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Cellosaurus OE19 (CVCL_1622)

[Text version]
Cell line name OE19
Synonyms OE-19; JROECL 19; JROECL19; OEC19
Accession CVCL_1622
Resource Identification Initiative To cite this cell line use: OE19 (RRID:CVCL_1622)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Part of: TCGA-110-CL cell line panel.
Characteristics: Contains a 100 fold amplification of ERBB2 (PubMed=15511476).
Doubling time: ~50-60 hours (DSMZ=ACC-700).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Esophagus; UBERON=UBERON_0001043.
Sequence variations
  • Mutation; HGNC; HGNC:667; RHOA; Simple; p.Tyr42Ser (c.125A>C); Zygosity=Heterozygous (PubMed=34466148; DepMap=ACH-000679).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asn310Lysfs*27 (c.929dup) (c.929_930ins1); Zygosity=Heterozygous (Cosmic-CLP=910079; DepMap=ACH-000679).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,02:01
HLA-BB*07:17,51:01
HLA-CC*16:01,16:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African15.01
Native American0.16
East Asian, North1.83
East Asian, South0
South Asian11.79
European, North8.22
European, South62.99
Disease Esophageal adenocarcinoma (NCIt: C4025)
Adenocarcinoma of the esophagus (ORDO: Orphanet_99976)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=910079; DSMZ=ACC-700; ECACC=96071721; PubMed=20075370; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11,13
D2S133818,19
D3S135815,18
D5S81811,14
D7S8208
D8S117913,15
D13S3179,11
D16S53912,13
D18S5112 (PubMed=25877200)
12,13 (DSMZ=ACC-700; PubMed=20075370)
D19S43313
D21S1130
FGA23,26
Penta D9
Penta E5,8
TH018,9
TPOX8
vWA16,17 (Cosmic-CLP=910079; ECACC=96071721)
16,17,18 (DSMZ=ACC-700; PubMed=20075370; PubMed=25877200)

Run an STR similarity search on this cell line
Web pages Info; ECACC; -; https://www.culturecollections.org.uk/products/cell-cultures/ecacc-cell-line-profiles/oe19/
Info; HPA; -; https://www.proteinatlas.org/learn/cellines
Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=9010035; DOI=10.1038/bjc.1997.42; PMCID=PMC2063267
John C. Rockett, K. Larkin, S. Jane Darnton, Alan G. Morris, Hugoe R. Matthews;
Five newly established oesophageal carcinoma cell lines: phenotypic and immunological characterization.
Br. J. Cancer 75:258-263(1997)

PubMed=15511476; DOI=10.1016/j.athoracsur.2004.05.037
Peter S. Dahlberg, Blake A. Jacobson, Ganesh Dahal, James M. Fink, Robert A. Kratzke, Michael Anthony Maddaus, Lance Joseph Ferrin;
ERBB2 amplifications in esophageal adenocarcinoma.
Ann. Thorac. Surg. 78:1790-1800(2004)

PubMed=16364037; DOI=10.1111/j.1442-2050.2006.00530.x
M. Su, Suet-Feung Chin, X.-Y. Li, Paul A.W. Edwards, Carlos Caldas, Rebecca Clare Fitzgerald;
Comparative genomic hybridization of esophageal adenocarcinoma and squamous cell carcinoma cell lines.
Dis. Esophagus 19:10-14(2006)

PubMed=20075370; DOI=10.1093/jnci/djp499; PMCID=PMC2902814
Jurjen J. Boonstra, Ronald van Marion, David G. Beer, Lin Lin, Patricia Chaves, Catarina Ribeiro, A. Dias Pereira, Lucia Roque, S. Jane Darnton, Nasser Khaled Altorki, David S. Schrump ...Show all 19 authors... , David S. Klimstra, Laura H. Tang, James Richard Eshleman, Hector Alvarez, Yutaka Shimada, Herman van Dekken, Hugo W. Tilanus, Winand N.M. Dinjens; Show fewer authors
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
J. Natl. Cancer Inst. 102:271-274(2010)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24083764; DOI=10.7314/APJCP.2013.14.8.4891
Jian-Cheng Li, Di Liu, Yan Yang, Xiao-Ying Wang, Ding-Long Pan, Zi-Dan Qiu, Ying Su, Jian-Ji Pan;
Growth, clonability, and radiation resistance of esophageal carcinoma-derived stem-like cells.
Asian Pac. J. Cancer Prev. 14:4891-4896(2013)

PubMed=25070024; DOI=10.1007/s00423-014-1235-1
Astrid Drenckhan, Tobias Grob, Anna Dupree, Thorsten Dohrmann, Oliver Mann, Jakob Robert Izbicki, Stephanie J. Gros;
Esophageal carcinoma cell line with high EGFR polysomy is responsive to gefitinib.
Langenbecks Arch. Surg. 399:879-888(2014)

PubMed=23795680; DOI=10.1111/dote.12095
Jurjen J. Boonstra, Hugo W. Tilanus, Winand N.M. Dinjens;
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Dis. Esophagus 28:90-96(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26512696; DOI=10.3390/cancers7040881; PMCID=PMC4695881
Carol O'Callaghan, Liam J. Fanning, Orla P. Barry;
Hypermethylation of MAPK13 promoter in oesophageal squamous cell carcinoma is associated with loss of p38delta MAPK expression.
Cancers (Basel) 7:2124-2133(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785
Katharine Yu, Bin Chen, Dvir Aran, Joe Charalel, Christina Yau, Douglas M. Wolf, Laura J. van 't Veer, Atul Janardhan Butte, Ted Goldstein, Marina Sirota;
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574.1-3574.11(2019)

PubMed=34466148; DOI=10.3892/ol.2021.12996; PMCID=PMC8387854
Naoki Ikari, Akiko Serizawa, Etsuko Tanji, Masakazu Yamamoto, Toru Furukawa;
Analysis of RHOA mutations and their significance in the proliferation and transcriptome of digestive tract cancer cells.
Oncol. Lett. 22:735.1-735.7(2021)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-700
ECACC; 96071721
Cell line databases/resources CLO; CLO_0008238
CLDB; cl3761
cancercelllines; CVCL_1622
Cell_Model_Passport; SIDM00479
Cosmic-CLP; 910079
DepMap; ACH-000679
DSMZCellDive; ACC-700
IGRhCellID; OE19
LINCS_LDP; LCL-1796
Biological sample resources BioSample; SAMN03471032
BioSample; SAMN10988362
Chemistry resources ChEMBL-Cells; CHEMBL3308462
ChEMBL-Targets; CHEMBL1075555
GDSC; 910079
PharmacoDB; OE19_1194_2019
PubChem_Cell_line; CVCL_1622
Encyclopedic resources Wikidata; Q54931862
Experimental variables resources EFO; EFO_0002308
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM827301
GEO; GSM887475
GEO; GSM888555
GEO; GSM1264050
GEO; GSM1264051
GEO; GSM1264052
GEO; GSM1264053
GEO; GSM1264054
GEO; GSM1264092
GEO; GSM1264093
GEO; GSM1264094
GEO; GSM1264095
GEO; GSM1264096
GEO; GSM1670302
GEO; GSM7701391
GEO; GSM7701392
Polymorphism and mutation databases Cosmic; 871232
Cosmic; 910079
Cosmic; 978854
Cosmic; 997860
Cosmic; 1175878
Cosmic; 1599342
Cosmic; 1618819
Cosmic; 1995600
IARC_TP53; 21600
LiGeA; CCLE_923
Progenetix; CVCL_1622
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number43