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Cellosaurus RERF-LC-MS (CVCL_1655)

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Cell line name RERF-LC-MS
Synonyms RERF-LCMS; RERFLCMS; LC-MS; LCMS; Radiation Effects Research Foundation-Lung Cancer-MS
Accession CVCL_1655
Resource Identification Initiative To cite this cell line use: RERF-LC-MS (RRID:CVCL_1655)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 39.9 hours (PubMed=8286010); 42.7 hours (Note=Lot 012194), 30-38 hours (Note=Lot 08102009) (JCRB=JCRB0081).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Misspelling: REAF-LC-MS; Cosmic=1571722.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
HLA typing Source: PubMed=9023415
Class I
HLA-AA*11:01
HLA-BB*54:01
HLA-CC*01:02

Source: PubMed=26589293
Class I
HLA-AA*11:01,11:01
HLA-BB*54:01,54:01
HLA-CC*01:02,01:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.74
Native American0.17
East Asian, North85.02
East Asian, South8.67
South Asian0
European, North0
European, South4.39
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=910931; JCRB=JCRB0081; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO12,13
D3S135816
D5S81810,13
D7S82011,12
D8S117911,14
D13S31710
D16S53912
D18S5116
D21S1130
FGA24
Penta D10
Penta E14,15
TH017
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=8286010
Katsuyuki Kiura, Shinobu Watarai, Takuo Shibayama, Taisuke Ohnoshi, Ikuro Kimura, Tatsuji Yasuda;
Inhibitory effects of cholera toxin on in vitro growth of human lung cancer cell lines.
Anticancer Drug Des. 8:417-428(1993)

PubMed=8263009; DOI=10.1007/BF01202192
Tatsuhiko Kashii, Yutaka Mizushima, Satoshi Monno, K. Nakagawa, M. Kobayashi;
Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method.
J. Cancer Res. Clin. Oncol. 120:143-148(1994)

PubMed=7834619
Osuke Washimi, Masaaki Nagatake, Hirotaka Osada, Ryuzo Ueda, Takashi Koshikawa, Tsuneo Seki, Toshitada Takahashi, Takashi Takahashi;
In vivo occurrence of p16 (MTS1) and p15 (MTS2) alterations preferentially in non-small cell lung cancers.
Cancer Res. 55:514-517(1995)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Naoko Seki, Tomoaki Hoshino, Megumi Kikuchi, Akihiro Hayashi, Kyogo Itoh;
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=10358721; DOI=10.18926/AMO/31626
Akio Matsushita, Masahiro Tabata, Hiroshi Ueoka, Katsuyuki Kiura, Takuo Shibayama, Keisuke Aoe, Hiroyuki Kohara, Mine Harada;
Establishment of a drug sensitivity panel using human lung cancer cell lines.
Acta Med. Okayama 53:67-75(1999)

PubMed=10536175; DOI=10.3892/ijo.15.5.927
Takeshi Fujita, Masaharu Kiyama, Yoshio Tomizawa, Takashi Kohno, Jun Yokota;
Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.
Int. J. Oncol. 15:927-934(1999)

PubMed=11005564; DOI=10.1038/sj.neo.7900094; PMCID=PMC1550293
Takashi Kohno, Takako Sato, Satoshi Takakura, Kimiko Takei, Kaoru Inoue, Michiho Nishioka, Jun Yokota;
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=12569360; DOI=10.1038/sj.onc.1206106
Toshiki Funakoshi, Isao Tachibana, Yoshihiko Hoshida, Hiromi Kimura, Yoshito Takeda, Takashi Kijima, Kazumi Nishino, Hiroyuki Goto, Tsutomu Yoneda, Toru Kumagai, Tadashi Osaki ...Show all 14 authors... , Seiji Hayashi, Katsuyuki Aozasa, Ichiro Kawase; Show fewer authors
Expression of tetraspanins in human lung cancer cells: frequent downregulation of CD9 and its contribution to cell motility in small cell lung cancer.
Oncogene 22:674-687(2003)

PubMed=14581340
Sana Yokoi, Kohichiroh Yasui, Toshihiko Iizasa, Issei Imoto, Takehiko Fujisawa, Johji Inazawa;
TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers.
Clin. Cancer Res. 9:4705-4713(2003)

PubMed=15746151; DOI=10.1093/hmg/ddi092
Hiroto Izumi, Jun Inoue, Sana Yokoi, Hiroshi Hosoda, Tatsuhiro Shibata, Makoto Sunamori, Setsuo Hirohashi, Johji Inazawa, Issei Imoto;
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.
Hum. Mol. Genet. 14:997-1007(2005)

PubMed=15999539
Tadashi Matsumura, Nagio Takigawa, Katsuyuki Kiura, Takuo Shibayama, Masakazu Chikamori, Masahiro Tabata, Hiroshi Ueoka, Mitsune Tanimoto;
Determinants of cisplatin and irinotecan activities in human lung adenocarcinoma cells: evidence of cisplatin accumulation and topoisomerase I activity.
In Vivo 19:717-721(2005)

PubMed=16105816; DOI=10.1158/0008-5472.CAN-05-0331
Yoshiaki Nagai, Hitoshi Miyazawa, Huqun No_last_name, Tomoaki Tanaka, Kiyoshi Udagawa, Motoyasu Kato, Shunichiro Fukuyama, Akemi Yokote, Kunihiko Kobayashi, Minoru Kanazawa, Koichi Hagiwara;
Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.
Cancer Res. 65:7276-7282(2005)

PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846
Raquel Blanco, Reika Iwakawa, Mo-Ying Tang, Takashi Kohno, Barbara Angulo, Ruben Pio, Luis M. Montuenga, John D. Minna, Jun Yokota, Montse Sanchez-Cespedes;
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680
Reika Iwakawa, Takashi Kohno, Masatoshi Enari, Tohru Kiyono, Jun Yokota;
Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.
Cancer Sci. 101:1891-1896(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB0081
Cell line databases/resources CLO; CLO_0037039
cancercelllines; CVCL_1655
Cell_Model_Passport; SIDM00355
CGH-DB; 206-1
CGH-DB; 9166-4
Cosmic-CLP; 910931
DepMap; ACH-000062
LINCS_LDP; LCL-1665
Biological sample resources BioSample; SAMN03471374
BioSample; SAMN10987805
Chemistry resources ChEMBL-Cells; CHEMBL3308463
ChEMBL-Targets; CHEMBL1075563
GDSC; 910931
PharmacoDB; RERFLCMS_1306_2019
PubChem_Cell_line; CVCL_1655
Encyclopedic resources Wikidata; Q54949773
Experimental variables resources EFO; EFO_0002852
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM274673
GEO; GSM827590
GEO; GSM887536
GEO; GSM888618
GEO; GSM1670373
Polymorphism and mutation databases Cosmic; 713865
Cosmic; 801585
Cosmic; 844844
Cosmic; 876141
Cosmic; 889095
Cosmic; 910931
Cosmic; 917984
Cosmic; 929154
Cosmic; 932931
Cosmic; 934468
Cosmic; 946064
Cosmic; 1066167
Cosmic; 1219067
Cosmic; 1239898
Cosmic; 1571722
Cosmic; 1995619
Cosmic; 2125190
Cosmic; 2668309
IARC_TP53; 11878
IARC_TP53; 28452
LiGeA; CCLE_605
Progenetix; CVCL_1655
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number44