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Cellosaurus Lu-139 (CVCL_1390)

[Text version]
Cell line name Lu-139
Synonyms NCC-c-Lu-139; LU-139; Lu139; LU139
Accession CVCL_1390
Resource Identification Initiative To cite this cell line use: Lu-139 (RRID:CVCL_1390)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 29 hours (PubMed=3022030).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.34
Native American0
East Asian, North86.97
East Asian, South5.88
South Asian2.89
European, North2.93
European, South0
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=713878; RCB=RCB0469

Markers:
AmelogeninX,Y
CSF1PO11
D5S81813
D7S82012
D13S31711
D16S5399
TH019
TPOX8,12
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=3022030; DOI=10.1093/oxfordjournals.jjco.a039144
Takeo Terasaki, Yukio Shimosato, Takashi Nakajima, Masaru Tsumuraya, Shojiroh Morinaga, Setsuo Hirohashi, Ken Yamaguchi, Kanefusa Kato, Hiroshi Ichinose, Toshiharu Nagatsu;
Changes in cell characteristics due to culture conditions in cell lines from human small cell lung cancer.
Jpn. J. Clin. Oncol. 16:203-212(1986)

PubMed=1847845; DOI=10.1007/BF00685110
Yasutsuna Sasaki, Tetsu Shinkai, Kenji Eguchi, Tomohide Tamura, Yuichiro Ohe, Tohru Ohmori, Nagahiro Saijo;
Prediction of the antitumor activity of new platinum analogs based on their ex vivo pharmacodynamics as determined by bioassay.
Cancer Chemother. Pharmacol. 27:263-270(1991)

PubMed=1312700
Yuichi Sameshima, Yoshihiro Matsuno, Setsuo Hirohashi, Yukio Shimosato, Hideaki Mizoguchi, Takashi Sugimura, Masaaki Terada, Jun Yokota;
Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.
Oncogene 7:451-457(1992)

PubMed=8263009; DOI=10.1007/BF01202192
Tatsuhiko Kashii, Yutaka Mizushima, Satoshi Monno, K. Nakagawa, M. Kobayashi;
Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method.
J. Cancer Res. Clin. Oncol. 120:143-148(1994)

PubMed=10536175; DOI=10.3892/ijo.15.5.927
Takeshi Fujita, Masaharu Kiyama, Yoshio Tomizawa, Takashi Kohno, Jun Yokota;
Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.
Int. J. Oncol. 15:927-934(1999)

PubMed=11005564; DOI=10.1038/sj.neo.7900094; PMCID=PMC1550293
Takashi Kohno, Takako Sato, Satoshi Takakura, Kimiko Takei, Kaoru Inoue, Michiho Nishioka, Jun Yokota;
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=12107105; DOI=10.1016/S0002-9440(10)64172-7; PMCID=PMC1850681
Sana Yokoi, Kohichiroh Yasui, Fumiko Saito-Ohara, Katsumi Koshikawa, Toshihiko Iizasa, Takehiko Fujisawa, Takeo Terasaki, Akira Horii, Takashi Takahashi, Setsuo Hirohashi, Johji Inazawa;
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
Am. J. Pathol. 161:207-216(2002)

PubMed=15901131; DOI=10.1016/j.prp.2005.01.002
Yoshihiro Murai, Shinichi Hayashi, Hiroyuki Takahashi, Koichi Tsuneyama, Yasuo Takano;
Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines.
Pathol. Res. Pract. 201:109-115(2005)

PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846
Raquel Blanco, Reika Iwakawa, Mo-Ying Tang, Takashi Kohno, Barbara Angulo, Ruben Pio, Luis M. Montuenga, John D. Minna, Jun Yokota, Montse Sanchez-Cespedes;
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680
Reika Iwakawa, Takashi Kohno, Masatoshi Enari, Tohru Kiyono, Jun Yokota;
Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.
Cancer Sci. 101:1891-1896(2010)

PubMed=23716474; DOI=10.1002/gcc.22076; PMCID=PMC3806277
Reika Iwakawa, Masataka Takenaka, Takashi Kohno, Yoko Shimada, Yasushi Totoki, Tatsuhiro Shibata, Koji Tsuta, Ryo Nishikawa, Masayuki Noguchi, Aiko Sato-Otsubo, Seishi Ogawa, Jun Yokota;
Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer.
Genes Chromosomes Cancer 52:802-816(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=38639832; DOI=10.1007/s13577-024-01055-0; PMCID=PMC11194210
Fumio Kasai, Makoto Fukushima, Yohei Miyagi, Yukio Nakamura;
Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan.
Hum. Cell 37:944-950(2024)

Cross-references
Cell line collections (Providers) RCB; RCB0469
Cell line databases/resources CLO; CLO_0037023
CLO; CLO_0050031
cancercelllines; CVCL_1390
Cell_Model_Passport; SIDM00293
CGH-DB; 9063-4
CGH-DB; 93-1
Cosmic-CLP; 713878
DepMap; ACH-002052
LINCS_LDP; LCL-1872
Biological sample resources BioSample; SAMN03472318
Chemistry resources ChEMBL-Cells; CHEMBL3308238
ChEMBL-Targets; CHEMBL2366248
GDSC; 713878
PharmacoDB; LU139_867_2019
PubChem_Cell_line; CVCL_1390
Encyclopedic resources Wikidata; Q54903195
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670065
Polymorphism and mutation databases Cosmic; 713878
Cosmic; 801607
Cosmic; 809123
Cosmic; 844822
Cosmic; 876156
Cosmic; 918007
Cosmic; 929158
Cosmic; 1212195
Cosmic; 1239931
Cosmic; 1571751
Cosmic; 1995495
Cosmic; 2125268
Cosmic; 2668340
IARC_TP53; 1017
Proteomic databases PRIDE; PXD011896
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number41