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Cellosaurus MSTO-211H (CVCL_1430)

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Cell line name MSTO-211H
Synonyms MSTO-211 H; MSTO211H; MSTO-211; 211H; MeSoTheliOma-211H
Accession CVCL_1430
Resource Identification Initiative To cite this cell line use: MSTO-211H (RRID:CVCL_1430)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MYC genetic alteration cell panel (ATCC TCP-1035).
Population: Caucasian.
Doubling time: 20 hours (PubMed=2840315); 20 hours (CLS=300450); ~30-40 hours (DSMZ=ACC-390).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=16630136).
  • Gene fusion; HGNC; HGNC:6514; LATS1 + HGNC; HGNC:9508; PSEN1; Name(s)=LATS1-PSEN1 (PubMed=25902174).
  • Mutation; HGNC; HGNC:6515; LATS2; Simple; p.Met785_Leu798del14 (c.2355_2396del42); Zygosity=Heterozygous (PubMed=21245096; Cosmic-CLP=908152; DepMap=ACH-000335).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,03:01
HLA-BB*07:02,39:01
HLA-CC*07:02,07:02
Class II
HLA-DRDRB1*01:02,01:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.17
East Asian, North1.28
East Asian, South0
South Asian2.13
European, North62.92
European, South33.49
Disease Pleural biphasic mesothelioma (NCIt: C45665)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E0ZC (Ubigene MSTO-211H LDHA KO)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2081; CLS=300450; Cosmic-CLP=908152; DSMZ=ACC-390; Technion Genomics Center

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133820,24
D3S135815
D5S81812
D7S8208,12
D8S117913
D13S31711,14
D16S53913
D18S5116,18 (ATCC=CRL-2081; CLS=300450; DSMZ=ACC-390)
18,19 (Technion Genomics Center)
D19S43313,14
D21S1128,31
FGA21
Penta D11,12
Penta E7,13
TH018,9.3
TPOX11
vWA16,18

Run an STR similarity search on this cell line
Web pages Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/other-bladder-cervical/msto-211h-xenograft-model/
Publications

PubMed=2840315; DOI=10.1111/j.1432-0436.1988.tb00806.x
Gerold Bepler, Angelika Koehler, Paul Kiefer, Klaus Havemann, Karin Beisenherz, Gabriele Jaques, Claw Gropp, Maria Haeder;
Characterization of the state of differentiation of six newly established human non-small-cell lung cancer cell lines.
Differentiation 37:158-171(1988)

PubMed=15920167; DOI=10.1016/S0002-9440(10)62492-3; PMCID=PMC1363736
Gavin J. Gordon, Graham N. Rockwell, Roderick V. Jensen, James George Rheinwald, Jonathan Neil Glickman, Joshua Paul Aronson, Brian J. Pottorf, Matthew David Nitz, William G. Richards, David John Sugarbaker, Raphael Bueno;
Identification of novel candidate oncogenes and tumor suppressors in malignant pleural mesothelioma using large-scale transcriptional profiling.
Am. J. Pathol. 166:1827-1840(2005)

PubMed=16630136; DOI=10.1111/j.1349-7006.2006.00184.x; PMCID=PMC11158456
Noriyasu Usami, Takayuki Fukui, Masashi Kondo, Tetsuo Taniguchi, Toshihiko Yokoyama, Shoichi Mori, Kohei Yokoi, Yoshitsugu Horio, Kaoru Shimokata, Yoshitaka Sekido, Toyoaki Hida;
Establishment and characterization of four malignant pleural mesothelioma cell lines from Japanese patients.
Cancer Sci. 97:387-394(2006)

PubMed=17270034; DOI=10.1111/j.1349-7006.2006.00386.x; PMCID=PMC11158069
Tetsuo Taniguchi, Sivasundaram Karnan, Takayuki Fukui, Toshihiko Yokoyama, Hiroyuki Tagawa, Kohei Yokoi, Yuichi Ueda, Tetsuya Mitsudomi, Yoshitsugu Horio, Toyoaki Hida, Yasushi Yatabe ...Show all 13 authors... , Masao Seto, Yoshitaka Sekido; Show fewer authors
Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32.
Cancer Sci. 98:438-446(2007)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21245096; DOI=10.1158/0008-5472.CAN-10-2164
Hideki Murakami, Tetsuya Mizuno, Tetsuo Taniguchi, Makiko Fujii, Futoshi Ishiguro, Takayuki Fukui, Shinya Akatsuka, Yoshitsugu Horio, Toyoaki Hida, Yutaka Kondo, Shinya Toyokuni ...Show all 13 authors... , Hirotaka Osada, Yoshitaka Sekido; Show fewer authors
LATS2 is a tumor suppressor gene of malignant mesothelioma.
Cancer Res. 71:873-883(2011)

PubMed=21642991; DOI=10.1038/ng.855; PMCID=PMC4643098
Matthew J. Bott, Marie Brevet, Barry Stephen Taylor, Shigeki Shimizu, Tatsuo Ito, Lu Wang, Jenette Creaney, Richard A. Lake, Maureen F. Zakowski, Boris A. Reva, Chris Sander ...Show all 18 authors... , Robert Delsite, Simon N. Powell, Qin Zhou, Rong-Lai Shen, Adam B. Olshen, Valerie W. Rusch, Marc Ladanyi; Show fewer authors
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.
Nat. Genet. 43:668-672(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24926545; DOI=10.1097/JTO.0000000000000202; PMCID=PMC4287384
Erick Riquelme, Milind Bhalchandra Suraokar, Jaime Rodriguez, Barbara Mino, Heather Y. Lin, David C. Rice, Anne Tsao, Ignacio Ivan Wistuba;
Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma.
J. Thorac. Oncol. 9:998-1007(2014)

PubMed=25902174; DOI=10.1097/JTO.0000000000000493
Akihiko Miyanaga, Mari Masuda, Koji Tsuta, Kumiko Kawasaki, Yuka Nakamura, Tomohiro Sakuma, Hisao Asamura, Akihiko Gemma, Tesshi Yamada;
Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.
J. Thorac. Oncol. 10:844-851(2015)

PubMed=26011428; DOI=10.1111/cas.12698; PMCID=PMC4556387
Shuhei Hakiri, Hirotaka Osada, Futoshi Ishiguro, Hideki Murakami, Yuko Murakami-Tonami, Kohei Yokoi, Yoshitaka Sekido;
Functional differences between wild-type and mutant-type BRCA1-associated protein 1 tumor suppressor against malignant mesothelioma cells.
Cancer Sci. 106:990-999(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28553954; DOI=10.1038/onc.2017.147
T. Kato, Tatsuhiro Sato, Kohei Yokoi, Yoshitaka Sekido;
E-cadherin expression is correlated with focal adhesion kinase inhibitor resistance in merlin-negative malignant mesothelioma cells.
Oncogene 36:5522-5531(2017)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-2081
CLS; 300450
DSMZ; ACC-390
ICLC; HL01018
Ubigene; YC-B014
Cell line databases/resources CLO; CLO_0007880
CLDB; cl7174
cancercelllines; CVCL_1430
CCRID; 3101HUMTCHu161
Cell_Model_Passport; SIDM00640
Cosmic-CLP; 908152
DepMap; ACH-000335
DSMZCellDive; ACC-390
LINCS_LDP; LCL-1776
Anatomy/cell type resources BTO; BTO_0002425
Biological sample resources BioSample; SAMN03471440
BioSample; SAMN10987652
BioSamples; SAMEA100779
Chemistry resources ChEMBL-Cells; CHEMBL3308116
ChEMBL-Targets; CHEMBL1075509
GDSC; 908152
PharmacoDB; MSTO211H_968_2019
PubChem_Cell_line; CVCL_1430
Encyclopedic resources Wikidata; Q54906900
Experimental variables resources EFO; EFO_0002839
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM49614
GEO; GSM726279
GEO; GSM827586
GEO; GSM850286
GEO; GSM887342
GEO; GSM888418
GEO; GSM1670136
Polymorphism and mutation databases Cosmic; 688057
Cosmic; 877275
Cosmic; 908152
Cosmic; 1067228
Cosmic; 1175876
Cosmic; 1481542
Cosmic; 1522772
Cosmic; 1541211
Cosmic; 1749563
Cosmic; 1963324
Cosmic; 1995515
Cosmic; 2759001
Cosmic; 2759223
IARC_TP53; 21518
LiGeA; CCLE_249
Progenetix; CVCL_1430
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number42