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Cellosaurus SAS (CVCL_1675)

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Cell line name SAS
Accession CVCL_1675
Resource Identification Initiative To cite this cell line use: SAS (RRID:CVCL_1675)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 33 hours (PubMed=24627082); ~30 hours (Note=Lot 07312007), ~21 hours (Note=Lot 08022016) (JCRB=JCRB0260).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu336Ter (c.1006G>T); Zygosity=Homozygous (Cosmic-CLP=909708; DepMap=ACH-002029).
HLA typing Source: PubMed=9178645
Class I
HLA-AA*24
HLA-BB*52:01
HLA-CC*12:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.4
Native American0
East Asian, North79.62
East Asian, South16.48
South Asian1.04
European, North0
European, South1.46
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_R859 (SAS-H1)CVCL_R860 (SAS-L1)CVCL_A8GP (SAS-R)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=909708; DepMap=ACH-002029; JCRB=JCRB0260; RCB=RCB1974; TKG=TKG 0470

Markers:
AmelogeninX
CSF1PO11
D3S135816,17
D5S8189
D7S82011,12
D8S117911,13
D13S31710,12
D16S53912,13
D18S5115
D21S1130
FGA24
Penta D10,13
Penta E5,20
TH016,7
TPOX11,12
vWA10,14 (Cosmic-CLP=909708)
10,14,17 (JCRB=JCRB0260)
14,17 (DepMap=ACH-002029; RCB=RCB1974; TKG=TKG 0470)

Run an STR similarity search on this cell line
Web pages Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/other-bladder-cervical/sas-xenograft-model/
Publications

DOI=10.11277/stomatology1952.38.20
Kikuo Takahashi, Harusachi Kanazawa, Yukihiro Akiyama, Shigeko Tazaki, Masaaki Takahara, Toshitaka Muto, Hideki Tanzawa, Ken-ichi Sato;
Establishment and characterization of a cell line (SAS) from poorly differentiated human squamous cell carcinoma of the tongue.
J. Jpn. Stomatol. Soc. 38:20-28(1989)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Naoko Seki, Tomoaki Hoshino, Megumi Kikuchi, Akihiro Hayashi, Kyogo Itoh;
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=9178645; DOI=10.1006/cimm.1997.1108
Masanobu Nakao, Michio Sata, Hideki Saitsu, Shigeru Yutani, Mayumi Kawamoto, Masamichi Kojiro, Kyogo Itoh;
CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular carcinoma.
Cell. Immunol. 177:176-181(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura, Mitsuyoshi Matsuo, Hiroshi Mizusawa ...Show all 18 authors... , Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

DOI=10.5843/jsot.13.Suppliment_301
Tadateru Aida, Tarou Irie, Tetsuhiko Tachikawa;
Establishment and charactalization of human oral squamous cell carcinoma cell line with highly lymph node metastatic potential.
J. Jpn. Soc. Oral Oncol. 13 Suppl. 1:301-306(2001)

PubMed=17325662; DOI=10.1038/sj.onc.1210330
K. Nakaya, Hidehisa D. Yamagata, Norimasa Arita, Koh-ichi Nakashiro, Masato Nose, Tetsuro Miki, Hiroyuki Hamakawa;
Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.
Oncogene 26:5300-5308(2007)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa, Jonathan Hinton, Ciara Fahey ...Show all 22 authors... , Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera, Rui Wang, Angela Tam ...Show all 22 authors... , Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24627082; DOI=10.3892/ijo.2014.2332
Takahiro Fujinaga, Wataru Kumamaru, Tsuyoshi Sugiura, Yosuke Kobayashi, Yukiko Ohyama, Tatsuya Ikari, Mitsuho Onimaru, Naonari Akimoto, Rumi Jogo, Yoshihide Mori;
Biological characterization and analysis of metastasis-related genes in cell lines derived from the primary lesion and lymph node metastasis of a squamous cell carcinoma arising in the mandibular gingiva.
Int. J. Oncol. 44:1614-1624(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer, Patricia Greninger, Ewald van Dyk ...Show all 39 authors... , Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari, Sarah Harper, David Adam Jackson ...Show all 25 authors... , Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=32990596; DOI=10.7554/eLife.57761; PMCID=PMC7591259
Annie Wai-Yeeng Chai, Pei-San Yee, Stacey Price, Shi-Mun Yee, Hui-Mei Lee, Vivian K.H. Tiong, Emanuel Goncalves, Fiona M. Behan, Jessica Bateson, James G.R. Gilbert, Aik-Choon Tan, Ultan McDermott, Mathew J. Garnett ...Show all 14 authors... , Sok-Ching Cheong; Show fewer authors
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway.
eLife 9:e57761.1-e57761.34(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker, Jennifer Koh, Howard Lightfoot ...Show all 32 authors... , Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB0260
RCB; RCB1974
TKG; TKG 0470
Cell line databases/resources CLO; CLO_0051568
cancercelllines; CVCL_1675
Cell_Model_Passport; SIDM00351
Cosmic-CLP; 909708
DepMap; ACH-002029
LINCS_LDP; LCL-1221
Anatomy/cell type resources BTO; BTO_0003981
Biological sample resources BioSample; SAMN03471668
BioSample; SAMN03472049
CRISP screens repositories BioGRID_ORCS_Cell_line; 1004
Chemistry resources ChEMBL-Cells; CHEMBL3308781
ChEMBL-Targets; CHEMBL1075569
GDSC; 909708
PharmacoDB; SAS_1345_2019
PubChem_Cell_line; CVCL_1675
Encyclopedic resources Wikidata; Q54952119
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10544-107H4
GEO; GSM827230
GEO; GSM850387
GEO; GSM950309
GEO; GSM950310
GEO; GSM950311
GEO; GSM950312
GEO; GSM1670402
Polymorphism and mutation databases Cosmic; 909708
Cosmic; 1042300
Cosmic; 1118787
Cosmic; 1120705
Cosmic; 1571803
Cosmic; 2546833
IARC_TP53; 23803
Progenetix; CVCL_1675
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number39