Cellosaurus logo
expasy logo

Cellosaurus NKM-1 (CVCL_1607)

[Text version]
Cell line name NKM-1
Synonyms NKM1
Accession CVCL_1607
Resource Identification Initiative To cite this cell line use: NKM-1 (RRID:CVCL_1607)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 36-48 hours (PubMed=1701353).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North76.96
East Asian, South21.17
South Asian0.96
European, North0.9
European, South0.01
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=908448; JCRB=IFO50476

Markers:
AmelogeninX
CSF1PO10
D5S81810,12
D7S82010,11
D13S31711,13
D16S5399,12
TH016,9
TPOX9,11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=1699657
Masayuki Towatari, Yoshinori Ito, Yoshihisa Morishita, Mitsune Tanimoto, Kohei Kawashima, Yasuo Morishima, Toshiwo Andoh, Hidehiko Saito;
Enhanced expression of DNA topoisomerase II by recombinant human granulocyte colony-stimulating factor in human leukemia cells.
Cancer Res. 50:7198-7202(1990)

PubMed=1701353
Takae Kataoka, Yoshihisa Morishita, Michinori Ogura, Yasuo Morishima, Masayuki Towatari, Yukio Kato, Hideo Inoue, Hidehiko Saito;
A novel human myeloid leukemia cell line, NKM-1, coexpressing granulocyte colony-stimulating factor receptors and macrophage colony-stimulating factor receptors.
Cancer Res. 50:7703-7709(1990)

PubMed=1701357
Yoshihisa Morishita, Takae Kataoka, Masayuki Towatari, Takahiko Ito, Hideo Inoue, Michinori Ogura, Yasuo Morishima, Hidehiko Saito;
Up-regulation of transferrin receptor gene expression by granulocyte colony-stimulating factor in human myeloid leukemia cells.
Cancer Res. 50:7955-7961(1990)

PubMed=9737686; DOI=10.1038/sj.leu.2401112
Wen-Ji Zhang, Kazunori Ohnishi, Kazuyuki Shigeno, Shinya Fujisawa, Kensuke Naito, Satoki Nakamura, Kenzo Takeshita, Akihiro Takeshita, Ryuzo Ohno;
The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms.
Leukemia 12:1383-1391(1998)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886
Jun Takizawa, Ritsuro Suzuki, Hiroyuki Kuroda, Atae Utsunomiya, Yoshitoyo Kagami, Tatsuroh Joh, Yoshifusa Aizawa, Ryuzo Ueda, Masao Seto;
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; IFO50476
Cell line databases/resources CLO; CLO_0009850
cancercelllines; CVCL_1607
Cell_Model_Passport; SIDM00576
Cosmic-CLP; 908448
DepMap; ACH-002290
LINCS_LDP; LCL-1073
Biological sample resources BioSample; SAMN03472796
Chemistry resources ChEMBL-Cells; CHEMBL3308212
ChEMBL-Targets; CHEMBL2366133
GDSC; 908448
PharmacoDB; NKM1_1161_2019
PubChem_Cell_line; CVCL_1607
Encyclopedic resources Wikidata; Q54930681
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10765-110E9
GEO; GSM1670279
Polymorphism and mutation databases Cosmic; 908448
Cosmic; 1523824
Cosmic; 2131549
Cosmic; 2306228
IARC_TP53; 21586
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number36