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Cellosaurus NOS-1 [Human osteosarcoma] (CVCL_1610)

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Cell line name NOS-1 [Human osteosarcoma]
Synonyms NOS1
Accession CVCL_1610
Resource Identification Initiative To cite this cell line use: NOS-1 [Human osteosarcoma] (RRID:CVCL_1610)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Characteristics: Established from a xenograft established in a nude mice.
Doubling time: 49.6 hours (PubMed=1449054).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Bone, left proximal tibia; UBERON=UBERON_0008772.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.97
East Asian, North79.98
East Asian, South18.61
South Asian0.44
European, North0
European, South0
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_T745 (NOS-1.C8)
Sex of cell Male
Age at sampling 16Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=925345; RCB=RCB1032

Markers:
AmelogeninX
CSF1PO9,13
D5S81810,12
D7S8208,12,13 (RCB=RCB1032)
8,13 (Cosmic-CLP=925345)
D13S3179,12
D16S53910,12,13
TH016
TPOX11
vWA14,16

Run an STR similarity search on this cell line
Publications

PubMed=1449054; DOI=10.1111/j.1440-1827.1992.tb03110.x
Tetsuo Hotta, Teiichi Motoyama, Hidenobu Watanabe;
Three human osteosarcoma cell lines exhibiting different phenotypic expressions.
Acta Pathol. Jpn. 42:595-603(1992)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) RCB; RCB1032
Cell line databases/resources CLO; CLO_0050812
cancercelllines; CVCL_1610
Cell_Model_Passport; SIDM00242
Cosmic-CLP; 925345
DepMap; ACH-002067
LINCS_LDP; LCL-1432
Biological sample resources BioSample; SAMN03472210
Chemistry resources ChEMBL-Cells; CHEMBL3308836
ChEMBL-Targets; CHEMBL2366141
GDSC; 925345
PharmacoDB; NOS1_1166_2019
PubChem_Cell_line; CVCL_1610
Encyclopedic resources Wikidata; Q54930911
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670284
Polymorphism and mutation databases Cosmic; 925345
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number34