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Cellosaurus KOSC-2 (CVCL_1337)

[Text version]

Cell line name KOSC-2
Synonyms KOSC2; KOSC-2 cl3-43; KOSC2CL343; Kobe university Oral Squamous Cell culture-2
Accession CVCL_1337
Resource Identification Initiative To cite this cell line use: KOSC-2 (RRID:CVCL_1337)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 18.7 hours (PubMed=8314315).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Oral cavity; floor of mouth.
Sequence variations
  • Mutation; HGNC; 667; RHOA; Simple; p.Arg5Gln (c.14G>A); ClinVar=VCV000376520; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
  • Mutation; HGNC; 667; RHOA; Simple; p.Glu40Gln (c.118G>C); ClinVar=VCV000376517; Zygosity=Heterozygous (Cosmic-CLP; DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln52delinsProTer (c.154_155insCAT); Zygosity=Heterozygous (Cosmic-CLP; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.44
Native American0
East Asian, North72.8
East Asian, South22.55
South Asian0
European, North0
European, South3.2
Disease Floor of mouth squamous cell carcinoma (NCIt: C4041)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DepMap; JCRB

Markers:
AmelogeninX
CSF1PO12
D3S135815
D5S8189
D7S82010,11
D8S117913,16
D13S31711
D16S5399,12
D18S5113
D21S1129,31
FGA21
Penta D9,10
Penta E15
TH016,7
TPOX8
vWA15,17

Run an STR similarity search on this cell line
Publications

PubMed=8314315; DOI=10.1002/ijc.2910560226
Inagaki T., Matsuwari S., Takahashi R., Shimada K.-K., Fujie K., Maeda S.
Establishment of human oral-cancer cell lines (KOSC-2 and -3) carrying p53 and c-myc abnormalities by geneticin treatment.
Int. J. Cancer 56:301-308(1994)

PubMed=17599052; DOI=10.1038/sj.onc.1210589
Suzuki E., Imoto I., Pimkhaokham A., Nakagawa T., Kamata N., Kozaki K.-I., Amagasa T., Inazawa J.
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Oncogene 26:7921-7932(2007)

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections JCRB; JCRB0126.1
Cell line databases/resources Cell_Model_Passport; SIDM00603
CGH-DB; 371-2
Cosmic-CLP; 753570
DepMap; ACH-001543
DepMap; ACH-002260 - Discontinued
LINCS_LDP; LCL-1227
Anatomy/cell type resources BTO; BTO:0005968
Biological sample resources BioSample; SAMN03470801
Chemistry resources ChEMBL-Cells; CHEMBL3308750
ChEMBL-Targets; CHEMBL1075481
GDSC; 753570
PharmacoDB; KOSC2_780_2019
PubChem_Cell_line; CVCL_1337
Encyclopedic resources Wikidata; Q54900341
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827195
GEO; GSM1670001
Polymorphism and mutation databases Cosmic; 753570
IARC_TP53; 21439
Progenetix; CVCL_1337
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update15-Dec-2022
Version number33