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Cellosaurus LB831-BLC (CVCL_1370)

[Text version]
Cell line name LB831-BLC
Synonyms LB831BLC; LB831
Accession CVCL_1370
Resource Identification Initiative To cite this cell line use: LB831-BLC (RRID:CVCL_1370)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
From: Ludwig Institute for Cancer Research, Brussels Branch; Brussels; Belgium.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser241Tyr (c.722C>A); ClinVar=VCV000376663; Zygosity=Homozygous (Cosmic-CLP=753584; DepMap=ACH-002266).
HLA typing Source: PubMed=9637538
Class I
HLA-AA*03,24:03
HLA-BB*44:03,49:01
HLA-CC*04:01,07
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.49
East Asian, North0
East Asian, South0.01
South Asian2.75
European, North63.52
European, South33.23
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_E913 ! LB831-EBV
Sex of cell Male
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=753584

Markers:
AmelogeninX
CSF1PO12
D5S81812,13
D7S82010,12
D13S3178
D16S53912
TH018,9
TPOX8,10
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=9637538; DOI=10.4049/jimmunol.160.12.6188
Maryse Gueguen, Jean-Jacques Patard, Beatrice Gaugler, Francis Brasseur, Jean-Christophe Renauld, Paul J. Van Cangh, Thierry Boon, Benoit J. van den Eynde;
An antigen recognized by autologous CTLs on a human bladder carcinoma.
J. Immunol. 160:6188-6194(1998)

PubMed=11051255
Jean-Luc Gala, Sylvain Loric, Yves Guiot, Samuel Ray Denmeade, Alyssa Gady, Francis Brasseur, Michel Heusterspreute, Pascal Eschwege, Philippe De Nayer, Paul J. Van Cangh, Bertrand Tombal;
Expression of prostate-specific membrane antigen in transitional cell carcinoma of the bladder: prognostic value?
Clin. Cancer Res. 6:4049-4054(2000)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350
Tahlita C.M. Zuiverloon, Florus C. de Jong, James C. Costello, Dan Theodorescu;
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resources CLO; CLO_0037159
cancercelllines; CVCL_1370
Cell_Model_Passport; SIDM00181
Cosmic-CLP; 753584
DepMap; ACH-002266
LINCS_LDP; LCL-1707
TOKU-E; 3997
Chemistry resources ChEMBL-Cells; CHEMBL3308853
ChEMBL-Targets; CHEMBL2366222
GDSC; 753584
PharmacoDB; LB831BLC_826_2019
PubChem_Cell_line; CVCL_1370
Encyclopedic resources Wikidata; Q54902093
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1670039
Polymorphism and mutation databases Cosmic; 753584
IARC_TP53; 21467
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37