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Cellosaurus KYSE-50 (CVCL_1360)

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Cell line name KYSE-50
Synonyms KYSE 50; KYSE50; KY-50
Accession CVCL_1360
Secondary accession CVCL_9821
Resource Identification Initiative To cite this cell line use: KYSE-50 (RRID:CVCL_1360)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 28.2 hours (PubMed=1728357); ~2-3 days (Note=Lot 02182005) (JCRB=JCRB0189).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Esophagus; UBERON=UBERON_0001043.
Sequence variations
  • Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Glu539Ter (c.1615G>T); Zygosity=Homozygous (Cosmic-CLP=1298222; DepMap=ACH-002264).
  • Mutation; HGNC; HGNC:667; RHOA; Simple; p.Gly17Val (c.50G>T); Zygosity=Heterozygous (Cosmic-CLP=1298222; DepMap=ACH-002264).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys101Ter (c.301A>T); Zygosity=Homozygous (Cosmic-CLP=1298222; DepMap=ACH-002264).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.31
Native American0
East Asian, North73.2
East Asian, South24.47
South Asian2.01
European, North0
European, South0
Disease Esophageal squamous cell carcinoma (NCIt: C4024)
Squamous cell carcinoma of the esophagus (ORDO: Orphanet_99977)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=1298222; JCRB=JCRB0189

Markers:
AmelogeninX
CSF1PO11,12 (JCRB=JCRB0189)
12 (Cosmic-CLP=1298222)
D5S81811
D7S82010
D13S31711
D16S53910,12
TH018
TPOX11
vWA17,19

Run an STR similarity search on this cell line
Publications

PubMed=1728357; DOI=10.1002/1097-0142(19920115)69:2<277::AID-CNCR2820690202>3.0.CO;2-C
Yutaka Shimada, Masayuki Imamura, Takashi Wagata, Nozomi Yamaguchi, Takayoshi Tobe;
Characterization of 21 newly established esophageal cancer cell lines.
Cancer 69:277-284(1992)

PubMed=7913084; DOI=10.1002/ijc.2910580224
Yuji Kanda, Yasuyuki Nishiyama, Yutaka Shimada, Masayuki Imamura, Hiroshi Nomura, Hiroshi Hiai, Manabu Fukumoto;
Analysis of gene amplification and overexpression in human esophageal-carcinoma cell lines.
Int. J. Cancer 58:291-297(1994)

PubMed=9033652; DOI=10.1002/(SICI)1097-0215(19970207)70:4<437::AID-IJC11>3.0.CO;2-C
Hisashi Tanaka, Yutaka Shimada, Masayuki Imamura, Ichio Shibagaki, Kanji Ishizaki;
Multiple types of aberrations in the p16 (INK4a) and the p15(INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines.
Int. J. Cancer 70:437-442(1997)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB0189
Cell line databases/resources CLO; CLO_0009934
cancercelllines; CVCL_1360
Cell_Model_Passport; SIDM00550
Cosmic-CLP; 1298222
DepMap; ACH-002264
LINCS_LDP; LCL-1560
Biological sample resources BioSample; SAMN03471649
Chemistry resources GDSC; 1298222
PharmacoDB; KYSE50_809_2019
Encyclopedic resources Wikidata; Q54900832
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827503
GEO; GSM1670023
Polymorphism and mutation databases Cosmic; 918522
Cosmic; 929520
Cosmic; 1043238
Cosmic; 1123334
Cosmic; 1581069
Cosmic; 1876250
Cosmic; 1995477
Cosmic; 2395006
Cosmic; 2650628
Progenetix; CVCL_1360
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37