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Cellosaurus SBC-5 (CVCL_1679)

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Cell line name SBC-5
Synonyms SBC5
Accession CVCL_1679
Resource Identification Initiative To cite this cell line use: SBC-5 (RRID:CVCL_1679)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 24 hours (DOI=10.4044/joma1947.104.9-10_905); 31.6 hours (PubMed=8286010); ~40 hours (Note=Lot 111898), 21 hours (Note=Lot 08082007), ~21 hours (Note=Lot 09142018) (JCRB=JCRB0819).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Caution: Originally classified as originating from a lung small cell carcinoma, but is reclassified as a thoracic SMARCA4-deficient undifferentiated tumor based on a number of criteria (PubMed=38180245).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Val82_Glu88del (c.245_265del); Zygosity=Homozygous (PubMed=9673367; DepMap=ACH-000670).
  • Mutation; HGNC; HGNC:2901; DLG2; Unexplicit; Ex7-9del; Zygosity=Homozygous (PubMed=20215515).
  • Mutation; HGNC; HGNC:11100; SMARCA4; Simple; p.Ala1245Leufs*13 (c.3733_3734del); Zygosity=Homozygous (DepMap=ACH-000670).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Homozygous (PubMed=8263009; PubMed=10536175; Cosmic-CLP=713880; DepMap=ACH-000670).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:07,33:03
HLA-BB*46:01,58:01
HLA-CC*01:02,03:02
Class II
HLA-DQDQB1*06:07,06:07
HLA-DRDRB1*13:02,14:46
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.28
Native American0
East Asian, North78.17
East Asian, South20.72
South Asian0.15
European, North0.14
European, South0.54
Disease Thoracic SMARCA4-deficient undifferentiated tumor (NCIt: C183115)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=713880; JCRB=JCRB0819

Markers:
AmelogeninX,Y
CSF1PO10
D5S81810,11
D7S8208,11
D13S3178,10
D16S53912
TH016
TPOX9,12
vWA14,18

Run an STR similarity search on this cell line
Publications

CLPUB00132
Nobuyasu Kishimoto, Taisuke Ohnoshi, Shunkichi Hiraki, Kenishi Miyake, Shiro Ozawa, Tetsuo Tamura, Takeyuki Numata, Shin Kawahara, Ryo Tamura, Hiroaki Miyamoto, Kenji Nishii, Ikuro Kimura;
Establishment and characterization of five cell lines from human small cell carcinoma of the lung.
Nihon Haigan Gakkai 24:644-644(1984)

DOI=10.4044/joma1947.104.9-10_905
Nobuyasu Kishimoto;
Studies on cell biology and chemotherapy of lung cancer using tissue culture techniques. Part 2. Biological characteristics of five newly established small cell lung cancer cell lines.
Okayama Igakkai Zasshi 104:905-913(1992)

PubMed=8286010
Katsuyuki Kiura, Shinobu Watarai, Takuo Shibayama, Taisuke Ohnoshi, Ikuro Kimura, Tatsuji Yasuda;
Inhibitory effects of cholera toxin on in vitro growth of human lung cancer cell lines.
Anticancer Drug Des. 8:417-428(1993)

PubMed=8263009; DOI=10.1007/BF01202192
Tatsuhiko Kashii, Yutaka Mizushima, Satoshi Monno, K. Nakagawa, M. Kobayashi;
Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method.
J. Cancer Res. Clin. Oncol. 120:143-148(1994)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9413215
Hiromishi Yamane, Katsuyuki Kiura, Masahiro Tabata, Akihiro Bessho, Tadashi Tsuchida, Kinya Motoda, Akio Hiraki, Hiroshi Ueoka, Mine Harada;
Small cell lung cancer can express CD34 antigen.
Anticancer Res. 17:3627-3632(1997)

PubMed=9673367
Takashi Fujishita, Yutaka Mizushima, Tatsuhiko Kashii, Masashi Kobayashi;
Coincidental alterations of p16INK4A/CDKN2 and other genes in human lung cancer cell lines.
Anticancer Res. 18:1537-1542(1998)

PubMed=10358721; DOI=10.18926/AMO/31626
Akio Matsushita, Masahiro Tabata, Hiroshi Ueoka, Katsuyuki Kiura, Takuo Shibayama, Keisuke Aoe, Hiroyuki Kohara, Mine Harada;
Establishment of a drug sensitivity panel using human lung cancer cell lines.
Acta Med. Okayama 53:67-75(1999)

PubMed=10536175; DOI=10.3892/ijo.15.5.927
Takeshi Fujita, Masaharu Kiyama, Yoshio Tomizawa, Takashi Kohno, Jun Yokota;
Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.
Int. J. Oncol. 15:927-934(1999)

PubMed=11005564; DOI=10.1038/sj.neo.7900094; PMCID=PMC1550293
Takashi Kohno, Takako Sato, Satoshi Takakura, Kimiko Takei, Kaoru Inoue, Michiho Nishioka, Jun Yokota;
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7; PMCID=PMC1850681
Sana Yokoi, Kohichiroh Yasui, Fumiko Saito-Ohara, Katsumi Koshikawa, Toshihiko Iizasa, Takehiko Fujisawa, Takeo Terasaki, Akira Horii, Takashi Takahashi, Setsuo Hirohashi, Johji Inazawa;
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
Am. J. Pathol. 161:207-216(2002)

PubMed=15016488; DOI=10.1016/S0140-6736(04)15693-6
Michael H. Jones, Carl Virtanen, Daisuke Honjoh, Tatsu Miyoshi, Yukitoshi Satoh, Sakae Okumura, Ken Nakagawa, Hitoshi Nomura, Yuichi Ishikawa;
Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles.
Lancet 363:775-781(2004)

PubMed=15185009; DOI=10.1007/s00262-004-0533-9; PMCID=PMC11034254
Haruko Yamaji, Toshihiko Iizasa, Eitetsu Koh, Makoto Suzuki, Mizuto Otsuji, Hao Chang, Shinichiro Motohashi, Sana Yokoi, Kenzo Hiroshima, Masatoshi Tagawa, Toshinori Nakayama, Takehiko Fujisawa;
Correlation between interleukin 6 production and tumor proliferation in non-small cell lung cancer.
Cancer Immunol. Immunother. 53:786-792(2004)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22399608
Tadashi Tsuchida, Hiromishi Yamane, Nobuaki Ochi, Takayuki Tabayashi, Akio Hiraki, Naoyuki Nogami, Nagio Takigawa, Katsuyuki Kiura, Mitsune Tanimoto;
Cytotoxicity of activated natural killer cells and expression of adhesion molecules in small-cell lung cancer.
Anticancer Res. 32:887-892(2012)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23066953; DOI=10.1111/cas.12045; PMCID=PMC7657141
Toshio Kubo, Nagio Takigawa, Masahiro Osawa, Daijiro Harada, Takashi Ninomiya, Nobuaki Ochi, Eiki Ichihara, Hiromishi Yamane, Mitsune Tanimoto, Katsuyuki Kiura;
Subpopulation of small-cell lung cancer cells expressing CD133 and CD87 show resistance to chemotherapy.
Cancer Sci. 104:78-84(2013)

PubMed=23381221; DOI=10.3892/or.2013.2266; PMCID=PMC3621652
Makoto Suzuki, Kenji Shiraishi, Ayami Eguchi, Koei Ikeda, Takeshi Mori, Kentaro Yoshimoto, Yasuomi Ohba, Tatsuya Yamada, Takaaki Ito, Yoshifumi Baba, Hideo Baba;
Aberrant methylation of LINE-1, SLIT2, MAL and IGFBP7 in non-small cell lung cancer.
Oncol. Rep. 29:1308-1314(2013)

PubMed=25120651; DOI=10.3892/ol.2014.2234; PMCID=PMC4114630
Makoto Suzuki, Koei Ikeda, Kenji Shiraishi, Ayami Eguchi, Takeshi Mori, Kentaro Yoshimoto, Hidekatsu Shibata, Takaaki Ito, Yoshifumi Baba, Hideo Baba;
Aberrant methylation and silencing of IRF8 expression in non-small cell lung cancer.
Oncol. Lett. 8:1025-1030(2014)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=38180245; DOI=10.1158/1078-0432.CCR-23-2360; PMCID=PMC11061608
Jin Ng, Ling Cai, Luc Girard, Owen W.J. Prall, Neeha Sulakshi Rajan, Christine Khoo, Ahida Batrouney, David J. Byrne, Danielle K. Boyd, Ariena J. Kersbergen, Michael Christie ...Show all 14 authors... , John D. Minna, Marian L. Burr, Kate D. Sutherland; Show fewer authors
Molecular and pathologic characterization of YAP1-expressing small cell lung cancer cell lines leads to reclassification as SMARCA4-deficient malignancies.
Clin. Cancer Res. 30:1846-1858(2024)

Cross-references
Cell line collections (Providers) JCRB; JCRB0819
Cell line databases/resources CLO; CLO_0037043
cancercelllines; CVCL_1679
Cell_Model_Passport; SIDM00368
CGH-DB; 9050-4
CGH-DB; 95-1
Cosmic-CLP; 713880
DepMap; ACH-000670
LINCS_LDP; LCL-1821
Biological sample resources BioSample; SAMN03472516
BioSample; SAMN10988207
Chemistry resources ChEMBL-Cells; CHEMBL3308493
ChEMBL-Targets; CHEMBL614896
GDSC; 713880
PharmacoDB; SBC5_1349_2019
PubChem_Cell_line; CVCL_1679
Encyclopedic resources Wikidata; Q54952179
Experimental variables resources EFO; EFO_0002855
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM17314
GEO; GSM827566
GEO; GSM887556
GEO; GSM888639
GEO; GSM986192
GEO; GSM1670406
Polymorphism and mutation databases Cosmic; 713880
Cosmic; 801614
Cosmic; 844823
Cosmic; 876155
Cosmic; 918017
Cosmic; 929153
Cosmic; 932946
Cosmic; 1212201
Cosmic; 1571747
Cosmic; 1995624
Cosmic; 2125287
Cosmic; 2668344
IARC_TP53; 2387
LiGeA; CCLE_781
Progenetix; CVCL_1679
Proteomic databases PRIDE; PXD011896
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number42