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Cellosaurus IST-SL1 (CVCL_1313)

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Cell line name IST-SL1
Synonyms IST SL1; ISTSL1; Istituto Scientifico Tumori-Small cell Lung 1
Accession CVCL_1313
Resource Identification Initiative To cite this cell line use: IST-SL1 (RRID:CVCL_1313)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Supraclavicular lymph node; UBERON=UBERON_0035279.
Sequence variations
  • Mutation; HGNC; HGNC:9884; RB1; Simple; c.2520+1G>A; ClinVar=VCV000126805; Zygosity=Homozygous; Note=Splice donor mutation (Cosmic-CLP=753564; DepMap=ACH-002144).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.24
Native American0
East Asian, North0.16
East Asian, South1.69
South Asian0
European, North34.83
European, South63.08
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 60Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=753564; ICLC=HTL97012

Markers:
AmelogeninX
CSF1PO12
D5S81813
D7S8208,11
D13S3178
D16S53910
D21S1129,30
TH016,9
TPOX8
vWA15,17

Run an STR similarity search on this cell line
Publications

PubMed=8795583; DOI=10.1038/bjc.1996.437; PMCID=PMC2074713
Raffaella Meazza, Sabrina Marciano, Sabrina Sforzini, Anna Maria Orengo, M. Coppolecchia, Piero Musiani, Andrea Ardizzoni, Leonardo Santi, Bruno Azzarone, Silvano Ferrini;
Analysis of IL-2 receptor expression and of the biological effects of IL-2 gene transfection in small-cell lung cancer.
Br. J. Cancer 74:788-795(1996)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ICLC; HTL97012
Cell line databases/resources CLO; CLO_0006974
CLDB; cl2908
cancercelllines; CVCL_1313
Cell_Model_Passport; SIDM00223
Cosmic-CLP; 753564
DepMap; ACH-002144
LINCS_LDP; LCL-1868
Chemistry resources ChEMBL-Cells; CHEMBL3308263
ChEMBL-Targets; CHEMBL2366104
GDSC; 753564
PharmacoDB; ISTSL1_672_2019
PubChem_Cell_line; CVCL_1313
Encyclopedic resources Wikidata; Q54898350
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669944
Polymorphism and mutation databases Cosmic; 753564
Cosmic; 1995457
IARC_TP53; 27558
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37