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Cellosaurus SCH (CVCL_1687)

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Cell line name SCH
Accession CVCL_1687
Resource Identification Initiative To cite this cell line use: SCH (RRID:CVCL_1687)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 54 hours (CelloPub=CLPUB00142); 36-37 hours (CelloPub=CLPUB00584); ~1.5 days (Note=Lot 07022010) (JCRB=JCRB0251).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Omentum; UBERON=UBERON_0003688.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg249dup (c.745_747dupAGG) (p.Arg249_Pro250insArg) (c.747_748insAGG); Zygosity=Heterozygous (PubMed=7819056; Cosmic-CLP=909711; DepMap=ACH-002198).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North77.74
East Asian, South22.24
South Asian0.01
European, North0
European, South0
Disease Gastric choriocarcinoma (NCIt: C95749)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=909711; JCRB=JCRB0251

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81811
D7S82010,11
D13S31711,12
D16S5399
TH016,7
TPOX11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=1170940
Toru Kameya, Hiroyuki Kuramoto, Kenji Suzuki, Takiko Kenjo, Teruyuki Oshikiri, Hiroatsu Hayashi, Motoyoshi Itakura;
A human gastric choriocarcinoma cell line with human chorionic gonadotropin and placental alkaline phosphatase production.
Cancer Res. 35:2025-2032(1975)

CLPUB00584
Teiichi Motoyama, Haruto Hojo, Toshimitsu Suzuki, Shoichi Oboshi;
Evaluation of the regrowth assay method as an in vitro drug sensitivity test and its application to cultured human gastric cancer cell lines.
Acta Med. Biol. 27:49-63(1979)

CLPUB00142
Kenichi Tanaka, Shoshichi Takeuchi;
Cell culture of choriocarcinoma.
Tissue Cult. 6:471-478(1980)

CLPUB00141
Kenichi Tanaka;
Establishment and characterisation of cultured cell lines of human choriocarcinoma origin.
Niigata Igakkai Zasshi 95:95-105(1981)

PubMed=6682628; DOI=10.1016/0002-9378(83)90927-4
Souei Sekiya, Teruyo Kaiho, Syoichi Shirotake, Hiroshi Iwasawa, Bin Takeda, Hiroyoshi Takamizawa;
Effect of methotrexate on the growth and human chorionic gonadotropin secretion of human choriocarcinoma cell lines in vitro.
Am. J. Obstet. Gynecol. 146:57-64(1983)

PubMed=2878840; DOI=10.1016/0020-7292(86)90088-3
Kohki Yamashita, Takafumi Nakamura, Tetsuya Shimizu, Makoto Katagiri, Hisami Ikeda;
Expression of HLA class I and class II antigens in human choriocarcinoma cell lines.
Int. J. Gynaecol. Obstet. 24:301-307(1986)

PubMed=7819056; DOI=10.1038/bjc.1995.3; PMCID=PMC2033447
Yuji Yaginuma, Tsuyoshi Yamashita, Naoyuki Takuma, Hideto Katayama, Mutsuo Ishikawa;
Analysis of the p53 gene in human choriocarcinoma cell lines.
Br. J. Cancer 71:9-12(1995)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

DOI=10.1007/0-306-46861-1_8
Vadivel Ganapathy, Puttur D. Prasad, Frederick H. Leibach;
Choriocarcinoma.
(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.141-147; Kluwer Academic Publishers; New York; USA (1999)

PubMed=11014955; DOI=10.1159/000010310
Takeshi Takayanagi, Yoichi Aoki, Kenichi Tanaka;
Expression of constitutively active c-MET receptor in human choriocarcinoma.
Gynecol. Obstet. Invest. 50:198-202(2000)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25343454; DOI=10.1371/journal.pone.0111146; PMCID=PMC4208810
Meng-Ling Choong, Shan-Ho Tan, Tuan-Zea Tan, Sravanthy Manesh, Anna Ngo, Jacklyn W.-Y. Yong, Henry He Yang, May Ann Lee;
Molecular integrative clustering of Asian gastric cell lines revealed two distinct chemosensitivity clusters.
PLoS ONE 9:e111146.1-e111146.9(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB0251
Cell line databases/resources CLO; CLO_0037148
cancercelllines; CVCL_1687
Cell_Model_Passport; SIDM00383
Cosmic-CLP; 909711
DepMap; ACH-002198
LINCS_LDP; LCL-1148
Anatomy/cell type resources BTO; BTO_0005929
Biological sample resources BioSample; SAMN03471666
CRISP screens repositories BioGRID_ORCS_Cell_line; 1008
Chemistry resources ChEMBL-Cells; CHEMBL3308783
ChEMBL-Targets; CHEMBL1075573
GDSC; 909711
PharmacoDB; SCH_1359_2019
PubChem_Cell_line; CVCL_1687
Encyclopedic resources Wikidata; Q54952424
Experimental variables resources EFO; EFO_0002856
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10785-110H2
GEO; GSM552371
GEO; GSM562417
GEO; GSM827269
GEO; GSM1670414
Polymorphism and mutation databases Cosmic; 801343
Cosmic; 909711
Cosmic; 1187290
IARC_TP53; 4347
Progenetix; CVCL_1687
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number40