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Cellosaurus NOS-1 [Human osteosarcoma] (CVCL_1610)

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Cell line name NOS-1 [Human osteosarcoma]
Synonyms NOS1
Accession CVCL_1610
Resource Identification Initiative To cite this cell line use: NOS-1 [Human osteosarcoma] (RRID:CVCL_1610)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Characteristics: Established from a xenograft established in a nude mice.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Bone; left proximal tibia.
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.97
East Asian, North79.98
East Asian, South18.61
South Asian0.44
European, North0
European, South0
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_T745 (NOS-1.C8 )
Sex of cell Male
Age at sampling 16Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; RCB

D7S8208,12,13 (RCB)
8,13 (Cosmic-CLP)

Run an STR similarity search on this cell line

PubMed=1449054; DOI=10.1111/j.1440-1827.1992.tb03110.x
Hotta T., Motoyama T., Watanabe H.
Three human osteosarcoma cell lines exhibiting different phenotypic expressions.
Acta Pathol. Jpn. 42:595-603(1992)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cell line collections RCB; RCB1032
Cell line databases/resources CLO; CLO_0050812
Cell_Model_Passport; SIDM00242
Cosmic-CLP; 925345
DepMap; ACH-002067
Biological sample resources BioSample; SAMN03472210
Chemistry resources ChEMBL-Cells; CHEMBL3308836
ChEMBL-Targets; CHEMBL2366141
GDSC; 925345
PharmacoDB; NOS1_1166_2019
Encyclopedic resources Wikidata; Q54930911
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670284
Polymorphism and mutation databases Cosmic; 925345
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update22-Sep-2022
Version number28