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Cellosaurus OMC-1 [Human cervical carcinoma] (CVCL_1623)

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Cell line name OMC-1 [Human cervical carcinoma]
Synonyms OMC1; Osaka Medical College-1
Accession CVCL_1623
Resource Identification Initiative To cite this cell line use: OMC-1 [Human cervical carcinoma] (RRID:CVCL_1623)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 43 hours (Note=At 15th passage) (PubMed=2486664).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North76.41
East Asian, South22.8
South Asian0
European, North0.62
European, South0.16
Disease Cervical squamous cell carcinoma, not otherwise specified (NCIt: C180839)
Squamous cell carcinoma of the cervix uteri (ORDO: Orphanet_213767)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=949154; RCB=RCB0753

Markers:
AmelogeninX
CSF1PO10,13
D5S81810,11
D7S82011,12
D13S3178,12
D16S53911,12
TH016
TPOX11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=3746026
Masatsugu Ueda, Takayoshi Maeda, Takashi Yamada, Yoshitaka Miyawaki, Yoshinori Otsuki, Yoshiaki Okamoto, Shinsuke Okamura, Takashi Sano, Minoru Ueki, Osamu Sugimoto;
Establishment and characterization of TA-4 producing cell line (OMC-1) originating from a human squamous cell carcinoma of the uterine cervix.
Nihon Sanka Fujinka Gakkai Zasshi 38:1071-1078(1986)

PubMed=2486664
Masatsugu Ueda, Minoru Ueki, Takashi Yamada, Yoshiaki Okamoto, Takayoshi Maeda, Osamu Sugimoto, Yoshinori Otsuki;
Scatchard analysis of EGF receptor and effects of EGF on growth and TA-4 production of newly established uterine cervical cancer cell line (OMC-1).
Hum. Cell 2:401-410(1989)

PubMed=2531191
Masatsugu Ueda, Osamu Misaki, Takashi Yamada, Yoshiaki Okamoto, Masaki Goto, Takayoshi Maeda, Shinsuke Okamura, Minoru Ueki, Osamu Sugimoto;
In vitro studies of 5-FU sensitivity on uterine cervical cancer cell lines -- comparison between squamous cell carcinoma and adenocarcinoma.
Nihon Sanka Fujinka Gakkai Zasshi 41:1423-1430(1989)

DOI=10.1267/ahc.26.515
Kazuo Tsuchida, Yoshiaki Okamoto, Takashi Yamada, Masatsugu Ueda, Junko Iijima, Yoshio Shiina, Hiroshi Hirano, Chiaki Rokukawa, Takeshi Kasama, Takao Taki, Shizuo Handa, Minoru Ueki, Kenji Adachi; Show fewer authors ...Show all 13 authors...
Discrimination of metastatic cells from mesothelial cells in effusion cytology by monoclonal antibody AD117m directed against lactotetraosylceramide.
Acta Histochem. Cytochem. 26:515-530(1993)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa, Jonathan Hinton, Ciara Fahey ...Show all 22 authors... , Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer, Patricia Greninger, Ewald van Dyk ...Show all 39 authors... , Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker, Jennifer Koh, Howard Lightfoot ...Show all 32 authors... , Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) RCB; RCB0753
Cell line databases/resources CLO; CLO_0050939
cancercelllines; CVCL_1623
Cell_Model_Passport; SIDM00240
Cosmic-CLP; 949154
DepMap; ACH-002180
LINCS_LDP; LCL-1546
Biological sample resources BioSample; SAMN03472225
Chemistry resources ChEMBL-Cells; CHEMBL3308213
ChEMBL-Targets; CHEMBL2366339
GDSC; 949154
PharmacoDB; OMC1_1199_2019
PubChem_Cell_line; CVCL_1623
Encyclopedic resources Wikidata; Q54932030
Gene expression databases ArrayExpress; E-MTAB-783
GEO; GSM1670305
Polymorphism and mutation databases Cosmic; 949154
Cosmic; 1152541
Cosmic; 1995602
IARC_TP53; 27570
Proteomic databases PRIDE; PXD030304
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number38