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Cellosaurus RPMI-8866 (CVCL_1668)

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Cell line name RPMI-8866
Synonyms RPMI 8866; RPMI8866; Roswell Park Memorial Institute 8866; R8866; 8866
Accession CVCL_1668
Resource Identification Initiative To cite this cell line use: RPMI-8866 (RRID:CVCL_1668)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
HLA typing Source: PubMed=6967232
Class I
HLA-AA*02,03
HLA-BB*07
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.14
East Asian, North0
East Asian, South0
South Asian3.24
European, North67.29
European, South29.33
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 51Y
Category Transformed cell line
STR profile Source(s): Cosmic-CLP=910544; ECACC=95041316; PubMed=17254797

Markers:
AmelogeninX
CSF1PO11
D3S135815,16
D5S81812
D7S82011,12
D8S117912,14
D13S31710,14
D16S53911
D18S5112,15
D21S1127,29
FGA22,23
TH019.3 (Cosmic-CLP=910544; ECACC=95041316)
10 (PubMed=17254797)
TPOX8,11
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=4169031; DOI=10.4049/jimmunol.99.5.839
Ira Finegold, John L. Fahey, Harriet Granger;
Synthesis of immunoglobulins by human cell lines in tissue culture.
J. Immunol. 99:839-848(1967)

DOI=10.1007/978-1-4757-1647-4_11
George Eugene Moore;
Cell lines from humans with hematopoietic malignancies.
(In book chapter) Human tumor cells in vitro; Fogh, Jorgen (eds.); pp.299-331; Springer; New York; USA (1975)

PubMed=6967232; DOI=10.1007/BF01538802
Paul Gladstone, Donald A. Pious;
Identification of a trans-acting function regulation HLA-DR expression in a DR-negative B cell variant.
Somatic Cell Genet. 6:285-298(1980)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Shahram Azari, Nahid Ahmadi, Mahmood Jeddi-Tehrani, Fazel Shokri;
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ECACC; 95041316
Cell line databases/resources CLO; CLO_0008875
CLO; CLO_0009858
CLDB; cl4186
Cell_Model_Passport; SIDM00482
Cosmic-CLP; 910544
DepMap; ACH-002302
LINCS_LDP; LCL-1113
Anatomy/cell type resources BTO; BTO_0004206
Chemistry resources ChEMBL-Cells; CHEMBL3308323
ChEMBL-Targets; CHEMBL2366341
GDSC; 910544
PharmacoDB; RPMI8866_1329_2019
PubChem_Cell_line; CVCL_1668
Encyclopedic resources Wikidata; Q54951275
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670391
Polymorphism and mutation databases Cosmic; 910544
IARC_TP53; 21292
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37