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Cellosaurus MS-1 [Human lung carcinoma] (CVCL_1429)

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Cell line name MS-1 [Human lung carcinoma]
Synonyms MS-1-L; MS1; Ms1
Accession CVCL_1429
Secondary accession CVCL_3031
Resource Identification Initiative To cite this cell line use: MS-1 [Human lung carcinoma] (RRID:CVCL_1429)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 45 hours (PubMed=9183634).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:9884; RB1; Simple; c.1128-2A>G; ClinVar=VCV000428715; Zygosity=Homozygous; Note=Splice acceptor mutation (Cosmic-CLP=753594; DepMap=ACH-001958).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly244Ser (c.730G>A); ClinVar=VCV000376600; Zygosity=Homozygous (PubMed=15901131; Cosmic-CLP=753594; DepMap=ACH-001958).
Genome ancestry Source: PubMed=30894373

Origin% genome
African9.93
Native American0.17
East Asian, North64.82
East Asian, South12.65
South Asian0
European, North5.2
European, South7.23
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=753594; JCRB=JCRB1081; PubMed=25877200; RCB=RCB0725

Markers:
AmelogeninX
CSF1PO10,13
D2S133823,25
D3S135816
D5S81812,13
D7S82011
D8S117915
D13S3179,12
D16S5399,11
D18S5113,17
D19S43314
D21S1129,30
FGA22,25
Penta D10
Penta E17,18
TH018,9.3
TPOX8
vWA14,19

Run an STR similarity search on this cell line
Publications

PubMed=9183634
Haruo Iguchi, Hideki Katakami, Noriyuki Masuda, Minoru Takada, Akira Kohno;
A PTHrP-producing cell line (MS-1) derived from human small cell lung carcinoma.
Hum. Cell 9:75-78(1996)

PubMed=15016488; DOI=10.1016/S0140-6736(04)15693-6
Michael H. Jones, Carl Virtanen, Daisuke Honjoh, Tatsu Miyoshi, Yukitoshi Satoh, Sakae Okumura, Ken Nakagawa, Hitoshi Nomura, Yuichi Ishikawa;
Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles.
Lancet 363:775-781(2004)

PubMed=15901131; DOI=10.1016/j.prp.2005.01.002
Yoshihiro Murai, Shinichi Hayashi, Hiroyuki Takahashi, Koichi Tsuneyama, Yasuo Takano;
Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
Pathol. Res. Pract. 201:109-115(2005)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22313637; DOI=10.4161/cbt.19238
Miyako Takata, Hiroki Chikumi, Naomi Miyake, Kaori Adachi, Yasunobu Kanamori, Akira Yamasaki, Tadashi Igishi, Naoto Burioka, Eiji Nanba, Eiji Shimizu;
Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity.
Cancer Biol. Ther. 13:369-378(2012)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=38639832; DOI=10.1007/s13577-024-01055-0; PMCID=PMC11194210
Fumio Kasai, Makoto Fukushima, Yohei Miyagi, Yukio Nakamura;
Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan.
Hum. Cell 37:944-950(2024)

Cross-references
Cell line collections (Providers) JCRB; JCRB1081
JCRB; NIHS0320 - Discontinued
JCRB; NIHS0353 - Discontinued
RCB; RCB0725
Cell line databases/resources CLO; CLO_0037031
CLO; CLO_0050048
cancercelllines; CVCL_1429
Cell_Model_Passport; SIDM00245
Cosmic-CLP; 753594
DepMap; ACH-001958
LINCS_LDP; LCL-1835
Biological sample resources BioSample; SAMN03470995
Chemistry resources ChEMBL-Cells; CHEMBL3308892
ChEMBL-Targets; CHEMBL2366125
GDSC; 753594
PharmacoDB; MS1_966_2019
PubChem_Cell_line; CVCL_1429
Encyclopedic resources Wikidata; Q54906752
Experimental variables resources EFO; EFO_0002836
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM17311
GEO; GSM827217
GEO; GSM1670134
Polymorphism and mutation databases Cosmic; 753594
Cosmic; 1212198
Cosmic; 1571744
Cosmic; 1656910
IARC_TP53; 21517
Progenetix; CVCL_1429
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number41