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Cellosaurus MS-1 [Human lung carcinoma] (CVCL_1429)

[Text version]

Cell line name MS-1 [Human lung carcinoma]
Synonyms MS-1-L; MS1; Ms1
Accession CVCL_1429
Secondary accession CVCL_3031
Resource Identification Initiative To cite this cell line use: MS-1 [Human lung carcinoma] (RRID:CVCL_1429)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 45 hours (PubMed=9183634).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations
  • Mutation; HGNC; 9884; RB1; Simple; c.1128-2A>G; ClinVar=VCV000428715; Zygosity=Homozygous; Note=Splice acceptor mutation (Cosmic-CLP; DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly244Ser (c.730G>A); ClinVar=VCV000376600; Zygosity=Homozygous (PubMed=15901131; Cosmic-CLP; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African9.93
Native American0.17
East Asian, North64.82
East Asian, South12.65
South Asian0
European, North5.2
European, South7.23
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; PubMed=25877200; RCB

Markers:
AmelogeninX
CSF1PO10,13
D2S133823,25
D3S135816
D5S81812,13
D7S82011
D8S117915
D13S3179,12
D16S5399,11
D18S5113,17
D19S43314
D21S1129,30
FGA22,25
Penta D10
Penta E17,18
TH018,9.3
TPOX8
vWA14,19

Run an STR similarity search on this cell line
Publications

PubMed=9183634
Iguchi H., Katakami H., Masuda N., Takada M., Kohno A.
A PTHrP-producing cell line (MS-1) derived from human small cell lung carcinoma.
Hum. Cell 9:75-78(1996)

PubMed=15016488; DOI=10.1016/S0140-6736(04)15693-6
Jones M.H., Virtanen C., Honjoh D., Miyoshi T., Satoh Y., Okumura S., Nakagawa K., Nomura H., Ishikawa Y.
Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles.
Lancet 363:775-781(2004)

PubMed=15901131; DOI=10.1016/j.prp.2005.01.002
Murai Y., Hayashi S., Takahashi H., Tsuneyama K., Takano Y.
Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
Pathol. Res. Pract. 201:109-115(2005)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22313637; DOI=10.4161/cbt.19238
Takata M., Chikumi H., Miyake N., Adachi K., Kanamori Y., Yamasaki A., Igishi T., Burioka N., Nanba E., Shimizu E.
Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity.
Cancer Biol. Ther. 13:369-378(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections JCRB; JCRB1081
JCRB; NIHS0320 - Discontinued
JCRB; NIHS0353 - Discontinued
RCB; RCB0725
Cell line databases/resources CLO; CLO_0050048
Cell_Model_Passport; SIDM00245
Cosmic-CLP; 753594
DepMap; ACH-001958
LINCS_LDP; LCL-1835
Biological sample resources BioSample; SAMN03470995
Chemistry resources ChEMBL-Cells; CHEMBL3308892
ChEMBL-Targets; CHEMBL2366125
GDSC; 753594
PharmacoDB; MS1_966_2019
PubChem_Cell_line; CVCL_1429
Encyclopedic resources Wikidata; Q54906752
Experimental variables resources EFO; EFO_0002836
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM17311
GEO; GSM827217
GEO; GSM1670134
Polymorphism and mutation databases Cosmic; 753594
Cosmic; 1212198
Cosmic; 1571744
Cosmic; 1656910
IARC_TP53; 21517
Progenetix; CVCL_1429
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update15-Dec-2022
Version number34