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Cellosaurus NCI-H1184 (CVCL_1458)

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Cell line name NCI-H1184
Synonyms H1184; H-1184; NCIH1184
Accession CVCL_1458
Resource Identification Initiative To cite this cell line use: NCI-H1184 (RRID:CVCL_1458)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: ~50-70 hours (DSMZ=ACC-502).
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Donor information: Established from a 75 packs per year smoker (ATCC=CRL-5858).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*03:01,68:02
HLA-BB*07:02,07:02
HLA-CC*04:01,08:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.45
Native American0.52
East Asian, North0.92
East Asian, South0
South Asian0.72
European, North65.61
European, South31.77
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2635 ! NCI-BL1184
Sex of cell Male
Age at sampling 42Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-5858; DSMZ=ACC-502; PubMed=20679594; PubMed=24586258

Markers:
AmelogeninX,Y
CSF1PO10
D2S133818,20
D3S135814
D5S81812
D7S82010,12 (ATCC=CRL-5858; DSMZ=ACC-502; PubMed=24586258)
12 (PubMed=20679594)
D8S117910,11
D13S31711
D16S53911 (PubMed=24586258)
11,12 (ATCC=CRL-5858; DSMZ=ACC-502; PubMed=20679594)
D18S5116,20
D19S43312,14
D21S1132.2
FGA22
Penta D12
Penta E5,7
TH016,9.3
TPOX8,9
vWA16 (ATCC=CRL-5858)
16,17 (DSMZ=ACC-502; PubMed=20679594; PubMed=24586258)

Run an STR similarity search on this cell line
Publications

PubMed=1312696
Domenico D'Amico, David P. Carbone, Tetsuya Mitsudomi, Marion M. Nau, Joseph Fedorko, Edward Russell, Britt Johnson, Dotothy L. Buchhagen, Sara M. Bodner, Ruby M. Phelps, Adi F. Gazdar, John D. Minna;
High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors.
Oncogene 7:339-346(1992)

PubMed=1565469
Sara M. Bodner, John D. Minna, Sandra M. Jensen, Domenico D'Amico, David P. Carbone, Tetsuya Mitsudomi, Joseph Fedorko, Dotothy L. Buchhagen, Marion M. Nau, Adi F. Gazdar, Ritva Ilona Linnoila;
Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation.
Oncogene 7:743-749(1992)

PubMed=8806092; DOI=10.1002/jcb.240630505
Ruby M. Phelps, Bruce E. Johnson, Daniel C. Ihde, Adi F. Gazdar, David P. Carbone, Patrick R. McClintock, Ritva Ilona Linnoila, Mary J. Matthews, Paul A. Bunn Jr., Desmond Niall Carney, John D. Minna, James L. Mulshine;
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. Suppl. 24:32-91(1996)

PubMed=8806103; DOI=10.1002/jcb.240630516
Bruce E. Johnson, Edward Russell, Alfreda M. Simmons, Ruby M. Phelps, Seth M. Steinberg, Daniel C. Ihde, Adi F. Gazdar;
MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer.
J. Cell. Biochem. Suppl. 24:210-217(1996)

PubMed=9559342; DOI=10.1002/(SICI)1098-2264(199804)21:4<308::AID-GCC4>3.0.CO;2-2
Arvind K. Virmani, Kwun M. Fong, Dulmini R. Kodagoda, Donald McIntire, Jaclyn Y. Hung, Vijay Tonk, John D. Minna, Adi F. Gazdar;
Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types.
Genes Chromosomes Cancer 21:308-319(1998)

PubMed=10987304
Luc Girard, Sabine Zochbauer-Muller, Arvind K. Virmani, Adi F. Gazdar, John D. Minna;
Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.
Cancer Res. 60:4894-4906(2000)

PubMed=11030152; DOI=10.1038/sj.onc.1203815
Sanjay Modi, Akihito Kubo, Herbert Kazuto Oie, Amy B. Coxon, Ahad Rehmatulla, Frederic J. Kaye;
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)

PubMed=11314036; DOI=10.1038/sj.onc.1204211
Eva Forgacs, Jonathan D. Wren, Craig Kamibayashi, Masashi Kondo, Xie L. Xu, Sanford David Markowitz, Gail E. Tomlinson, Carolyn Y. Muller, Adi F. Gazdar, Harold Ray Garner, John D. Minna;
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Oncogene 20:1005-1009(2001)

PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680
Reika Iwakawa, Takashi Kohno, Masatoshi Enari, Tohru Kiyono, Jun Yokota;
Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.
Cancer Sci. 101:1891-1896(2010)

PubMed=20679594; DOI=10.1093/jnci/djq279; PMCID=PMC2935474
Adi F. Gazdar, Luc Girard, William W. Lockwood, Wan L. Lam, John D. Minna;
Lung cancer cell lines as tools for biomedical discovery and research.
J. Natl. Cancer Inst. 102:1310-1321(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23716474; DOI=10.1002/gcc.22076; PMCID=PMC3806277
Reika Iwakawa, Masataka Takenaka, Takashi Kohno, Yoko Shimada, Yasushi Totoki, Tatsuhiro Shibata, Koji Tsuta, Ryo Nishikawa, Masayuki Noguchi, Aiko Sato-Otsubo, Seishi Ogawa, Jun Yokota;
Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer.
Genes Chromosomes Cancer 52:802-816(2013)

PubMed=24586258; DOI=10.1371/journal.pone.0086910; PMCID=PMC3938400
Tamara Murmann-Konda, Carmen Carrillo-Garcia, Nadine Veit, Cornelius Courts, Alexander Glassmann, Viktor Janzen, Burkhard Madea, Markus Reinartz, Anne Harzen, Michael Nowak, Sven Perner ...Show all 13 authors... , Jochen Winter, Rainer Probstmeier; Show fewer authors
Staurosporine and extracellular matrix proteins mediate the conversion of small cell lung carcinoma cells into a neuron-like phenotype.
PLoS ONE 9:e86910.1-e86910.14(2014)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084
James L. Mulshine, Peter Ujhazy, Melissa Antman, Christine M. Burgess, Igor A. Kuzmin, Paul A. Bunn Jr., Bruce E. Johnson, Jack Alan Roth, Harvey I. Pass, Sheila M. Ross, Carolyn R. Aldige ...Show all 13 authors... , Ignacio Ivan Wistuba, John D. Minna; Show fewer authors
From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
J. Cell. Biochem. 121:3986-3999(2020)

PubMed=39154123; DOI=10.1038/s41388-024-03125-x; PMCID=PMC11405284
Aiden Nguyen, Clarissa G. Nunez, Tram Anh Tran, Luc Girard, Michael Peyton, Rodrigo Catalan, Cristina D. Guerena, Kimberley Avila, Benjamin J. Drapkin, Raghav Chandra, John D. Minna, Elisabeth D. Martinez;
Jumonji histone demethylases are therapeutic targets in small cell lung cancer.
Oncogene 43:2885-2899(2024)

Cross-references
Cell line collections (Providers) ATCC; CRL-5858
DSMZ; ACC-502
Cell line databases/resources CLO; CLO_0007983
cancercelllines; CVCL_1458
Cell_Model_Passport; SIDM01679
DepMap; ACH-000523
DSMZCellDive; ACC-502
Biological sample resources BioSample; SAMN03472574
BioSample; SAMN03473568
BioSample; SAMN10987606
Chemistry resources GDSC; 688000
PharmacoDB; NCIH1184_1004_2019
Encyclopedic resources Wikidata; Q54907775
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM171840
GEO; GSM171841
GEO; GSM794309
GEO; GSM844616
GEO; GSM845539
GEO; GSM887354
GEO; GSM888432
Polymorphism and mutation databases Cosmic; 688000
Cosmic; 852001
Cosmic; 877218
Cosmic; 980943
Cosmic; 1032412
Cosmic; 1518089
Cosmic; 1891910
Cosmic; 2125225
Cosmic; 2560233
Cosmic; 2628356
IARC_TP53; 426
LiGeA; CCLE_745
Progenetix; CVCL_1458
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number43