Cellosaurus logo
expasy logo

Cellosaurus Panc 02.13 (CVCL_1634)

[Text version]
Cell line name Panc 02.13
Synonyms Panc 2.13; Panc-02.13; PANC-02-13; Panc2.13; PANC0213; PL1; PL-1
Accession CVCL_1634
Resource Identification Initiative To cite this cell line use: Panc 02.13 (RRID:CVCL_1634)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
From: Johns Hopkins University School of Medicine; Baltimore; USA.
Population: Caucasian.
Doubling time: 33.9 hours (PubMed=9612602).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000045115; Zygosity=Heterozygous (DepMap=ACH-000031).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Homozygous (DepMap=ACH-000031).
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.03
Native American0.98
East Asian, North0.28
East Asian, South0
South Asian0.04
European, North63.98
European, South32.69
Disease Pancreatic adenocarcinoma (NCIt: C8294)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2554; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D2S133817
D3S135816,18
D5S81812
D7S8207,11
D8S117912,13
D13S3178,11
D16S5399,12
D18S5111
D19S43313.2,14
D21S1129
FGA21,23
Penta D12
Penta E8,13
TH016,9.3
TPOX8
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=9612602
Elizabeth Marion Jaffee, Mieke Schutte, Jeanette Gossett, Laura A. Morsberger, Adam J. Adler, Matthew Thomas, Tim F. Greten, Ralph H. Hruban, Charles J. Yeo, Constance A. Griffin;
Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials.
Cancer J. Sci. Am. 4:194-203(1998)

PubMed=14695172
Christine A. Iacobuzio-Donahue, Raheela Ashfaq, Anirban Maitra, Nazmi Volkan Adsay, Grace L.-C. Shen-Ong, Karin Berg, Michael Anthony Hollingsworth, John Lemuel Cameron, Charles J. Yeo, Scott E. Kern, Michael Gilbert Goggins, Ralph H. Hruban;
Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies.
Cancer Res. 63:8614-8622(2003)

PubMed=16912165; DOI=10.1158/0008-5472.CAN-06-0721
Eric S. Calhoun, Tomas Hucl, Eike Gallmeier, Kristen M. West, Dan E. Arking, Anirban Maitra, Christine A. Iacobuzio-Donahue, Aravinda Chakravarti, Ralph H. Hruban, Scott E. Kern;
Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays.
Cancer Res. 66:7920-7928(2006)

PubMed=18000365; DOI=10.1159/000108295
Constance A. Griffin, Laura A. Morsberger, Anita L. Hawkins, Mary H. Haddadin, Ankita S. Patel, Thomas Ried, Evelin Schrock, Elizabeth J. Perlman, Elizabeth Marion Jaffee;
Molecular cytogenetic characterization of pancreas cancer cell lines reveals high complexity chromosomal alterations.
Cytogenet. Genome Res. 118:148-156(2007)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25167228; DOI=10.1038/bjc.2014.475; PMCID=PMC4453732
Habib Hamidi, Ming Lu, Kevin Chau, Lee Anderson, Marlena Schoenberg Fejzo, Charles Ginther, Ronald Linnartz, Angela Zubel, Dennis Joseph Slamon, Richard Samuel Finn;
KRAS mutational subtype and copy number predict in vitro response of human pancreatic cancer cell lines to MEK inhibition.
Br. J. Cancer 111:1788-1801(2014)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-2554
Cell line databases/resources CLO; CLO_0008375
cancercelllines; CVCL_1634
Cell_Model_Passport; SIDM01325
DepMap; ACH-000031
Biological sample resources BioSample; SAMN03472905
BioSample; SAMN10987902
Chemistry resources PharmacoDB; Panc02_13_1240_2019
Encyclopedic resources Wikidata; Q54937515
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887495
GEO; GSM888577
GEO; GSM1024406
Polymorphism and mutation databases IARC_TP53; 28234
LiGeA; CCLE_679
Progenetix; CVCL_1634
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number28