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Cellosaurus LC-2/ad (CVCL_1373)

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Cell line name LC-2/ad
Synonyms LC-2-Ad; LC-2-ad; LC-2 ad; LC2/Ad; LC2/AD; LC2AD
Accession CVCL_1373
Resource Identification Initiative To cite this cell line use: LC-2/ad (RRID:CVCL_1373)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 58 hours (Note=At 32th passage) (PubMed=8291444).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Caution: Indicated to have a EGFR p.Leu858Arg (c.2573T>G) mutation according to PubMed=16105816) but this is in contradiction of results of exome sequencing in CCLE and Cosmic-CLP.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 18782; CCDC6 + HGNC; 9967; RET; Name(s)=CCDC6-RET, RET/PTC1 (PubMed=23578175).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser241Cys (c.722C>G); ClinVar=VCV000177791; Zygosity=Homozygous (Cosmic-CLP; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.63
East Asian, North76.2
East Asian, South13.98
South Asian0.14
European, North0.91
European, South4.65
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C4AM (LC-2/ad-cis)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; ECACC; RCB


Run an STR similarity search on this cell line

PubMed=8291444; DOI=10.1111/j.1440-1827.1993.tb03232.x
Kataoka H., Itoh H., Seguchi K., Koono M.
Establishment and characterization of a human lung adenocarcinoma cell line (LC-2/ad) producing alpha 1-antitrypsin in vitro.
Acta Pathol. Jpn. 43:566-573(1993)

PubMed=8348978; DOI=10.1016/0014-5793(93)80946-R
Kataoka H., Seguchi K., Inoue T., Koono M.
Properties of alpha 1-antitrypsin secreted by human adenocarcinoma cell lines.
FEBS Lett. 328:291-295(1993)

PubMed=16105816; DOI=10.1158/0008-5472.CAN-05-0331
Nagai Y., Miyazawa H., Huqun X., Tanaka T., Udagawa K., Kato M., Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K.
Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.
Cancer Res. 65:7276-7282(2005)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22313637; DOI=10.4161/cbt.19238
Takata M., Chikumi H., Miyake N., Adachi K., Kanamori Y., Yamasaki A., Igishi T., Burioka N., Nanba E., Shimizu E.
Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity.
Cancer Biol. Ther. 13:369-378(2012)

PubMed=23154560; DOI=10.1097/JTO.0b013e3182721ed1
Matsubara D., Kanai Y., Ishikawa S., Ohara S., Yoshimoto T., Sakatani T., Oguni S., Tamura T., Kataoka H., Endo S., Murakami Y., Aburatani H., Fukayama M., Niki T.
Identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line, LC-2/ad.
J. Thorac. Oncol. 7:1872-1876(2012)

PubMed=23578175; DOI=10.1111/cas.12175
Suzuki M., Makinoshima H., Matsumoto S., Suzuki A., Mimaki S., Matsushima K., Yoh K., Goto K., Suzuki Y., Ishii G., Ochiai A., Tsuta K., Shibata T., Kohno T., Esumi H., Tsuchihara K.
Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo.
Cancer Sci. 104:896-903(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cell line collections (Providers) ECACC; 94072247
RCB; RCB0440
Cell line databases/resources CLO; CLO_0037020
CLO; CLO_0050073
cancercelllines; CVCL_1373
Cell_Model_Passport; SIDM00297
Cosmic-CLP; 907786
DepMap; ACH-002157
Anatomy/cell type resources BTO; BTO:0006466
Biological sample resources BioSample; SAMN03472314
Chemistry resources ChEMBL-Cells; CHEMBL3308545
ChEMBL-Targets; CHEMBL2366260
GDSC; 907786
PharmacoDB; LC2ad_831_2019
PubChem_Cell_line; CVCL_1373
Encyclopedic resources Wikidata; Q54902124
Experimental variables resources EFO; EFO_0003140
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1670043
Polymorphism and mutation databases Cosmic; 907786
Cosmic; 946052
Cosmic; 1154602
Cosmic; 1571726
Cosmic; 1656903
Cosmic; 1995480
IARC_TP53; 21470
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number34