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Cellosaurus KMOE-2 (CVCL_1332)

[Text version]
Cell line name KMOE-2
Synonyms KMOE2; Kmoe2
Accession CVCL_1332
Resource Identification Initiative To cite this cell line use: KMOE-2 (RRID:CVCL_1332)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 24.2 hours (PubMed=6949905); ~40-50 hours (DSMZ=ACC-37).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Heterozygous (Cosmic-CLP=907280; DepMap=ACH-002258).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val272Met (c.814G>A); ClinVar=VCV000185814; Zygosity=Homozygous (Cosmic-CLP=907280; DepMap=ACH-002258).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.41
Native American0.02
East Asian, North78.12
East Asian, South19.8
South Asian1.43
European, North0.23
European, South0
Disease Erythroleukemia (NCIt: C7152)
Acute erythroid leukemia (ORDO: Orphanet_318)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_UF71 (KMOE-2/05)
Originate from same individual CVCL_W022 ! KMOE-1
Sex of cell Female
Age at sampling 2Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=907280; DSMZ=ACC-37

Markers:
AmelogeninX
CSF1PO9,12
D2S133820,25
D3S135815,16
D5S8188,10
D7S82010
D8S117913,16
D13S3178,11
D16S5399,11
D18S5118,22
D19S43313,16
D21S1128,29
FGA19,22
Penta D11,12
Penta E11,12
TH016,9
TPOX9
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=6949905; DOI=10.1007/BF00410534
Hiromitsu Okano, Jun Okamura, Katsuro Yagawa, Hideko Tasaka, Seiji Motomura;
Human erythroid cell lines derived from a patient with acute erythremia.
J. Cancer Res. Clin. Oncol. 102:49-55(1981)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Hilmar Quentmeier, Roderick A.F. MacLeod, Margarete Zaborski, Hans Gunther Drexler;
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-37
Cell line databases/resources CLO; CLO_0007114
CLDB; cl3034
cancercelllines; CVCL_1332
Cell_Model_Passport; SIDM01019
Cosmic-CLP; 907280
DepMap; ACH-002258
DSMZCellDive; ACC-37
LINCS_LDP; LCL-1058
Biological sample resources BioSample; SAMN03473322
Chemistry resources ChEMBL-Cells; CHEMBL3308236
ChEMBL-Targets; CHEMBL2366347
GDSC; 907280
PharmacoDB; KMOE2_757_2019
PubChem_Cell_line; CVCL_1332
Encyclopedic resources Wikidata; Q54900132
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1446748
GEO; GSM1669991
Polymorphism and mutation databases Cosmic; 787445
Cosmic; 907280
Cosmic; 975262
Cosmic; 1012079
Cosmic; 1465969
Cosmic; 2131542
Cosmic; 2306213
IARC_TP53; 21434
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number41