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Cellosaurus IST-Mes2 (CVCL_1312)

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Cell line name IST-Mes2
Synonyms IST-MES2; IST-MES-2; ISTMES2; IstMes2; Istituto Scientifico Tumori-Mesothelioma 2
Accession CVCL_1312
Resource Identification Initiative To cite this cell line use: IST-Mes2 (RRID:CVCL_1312)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: TCGA-110-CL cell line panel.
Population: Caucasian.
Transformant: ChEBI; CHEBI_46661; Asbestos.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Homozygous (DepMap=ACH-000331).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*24:02,26:01
HLA-BB*38:01,39:01
HLA-CC*12:03,12:03
Class II
HLA-DQDQA1*03:02,05:01
DQB1*02:02,02:02
HLA-DRDRB1*03:03,10:04
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.1
East Asian, North2.01
East Asian, South0
South Asian2.87
European, North43.48
European, South51.54
Disease Pleural epithelioid mesothelioma (NCIt: C45662)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 71Y
Category Cancer cell line
STR profile Source(s): ICLC=HTL01007

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81812,13
D7S82010
D13S31713
D16S53911
D21S1128,29
TH019
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=10232421; DOI=10.1183/09031936.99.13352799
Anna Maria Orengo, Luciana Spoletini, Antonio Procopio, Roberto E. Favoni, Alessandra De Cupis, Andrea Ardizzoni, Bruno Castagneto, M. Ribotta, Pier Giorgio Betta, Silvano Ferrini, Luciano Mutti;
Establishment of four new mesothelioma cell lines: characterization by ultrastructural and immunophenotypic analysis.
Eur. Respir. J. 13:527-534(1999)

PubMed=16704740; DOI=10.1186/1471-2407-6-130; PMCID=PMC1483896
Daniele Martarelli, Alfonso Catalano, Antonio Procopio, Sara Orecchia, Roberta Libener, Giorgio Santoni;
Characterization of human malignant mesothelioma cell lines orthotopically implanted in the pleural cavity of immunodeficient mice for their ability to grow and form metastasis.
BMC Cancer 6:130.1-130.7(2006)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785
Katharine Yu, Bin Chen, Dvir Aran, Joe Charalel, Christina Yau, Douglas M. Wolf, Laura J. van 't Veer, Atul Janardhan Butte, Ted Goldstein, Marina Sirota;
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574.1-3574.11(2019)

Cross-references
Cell line collections (Providers) ICLC; HTL01007
Cell line databases/resources CLO; CLO_0006973
CLDB; cl5544
cancercelllines; CVCL_1312
Cell_Model_Passport; SIDM01554
DepMap; ACH-000331
Biological sample resources BioSample; SAMN10988152
Chemistry resources PharmacoDB; ISTMES2_671_2019
Encyclopedic resources Wikidata; Q54898348
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887166
GEO; GSM888238
GEO; GSM1029450
GEO; GSM1029451
GEO; GSM1029452
GEO; GSM1029453
GEO; GSM1029454
GEO; GSM1029455
GEO; GSM1029456
GEO; GSM1029457
GEO; GSM1029458
GEO; GSM1029459
Polymorphism and mutation databases IARC_TP53; 28300
LiGeA; CCLE_183
Progenetix; CVCL_1312
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number27