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Cellosaurus L-428 (CVCL_1361)

[Text version]
Cell line name L-428
Synonyms L 428; L428
Accession CVCL_1361
Resource Identification Initiative To cite this cell line use: L-428 (RRID:CVCL_1361)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Population: Caucasian.
Doubling time: 42-46 hours (PubMed=7216541); ~35 hours (DSMZ=ACC-197).
Microsatellite instability: Instable (MSI-low) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Proteomics; Subcellular; Cell surface.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq virome analysis.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:11896; TNFAIP3; Zygosity=Heterozygous (PubMed=19380639).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly112_Val122del11 (c.334_366del33); Zygosity=Heterozygous (PubMed=17065008; Cosmic-CLP=907322).
HLA typing Source: PubMed=12133989
Class I
HLA-AA*03:01
HLA-BB*35:03
HLA-CC*04:01/03/05/07
Class II
HLA-DQDQB1*03:01/09
HLA-DRDRB1*12:01/06
DRB3*02

Source: PubMed=26589293
Class I
HLA-AA*03:01,03:01
HLA-BB*35:03,35:03
HLA-CC*04:01,04:01
Class II
HLA-DQDQA1*05:01,05:01
DQB1*03:01,03:01
HLA-DRDRB1*03:17,12:01

Source: DSMZCellDive=ACC-197
Class I
HLA-AA*03:01:01,03:01:01
HLA-BB*35:03:01,35:03:01
HLA-CC*04:01:01,04:01:01
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*04:01:01,04:01:01
HLA-DQDQA1*05:05:01,05:05:01
DQB1*03:01:01,03:01:01
HLA-DRDRA*01:02:02,01:02:02
DRB1*12:01:01,12:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.16
Native American0
East Asian, North3.23
East Asian, South0
South Asian0
European, North65.81
European, South28.79
Disease Hodgkin lymphoma (NCIt: C9357)
Hodgkin lymphoma (ORDO: Orphanet_98293)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_X206 (L-428 KS)
Sex of cell Female
Age at sampling 37Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=907322; DSMZ=ACC-197

Markers:
AmelogeninX
CSF1PO10,13
D2S133817,19
D3S135814,18
D5S81811,12
D7S82011
D8S117914
D13S31714
D16S53911,12
D18S5114
D19S43313,14
D21S1131.2
FGA19,25,26
Penta D8,9
Penta E10,17
TH017,9.3
TPOX8,9
vWA15

Run an STR similarity search on this cell line
Publications

PubMed=7216541; DOI=10.1002/ijc.2910260605
Michael Schaadt, Volker Diehl, Harald Stein, Christa Fonatsch, Hartmut H. Kirchner;
Two neoplastic cell lines with unique features derived from Hodgkin's disease.
Int. J. Cancer 26:723-731(1980)

PubMed=7276066; DOI=10.1007/BF00405072
Volker Diehl, Hartmut H. Kirchner, Michael Schaadt, Christa Fonatsch, Harald Stein, Johannes Gerdes, Christine Boie;
Hodgkin's disease: establishment and characterization of four in vitro cell lines.
J. Cancer Res. Clin. Oncol. 101:111-124(1981)

PubMed=6303739; DOI=10.1055/s-2008-1069671
Hartmut H. Kirchner, Heinz Burrichter, Harald Stein, Christa Fonatsch, Michael Schaadt, Andreas Ziegler, Wolfgang F.W. Heit, Volker Diehl;
Properties of Hodgkin cell lines. Possible significance for pathophysiology and clinical medicine.
Dtsch. Med. Wochenschr. 108:936-944(1983)

PubMed=6305805; DOI=10.1007/978-3-642-68761-7_81
Volker Diehl, Heinz Burrichter, Michael Schaadt, Hartmut H. Kirchner, Christa Fonatsch, Harald Stein, Johannes Gerdes, Wolfgang F.W. Heit, Andreas Ziegler;
Hodgkin's disease cell lines: characteristics and biological activities.
Haematol. Blood Transfus. 28:411-417(1983)

PubMed=3713248; DOI=10.1016/0145-2126(86)90084-6
Hans Gunther Drexler, Gerhard Gaedicke, Ming-Swang Lok, Volker Diehl, Jun Minowada;
Hodgkin's disease derived cell lines HDLM-2 and L-428: comparison of morphology, immunological and isoenzyme profiles.
Leuk. Res. 10:487-500(1986)

PubMed=2898211; PMCID=PMC1880714
Samuel R. Newcom, Marshall Edward Kadin, Aftab A. Ansari;
Production of transforming growth factor-beta activity by Ki-1 positive lymphoma cells and analysis of its role in the regulation of Ki-1 positive lymphoma growth.
Am. J. Pathol. 131:569-577(1988)

PubMed=2690233; DOI=10.1007/978-3-642-83781-4_5
Michael Schaadt, Heinz Burrichter, Michael Pfreundschuh, Elizabeth Schell-Frederick, Hans Tesch, Christa Fonatsch, Harald Stein, Volker Diehl;
Biology of Hodgkin cell lines.
Recent Results Cancer Res. 117:53-61(1989)

PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x
Reiner Siebert, Christoph P. Willers, Alexander Schramm, Alexander Fossa, Irina M. Gana Dresen, Michael J. Uppenkamp, Mohammad Resa Nowrousian, Siegfried Seeber, Bertram Opalka;
Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.
Br. J. Haematol. 91:350-354(1995)

PubMed=8558920
Wilhelm Gerhard Dirks, Margarete Zaborski, Kathrin Jager, Cecile Challier, Mami Shiota, Hilmar Quentmeier, Hans Gunther Drexler;
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Leukemia 10:142-149(1996)

PubMed=9685479; DOI=10.1093/nar/26.16.3651; PMCID=PMC147775
Magnus Hultdin, Elisabeth Gronlund, Karl-Frederik Norrback, E. Eriksson-Lindstrom, Tom Just, Goran Roos;
Telomere analysis by fluorescence in situ hybridization and flow cytometry.
Nucleic Acids Res. 26:3651-3656(1998)

PubMed=9787181; DOI=10.1182/blood.V92.9.3410
Akira Sakai, Catherine Thieblemont, Axel Wellmann, Elaine Sarkin Jaffe, Mark Raffeld;
PTEN gene alterations in lymphoid neoplasms.
Blood 92:3410-3415(1998)

PubMed=11021758; DOI=10.1038/sj.leu.2401891
Marcin Majka, Tomasz Rozmyslowicz, Marek J. Honczarenko, Janina Ratajczak, Mariusz A. Wasik, Glen N. Gaulton, Mariusz Zdzislaw Ratajczak;
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Leukemia 14:1821-1832(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=12133989; DOI=10.4049/jimmunol.169.3.1593
Casper Paludan, Kara Bickham, Sarah Nikiforow, Ming L. Tsang, Kiera Goodman, Willem A. Hanekom, Jean-Francois Fonteneau, Stefan Stevanovic, Christian Munz;
Epstein-Barr nuclear antigen 1-specific CD4(+) Th1 cells kill Burkitt's lymphoma cells.
J. Immunol. 169:1593-1603(2002)

PubMed=17065008; DOI=10.1080/10428190600667721
Alexander Feuerborn, Constanze Moritz, Frederike von Bonin, Matthias Dobbelstein, Lorenz Trumper, Benjamin Sturzenhofecker, Dieter Kube;
Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma.
Leuk. Lymphoma 47:1932-1940(2006)

PubMed=19380639; DOI=10.1084/jem.20090528; PMCID=PMC2715030
Roland Schmitz, Martin-Leo Hansmann, Verena Bohle, Jose Ignacio Martin-Subero, Sylvia Hartmann, Gunhild Mechtersheimer, Wolfram Klapper, Inga Vater, Maciej Giefing, Stefan Gesk, Jens Stanelle ...Show all 13 authors... , Reiner Siebert, Ralf Kuppers; Show fewer authors
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma.
J. Exp. Med. 206:981-989(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20628145; DOI=10.1182/blood-2010-05-282780; PMCID=PMC2995356
Michael Richard Green, Stefano Monti, Scott J. Rodig, Przemyslaw Juszczynski, Treeve Currie, Evan O'Donnell, Bjoern Chapuy, Kunihiko Takeyama, Donna Neuberg, Todd Robert Golub, Jeffery L. Kutok, Margaret Ann Shipp;
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.
Blood 116:3268-3277(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25355872; DOI=10.1128/JVI.02570-14; PMCID=PMC4301145
Su-Bing Cao, Michael J. Strong, Xia Wang, Walter N. Moss, Monica Concha, Zhen Lin, Tina O'Grady, Melody Baddoo, Claire Fewell, Rolf Renne, Erik K. Flemington;
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
J. Virol. 89:713-729(2015)

PubMed=25894527; DOI=10.1371/journal.pone.0121314; PMCID=PMC4404347
Damaris Bausch-Fluck, Andreas Hofmann, Thomas Bock, Andreas P. Frei, Ferdinando Cerciello, Andrea Jacobs, Hansjoerg Moest, Ulrich Omasits, Rebekah L. Gundry, Charles Yoon, Ralph Schiess ...Show all 20 authors... , Alexander Schmidt, Paulina Mirkowska, Anetta Svitorka Hartlova, Jennifer Eileen Van Eyk, Jean-Pierre Bourquin, Rudolf Aebersold, Kenneth R. Boheler, Peter W. Zandstra, Bernd Wollscheid; Show fewer authors
A mass spectrometric-derived cell surface protein atlas.
PLoS ONE 10:e0121314.1-e0121314.22(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29533902; DOI=10.1515/hsz-2017-0321
Hans Gunther Drexler, Claudia Pommerenke, Sonja Eberth, Stefan Nagel;
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.
Biol. Chem. 399:511-523(2018)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda ...Show all 14 authors... , De-Chen Lin, Henry He Yang, Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) CLS; 300200
DSMZ; ACC-197
Cell line databases/resources CLO; CLO_0007189
CLDB; cl3081
cancercelllines; CVCL_1361
Cell_Model_Passport; SIDM00327
Cosmic-CLP; 907322
DepMap; ACH-000754
DSMZCellDive; ACC-197
IGRhCellID; L428
LINCS_LDP; LCL-2011
Lonza; 924
Anatomy/cell type resources BTO; BTO_0000406
Biological sample resources BioSample; SAMN03473371
BioSample; SAMN10988569
Chemistry resources ChEMBL-Cells; CHEMBL3308873
ChEMBL-Targets; CHEMBL2366233
GDSC; 907322
PharmacoDB; L428_815_2019
PubChem_Cell_line; CVCL_1361
Encyclopedic resources Wikidata; Q54900867
Experimental variables resources EFO; EFO_0002225
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM499721
GEO; GSM499729
GEO; GSM552447
GEO; GSM637988
GEO; GSM887260
GEO; GSM888335
GEO; GSM1670029
Polymorphism and mutation databases Cosmic; 850218
Cosmic; 907322
Cosmic; 988703
Cosmic; 1013907
Cosmic; 1086358
Cosmic; 1278830
Cosmic; 1289698
Cosmic; 1432036
Cosmic; 1714161
Cosmic; 2276326
Cosmic; 2361389
Cosmic; 2464304
Cosmic; 2804876
IARC_TP53; 21455
IARC_TP53; 23612
LiGeA; CCLE_448
Progenetix; CVCL_1361
Proteomic databases PRIDE; PXD000589
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number44