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Cellosaurus KOSC-2 (CVCL_1337)

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Cell line name KOSC-2
Synonyms KOSC2; KOSC-2 cl3-43; KOSC2CL343; Kobe university Oral Squamous Cell culture-2
Accession CVCL_1337
Resource Identification Initiative To cite this cell line use: KOSC-2 (RRID:CVCL_1337)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 18.7 hours (PubMed=8314315).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
Sequence variations
  • Mutation; HGNC; HGNC:667; RHOA; Simple; p.Arg5Gln (c.14G>A); ClinVar=VCV000376520; Zygosity=Heterozygous (Cosmic-CLP=753570; DepMap=ACH-001543).
  • Mutation; HGNC; HGNC:667; RHOA; Simple; p.Glu40Gln (c.118G>C); ClinVar=VCV000376517; Zygosity=Heterozygous (Cosmic-CLP=753570; DepMap=ACH-001543).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln52delinsProTer (c.154_155insCAT); Zygosity=Heterozygous (Cosmic-CLP=753570; DepMap=ACH-001543).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.44
Native American0
East Asian, North72.8
East Asian, South22.55
South Asian0
European, North0
European, South3.2
Disease Floor of mouth squamous cell carcinoma (NCIt: C4041)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=753570; DepMap=ACH-001543; JCRB=JCRB0126.1

Markers:
AmelogeninX
CSF1PO12
D3S135815
D5S8189
D7S82010,11
D8S117913,16
D13S31711
D16S5399,12
D18S5113
D21S1129,31
FGA21
Penta D9,10
Penta E15
TH016,7
TPOX8
vWA15,17

Run an STR similarity search on this cell line
Publications

PubMed=8314315; DOI=10.1002/ijc.2910560226
Toshiro Inagaki, Satoshi Matsuwari, Rei Takahashi, Kei-kichi Shimada, Kimiko Fujie, Sakan Maeda;
Establishment of human oral-cancer cell lines (KOSC-2 and -3) carrying p53 and c-myc abnormalities by geneticin treatment.
Int. J. Cancer 56:301-308(1994)

PubMed=17599052; DOI=10.1038/sj.onc.1210589
Emina Suzuki, Issei Imoto, Atiphan Pimkhaokham, Takayuki Nakagawa, Nobuyuki Kamata, Ken-ichi Kozaki, Teruo Amagasa, Johji Inazawa;
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Oncogene 26:7921-7932(2007)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB0126.1
Cell line databases/resources CLO; CLO_0009947
cancercelllines; CVCL_1337
Cell_Model_Passport; SIDM00603
CGH-DB; 371-2
Cosmic-CLP; 753570
DepMap; ACH-001543
DepMap; ACH-002260 - Discontinued
LINCS_LDP; LCL-1227
Anatomy/cell type resources BTO; BTO_0005968
Biological sample resources BioSample; SAMN03470801
Chemistry resources ChEMBL-Cells; CHEMBL3308750
ChEMBL-Targets; CHEMBL1075481
GDSC; 753570
PharmacoDB; KOSC2_780_2019
PubChem_Cell_line; CVCL_1337
Encyclopedic resources Wikidata; Q54900341
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827195
GEO; GSM1670001
Polymorphism and mutation databases Cosmic; 753570
IARC_TP53; 21439
Progenetix; CVCL_1337
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number39