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Cellosaurus MZ-MEL-2 (CVCL_1435)

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Cell line name MZ-MEL-2
Synonyms Mz-Mel-2; MZ Mel 2; MZ-2 Mel; MZ2-MEL; MZ2-Mel; MZ2-mel; MZ2MEL
Accession CVCL_1435
Resource Identification Initiative To cite this cell line use: MZ-MEL-2 (RRID:CVCL_1435)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Abdomen; UBERON=UBERON_0000916.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (PubMed=25728708; Cosmic-CLP=971777; DepMap=ACH-002165).
  • Mutation; HGNC; HGNC:9829; RAF1; Simple; p.Ser257Leu (c.770C>T); ClinVar=VCV000013957; Zygosity=Heterozygous (Cosmic-CLP=971777; DepMap=ACH-002165).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.15
East Asian, North0.41
East Asian, South0.66
South Asian0.41
European, North64.57
European, South33.8
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C5U4 (MZ2-MEL.3.0)
Originate from same individual CVCL_C5U5 ! MZ2-EBV
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=971777

Markers:
AmelogeninX
CSF1PO10
D5S8189,11
D7S82010,12
D13S31712
D16S53912,13
TH018,9.3
TPOX8,12
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=3972469; DOI=10.1002/ijc.2910350215
Francoise M.Y.R. Vessiere-Louveaux, Martine Darville, Alexander Knuth, Thierry Boon;
Use of irradiated mouse fibroblasts to improve the cloning and adaptation to culture of human melanoma cells.
Int. J. Cancer 35:231-235(1985)

PubMed=2529220; DOI=10.1002/ijc.2910440413
Benoit J. van den Eynde, Philippe Hainaut, Michel Herin, Alexander Knuth, Carine Lemoine, Patrick Weynants, Pierre van der Bruggen, Rene Fauchet, Thierry Boon;
Presence on a human melanoma of multiple antigens recognized by autologous CTL.
Int. J. Cancer 44:634-640(1989)

PubMed=8509230; DOI=10.1002/ijc.2910540329
Donata Rimoldi, Pedro Romero, Stefan Carrel;
The human melanoma antigen-encoding gene, MAGE-1, is expressed by other tumour cells of neuroectodermal origin such as glioblastomas and neuroblastomas.
Int. J. Cancer 54:527-528(1993)

PubMed=8566071; DOI=10.1002/eji.1830260135
Vincent G. Brichard, Jean Herman, Aline Van Pel, Claude Wildmann, Beatrice Gaugler, Thomas Wolfel, Thierry Boon, Bernard Lethe;
A tyrosinase nonapeptide presented by HLA-B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes.
Eur. J. Immunol. 26:224-230(1996)

PubMed=9637538; DOI=10.4049/jimmunol.160.12.6188
Maryse Gueguen, Jean-Jacques Patard, Beatrice Gaugler, Francis Brasseur, Jean-Christophe Renauld, Paul J. Van Cangh, Thierry Boon, Benoit J. van den Eynde;
An antigen recognized by autologous CTLs on a human bladder carcinoma.
J. Immunol. 160:6188-6194(1998)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=25502142; DOI=10.1038/ncomms6712; PMCID=PMC4428333
Judith Muller, Oscar Krijgsman, Jennifer Tsoi, Lidia Robert, Willy Hugo, Chunying Song, Xiang-Ju Kong, Patricia Abrao Possik, Paulien D.M. Cornelissen-Steijger, Marnix H. Geukes Foppen, Kristel Kemper ...Show all 19 authors... , Colin Ronald Goding, Ultan McDermott, Christian Blank, John B.A.G. Haanen, Thomas G. Graeber, Antoni Ribas, Roger S. Lo, Daniel S. Peeper; Show fewer authors
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.
Nat. Commun. 5:5712.1-5712.15(2014)

PubMed=25728708; DOI=10.1111/pcmr.12364
Celia J. Vogel, Marjon A. Smit, Gianluca Maddalo, Patricia Abrao Possik, Rolf W. Sparidans, Sjoerd H. van der Burg, Elizabeth M.E. Verdegaal, Albert J.R. Heck, Ahmed A. Samatar, Jos Heindrik Beijnen, A.F. Maarten Altelaar, Daniel S. Peeper;
Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.
Pigment Cell Melanoma Res. 28:307-317(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resources CLO; CLO_0037132
cancercelllines; CVCL_1435
Cell_Model_Passport; SIDM00179
Cosmic-CLP; 971777
DepMap; ACH-002165
LINCS_LDP; LCL-1278
Chemistry resources ChEMBL-Cells; CHEMBL3308272
ChEMBL-Targets; CHEMBL2366226
GDSC; 971777
PharmacoDB; MZ2MEL_976_2019
PubChem_Cell_line; CVCL_1435
Encyclopedic resources Wikidata; Q54907223
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1507939
GEO; GSM1670140
Polymorphism and mutation databases Cosmic; 971777
IARC_TP53; 27565
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37