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Cellosaurus P30/OHK (CVCL_1631)

[Text version]
Cell line name P30/OHK
Synonyms P30-OHK; P30_OHK; P30 OHK; P30OHK; P30/Ohkubo; P30/OHKUBO; P30-OHKUBO; P30/0HK
Accession CVCL_1631
Resource Identification Initiative To cite this cell line use: P30/OHK (RRID:CVCL_1631)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: ~30 hours (PubMed=6983990); ~30 hours (DSMZ=ACC-727).
Microsatellite instability: Instable (MSI-high) (PubMed=10739008; PubMed=31068700; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:6997; MEF2D + HGNC; HGNC:17011; HNRNPUL1; Name(s)=MEF2D-HNRNPUL1 (PubMed=35354797).
  • Mutation; HGNC; HGNC:7978; NR3C1; Simple; p.Cys643Arg (c.1927T>C) (p.Cys644Arg, c.1930T>C); Zygosity=Heterozygous (PubMed=35124168).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North75.09
East Asian, South24.91
South Asian0
European, North0
European, South0
Disease Childhood B acute lymphoblastic leukemia (NCIt: C9140)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 11Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=909252; DSMZ=ACC-727; JCRB=JCRB0094; RCB=RCB1938; TKG=TKG 0463

Markers:
AmelogeninX
CSF1PO9,11
D2S133819
D3S135815
D5S81811,12
D7S82010,11
D8S117910,12
D13S3179,10 (DSMZ=ACC-727)
10 (Cosmic-CLP=909252; JCRB=JCRB0094; RCB=RCB1938; TKG=TKG 0463)
D16S5399 (Cosmic-CLP=909252; JCRB=JCRB0094; RCB=RCB1938; TKG=TKG 0463)
9,10 (DSMZ=ACC-727)
D18S5112,13,14,16,17
D19S43312,13
D21S1130.2,32.2
FGA18
Penta D9,11
Penta E12,18
TH018,9 (DSMZ=ACC-727)
9 (Cosmic-CLP=909252; JCRB=JCRB0094; RCB=RCB1938; TKG=TKG 0463)
TPOX10,11 (Cosmic-CLP=909252; JCRB=JCRB0094; RCB=RCB1938; TKG=TKG 0463)
11 (DSMZ=ACC-727)
vWA14,19 (DSMZ=ACC-727)
14,21 (Cosmic-CLP=909252; JCRB=JCRB0094; RCB=RCB1938; TKG=TKG 0463)

Run an STR similarity search on this cell line
Publications

PubMed=6983990
Masao Hirose, Keisuke Minato, Kensei Tobinai, Mutuo Ohira, Tohru Ise, Shaw Watanabe, Masanori Shimoyama, Masafumi Taniwaki, Tatsuo Abe;
A novel pre-T cell line derived from acute lymphoblastic leukemia.
Gann 73:600-605(1982)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 Carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588
Noriko Hosoya, Akira Hangaishi, Seishi Ogawa, Kiyoshi Miyagawa, Kinuko Mitani, Yoshio Yazaki, Hisamaru Hirai;
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2
Yoshinobu Matsuo, Hans Gunther Drexler;
Establishment and characterization of human B cell precursor-leukemia cell lines.
Leuk. Res. 22:567-579(1998)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29786757; DOI=10.1007/s12185-018-2474-7
Chihiro Tomoyasu, Toshihiko Imamura, Toshihiro Tomii, Mio Yano, Daisuke Asai, Hiroaki Goto, Akira Shimada, Masashi Sanada, Shotaro Iwamoto, Junko Takita, Masayoshi Minegishi ...Show all 14 authors... , Takeshi Inukai, Kanji Sugita, Hajime Hosoi; Show fewer authors
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Int. J. Hematol. 108:312-318(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Minori Tamai, Shin Kasai, Koshi Akahane, Thao Nguyen Thu, Keiko Kagami, Chiaki Komatsu, Masako Abe, Atsushi Watanabe, Kumiko Goi, Kunio Miyake, Toshiya Inaba ...Show all 17 authors... , Junko Takita, Hiroaki Goto, Masayoshi Minegishi, Shotaro Iwamoto, Kanji Sugita, Takeshi Inukai; Show fewer authors
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900
Isabelle Rose Leo, Luay Aswad, Matthias Stahl, Elena Kunold, Frederik Post, Tom Erkers, Nona Struyf, Georgios Mermelekas, Rubin Narayan Joshi, Eva Gracia-Villacampa, Paivi Ostling ...Show all 17 authors... , Olli-Pekka Kallioniemi, Katja Pokrovskaja Tamm, Ioannis Siavelis, Janne Lehtio, Mattias Vesterlund, Rozbeh Jafari; Show fewer authors
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Nat. Commun. 13:1691.1-1691.19(2022)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-727
JCRB; JCRB0094
RCB; RCB1938
TKG; TKG 0463
Cell line databases/resources CLO; CLO_0051011
cancercelllines; CVCL_1631
Cell_Model_Passport; SIDM00364
Cosmic-CLP; 909252
DepMap; ACH-002059
DSMZCellDive; ACC-727
LINCS_LDP; LCL-1038
Biological sample resources BioSample; SAMN01821712
BioSample; SAMN03471069
Chemistry resources ChEMBL-Cells; CHEMBL3308275
ChEMBL-Targets; CHEMBL2366165
GDSC; 909252
PharmacoDB; P30OHK_1231_2019
PubChem_Cell_line; CVCL_1631
Encyclopedic resources Wikidata; Q54937245
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10430-106D7
GEO; GSM827254
GEO; GSM1670327
GEO; GSM5137736
GEO; GSM5137764
Polymorphism and mutation databases Cosmic; 909252
Cosmic; 919141
Cosmic; 998703
Cosmic; 1037718
IARC_TP53; 21273
Progenetix; CVCL_1631
Proteomic databases PRIDE; PXD023662
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number41