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Cellosaurus PFSK-1 (CVCL_1642)

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Cell line name PFSK-1
Synonyms PFSk-1; PFSK1; PFSK
Accession CVCL_1642
Resource Identification Initiative To cite this cell line use: PFSK-1 (RRID:CVCL_1642)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ENCODE project common cell types; tier 3.
Population: Caucasian.
Doubling time: ~30 hours (ATCC=CRL-2060).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Brain, right frontal lobe; UBERON=UBERON_0002810.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys275Gly (c.823T>G); ClinVar=VCV001414106; Zygosity=Homozygous (Cosmic-CLP=683667).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.31
Native American0
East Asian, North2.03
East Asian, South0
South Asian0.77
European, North66.34
European, South30.55
Disease Primitive neuroectodermal tumor (NCIt: C3716)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 1Y10M
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2060; Cosmic-CLP=683667; DepMap=ACH-001711

Markers:
AmelogeninX,Y
CSF1PO11
D2S133817,20
D3S135815,16,18
D5S81811,12
D7S82010
D8S117913,14
D13S31712,14
D16S53913
D18S5112
D19S43313.2,14
D21S1128,32.2
FGA20,22
Penta D9,12
Penta E12,17
TH019,9.3
TPOX8,9
vWA17,18

Run an STR similarity search on this cell line
Web pages Info; ENCODE; -; http://genome.ucsc.edu/ENCODE/protocols/cell/human/PFSK-1_protocol.pdf
Publications

PubMed=1316433; DOI=10.1097/00005072-199205000-00005
Daniel Webster Fults, Carolyn A. Pedone, Helvise G. Morse, John W. Rose, Ronald Davies Graham McKay;
Establishment and characterization of a human primitive neuroectodermal tumor cell line from the cerebral hemisphere.
J. Neuropathol. Exp. Neurol. 51:272-280(1992)

DOI=10.1016/B978-0-12-333530-2.50005-8
Monica Nister, Bengt Westermark;
Human glioma cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.17-42; Academic Press; New York; USA (1994)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=23325432; DOI=10.1101/gr.147942.112; PMCID=PMC3589544
Katherine E. Varley, Jason Gertz, Kevin M. Bowling, Stephanie L. Parker, Timothy E. Reddy, Florencia Pauli-Behn, Marie K. Cross, Brian A. Williams, John A. Stamatoyannopoulos, Gregory E. Crawford, Devin Michael Absher ...Show all 13 authors... , Barbara Jane Wold, Richard M. Myers; Show fewer authors
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-2060
IZSLER; BS TCL 202
Cell line databases/resources CLO; CLO_0008425
cancercelllines; CVCL_1642
Cell_Model_Passport; SIDM01132
Cosmic-CLP; 683667
DepMap; ACH-001711
LINCS_LDP; LCL-1407
Biological sample resources BioSample; SAMN03471425
ENCODE; ENCBS054ENC
Chemistry resources ChEMBL-Cells; CHEMBL3308802
ChEMBL-Targets; CHEMBL1075560
GDSC; 683667
PharmacoDB; PFSK1_1264_2019
PubChem_Cell_line; CVCL_1642
Encyclopedic resources Wikidata; Q54947302
Experimental variables resources EFO; EFO_0005234
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM923430
GEO; GSM1670349
Polymorphism and mutation databases Cosmic; 683667
Cosmic; 923655
Cosmic; 973260
Cosmic; 1728490
Cosmic; 1995615
IARC_TP53; 21279
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37