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Cellosaurus L-428 (CVCL_1361)

[Text version]
Cell line name L-428
Synonyms L 428; L428
Accession CVCL_1361
Resource Identification Initiative To cite this cell line use: L-428 (RRID:CVCL_1361)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Population: Caucasian.
Doubling time: 42-46 hours (PubMed=7216541); ~35 hours (DSMZ=ACC-197).
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Cell surface proteome.
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Omics: Virome analysis using RNAseq.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 11896; TNFAIP3; Zygosity=Heterozygous (PubMed=19380639).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly112_Val122del11 (c.334_366del33); Zygosity=Heterozygous (PubMed=17065008; Cosmic-CLP).
HLA typing Source: PubMed=12133989
Class I
HLA-AA*03:01
HLA-BB*35:03
HLA-CC*04:01/03/05/07
Class II
HLA-DQDQB1*03:01/09
HLA-DRDRB1*12:01/06
DRB3*02

Source: PubMed=26589293
Class I
HLA-AA*03:01,03:01
HLA-BB*35:03,35:03
HLA-CC*04:01,04:01
Class II
HLA-DQDQA1*05:01,05:01
DQB1*03:01,03:01
HLA-DRDRB1*03:17,12:01

Source: DSMZCellDive=ACC-197
Class I
HLA-AA*03:01:01,03:01:01
HLA-BB*35:03:01,35:03:01
HLA-CC*04:01:01,04:01:01
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*04:01:01,04:01:01
HLA-DQDQA1*05:05:01,05:05:01
DQB1*03:01:01,03:01:01
HLA-DRDRA*01:02:02,01:02:02
DRB1*12:01:01,12:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.16
Native American0
East Asian, North3.23
East Asian, South0
South Asian0
European, North65.81
European, South28.79
Disease Hodgkin lymphoma (NCIt: C9357)
Hodgkin lymphoma (ORDO: Orphanet_98293)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_X206 (L-428 KS)
Sex of cell Female
Age at sampling 37Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ

Markers:
AmelogeninX
CSF1PO10,13
D2S133817,19
D3S135814,18
D5S81811,12
D7S82011
D8S117914
D13S31714
D16S53911,12
D18S5114
D19S43313,14
D21S1131.2
FGA19,25,26
Penta D8,9
Penta E10,17
TH017,9.3
TPOX8,9
vWA15

Run an STR similarity search on this cell line
Publications

PubMed=7216541; DOI=10.1002/ijc.2910260605
Schaadt M., Diehl V., Stein H., Fonatsch C., Kirchner H.H.
Two neoplastic cell lines with unique features derived from Hodgkin's disease.
Int. J. Cancer 26:723-731(1980)

PubMed=7276066; DOI=10.1007/BF00405072
Diehl V., Kirchner H.H., Schaadt M., Fonatsch C., Stein H., Gerdes J., Boie C.
Hodgkin's disease: establishment and characterization of four in vitro cell lines.
J. Cancer Res. Clin. Oncol. 101:111-124(1981)

PubMed=6303739; DOI=10.1055/s-2008-1069671
Kirchner H.H., Burrichter H., Stein H., Fonatsch C., Schaadt M., Ziegler A., Heit W., Diehl V.
Properties of Hodgkin cell lines. Possible significance for pathophysiology and clinical medicine.
Dtsch. Med. Wochenschr. 108:936-944(1983)

PubMed=6305805; DOI=10.1007/978-3-642-68761-7_81
Diehl V., Burrichter H., Schaadt M., Kirchner H.H., Fonatsch C., Stein H., Gerdes J., Heit W., Ziegler A.
Hodgkin's disease cell lines: characteristics and biological activities.
Haematol. Blood Transfus. 28:411-417(1983)

PubMed=3713248; DOI=10.1016/0145-2126(86)90084-6
Drexler H.G., Gaedicke G., Lok M.-S., Diehl V., Minowada J.
Hodgkin's disease derived cell lines HDLM-2 and L-428: comparison of morphology, immunological and isoenzyme profiles.
Leuk. Res. 10:487-500(1986)

PubMed=2898211
Newcom S.R., Kadin M.E., Ansari A.A.
Production of transforming growth factor-beta activity by Ki-1 positive lymphoma cells and analysis of its role in the regulation of Ki-1 positive lymphoma growth.
Am. J. Pathol. 131:569-577(1988)

PubMed=2690233; DOI=10.1007/978-3-642-83781-4_5
Schaadt M., Burrichter H., Pfreundschuh M., Schell-Frederick E., Tesch H., Fonatsch C., Stein H., Diehl V.
Biology of Hodgkin cell lines.
Recent Results Cancer Res. 117:53-61(1989)

PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x
Siebert R., Willers C.P., Schramm A., Fossa A., Dresen I.M.G., Uppenkamp M., Nowrousian M.R., Seeber S., Opalka B.
Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.
Br. J. Haematol. 91:350-354(1995)

PubMed=8558920
Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M., Quentmeier H., Drexler H.G.
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Leukemia 10:142-149(1996)

PubMed=9685479; DOI=10.1093/nar/26.16.3651
Hultdin M., Gronlund E., Norrback K.-F., Eriksson-Lindstrom E., Just T., Roos G.
Telomere analysis by fluorescence in situ hybridization and flow cytometry.
Nucleic Acids Res. 26:3651-3656(1998)

PubMed=9787181; DOI=10.1182/blood.V92.9.3410
Sakai A., Thieblemont C., Wellmann A., Jaffe E.S., Raffeld M.
PTEN gene alterations in lymphoid neoplasms.
Blood 92:3410-3415(1998)

PubMed=11021758; DOI=10.1038/sj.leu.2401891
Majka M., Rozmyslowicz T., Honczarenko M., Ratajczak J., Wasik M.A., Gaulton G.N., Ratajczak M.Z.
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Leukemia 14:1821-1832(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12133989; DOI=10.4049/jimmunol.169.3.1593
Paludan C., Bickham K., Nikiforow S., Tsang M.L., Goodman K., Hanekom W.A., Fonteneau J.-F., Stevanovic S., Munz C.
Epstein-Barr nuclear antigen 1-specific CD4(+) Th1 cells kill Burkitt's lymphoma cells.
J. Immunol. 169:1593-1603(2002)

PubMed=17065008; DOI=10.1080/10428190600667721
Feuerborn A., Moritz C., von Bonin F., Dobbelstein M., Trumper L., Sturzenhofecker B., Kube D.
Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma.
Leuk. Lymphoma 47:1932-1940(2006)

PubMed=19380639; DOI=10.1084/jem.20090528
Schmitz R., Hansmann M.-L., Bohle V., Martin-Subero J.I., Hartmann S., Mechtersheimer G., Klapper W., Vater I., Giefing M., Gesk S., Stanelle J., Siebert R., Kuppers R.
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.
J. Exp. Med. 206:981-989(2009)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20628145; DOI=10.1182/blood-2010-05-282780
Green M.R., Monti S., Rodig S.J., Juszczynski P., Currie T., O'Donnell E., Chapuy B., Takeyama K., Neuberg D., Golub T.R., Kutok J.L., Shipp M.A.
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.
Blood 116:3268-3277(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25355872; DOI=10.1128/JVI.02570-14
Cao S.-B., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z., O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
J. Virol. 89:713-729(2015)

PubMed=25894527; DOI=10.1371/journal.pone.0121314
Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A.S., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P.W., Wollscheid B.
A mass spectrometric-derived cell surface protein atlas.
PLoS ONE 10:E0121314-E0121314(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29533902; DOI=10.1515/hsz-2017-0321
Drexler H.G., Pommerenke C., Eberth S., Nagel S.
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.
Biol. Chem. 399:511-523(2018)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:E0210404-E0210404(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) CLS; 300200
DSMZ; ACC-197
Cell line databases/resources CLO; CLO_0007189
CLDB; cl3081
cancercelllines; CVCL_1361
Cell_Model_Passport; SIDM00327
Cosmic-CLP; 907322
DepMap; ACH-000754
DSMZCellDive; ACC-197
IGRhCellID; L428
LINCS_LDP; LCL-2011
Lonza; 924
Anatomy/cell type resources BTO; BTO:0000406
Biological sample resources BioSample; SAMN03473371
BioSample; SAMN10988569
Chemistry resources ChEMBL-Cells; CHEMBL3308873
ChEMBL-Targets; CHEMBL2366233
GDSC; 907322
PharmacoDB; L428_815_2019
PubChem_Cell_line; CVCL_1361
Encyclopedic resources Wikidata; Q54900867
Experimental variables resources EFO; EFO_0002225
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM499721
GEO; GSM499729
GEO; GSM552447
GEO; GSM637988
GEO; GSM887260
GEO; GSM888335
GEO; GSM1670029
Polymorphism and mutation databases Cosmic; 850218
Cosmic; 907322
Cosmic; 988703
Cosmic; 1013907
Cosmic; 1086358
Cosmic; 1278830
Cosmic; 1289698
Cosmic; 1432036
Cosmic; 1714161
Cosmic; 2276326
Cosmic; 2361389
Cosmic; 2464304
Cosmic; 2804876
IARC_TP53; 21455
IARC_TP53; 23612
LiGeA; CCLE_448
Progenetix; CVCL_1361
Proteomic databases PRIDE; PXD000589
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number40