lines.
Acta Med. Biol. 27:49-63(1979)

Tanaka K., Takeuchi S.
Cell culture of choriocarcinoma.
Tissue Cult. 6:471-478(1980)

Tanaka K.
Establishment and characterisation of cultured cell lines of human choriocarcinoma origin.
Niigata Igakkai Zasshi 95:95-105(1981)

PubMed=6682628; DOI=10.1016/0002-9378(83)90927-4
Sekiya S., Kaiho T., Shirotake S., Iwasawa H., Takeda B., Takamizawa H.
Effect of methotrexate on the growth and human chorionic gonadotropin secretion of human choriocarcinoma cell lines in vitro.
Am. J. Obstet. Gynecol. 146:57-64(1983)

PubMed=2878840; DOI=10.1016/0020-7292(86)90088-3
Yamashita K., Nakamura T., Shimizu T., Katagiri M., Ikeda H.
Expression of HLA class I and class II antigens in human choriocarcinoma cell lines.
Int. J. Gynecol. Obstet. 24:301-307(1986)

PubMed=7819056; DOI=10.1038/bjc.1995.3
Yaginuma Y., Yamashita T., Takuma N., Katayama H., Ishikawa M.
Analysis of the p53 gene in human choriocarcinoma cell lines.
Br. J. Cancer 71:9-12(1995)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

Ganapathy V., Prasad P.D., Leibach F.H.
(In) Human cell culture. Vol. 2. Cancer Cell Lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.141-147; Kluwer Academic Publishers; New York (1999)

PubMed=11014955; DOI=10.1159/000010310
Takayanagi T., Aoki Y., Tanaka K.
Expression of constitutively active c-MET receptor in human choriocarcinoma.
Gynecol. Obstet. Invest. 50:198-202(2000)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cell line collections JCRB; JCRB0251
Cell line databases/resources Cell_Model_Passport; SIDM00383
Cosmic-CLP; 909711
DepMap; ACH-002198
Anatomy/cell type resources BTO; BTO:0005929
Biological sample resources BioSample; SAMN03471666
Chemistry resources ChEMBL-Cells; CHEMBL3308783
ChEMBL-Targets; CHEMBL1075573
GDSC; 909711
PharmacoDB; SCH_1359_2019
PubChem_Cell_line; CVCL_1687
Encyclopedic resources Wikidata; Q54952424
Experimental variables resources EFO; EFO_0002856
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM552371
GEO; GSM562417
GEO; GSM827269
GEO; GSM1670414
Polymorphism and mutation databases Cosmic; 801343
Cosmic; 909711
Cosmic; 1187290
IARC_TP53; 4347
Progenetix; CVCL_1687
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update21-Mar-2023
Version number33