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Cellosaurus IST-Mes2 (CVCL_1312)

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Cell line name IST-Mes2
Synonyms IST-MES2; IST-MES-2; ISTMES2; IstMes2; Istituto Scientifico Tumori-Mesothelioma 2
Accession CVCL_1312
Resource Identification Initiative To cite this cell line use: IST-Mes2 (RRID:CVCL_1312)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: TCGA-110-CL cell line panel.
Population: Caucasian.
Transformant: ChEBI; CHEBI:46661; Asbestos.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Homozygous (DepMap=ACH-000331).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*24:02,26:01
HLA-BB*38:01,39:01
HLA-CC*12:03,12:03
Class II
HLA-DQDQA1*03:02,05:01
DQB1*02:02,02:02
HLA-DRDRB1*03:03,10:04
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.1
East Asian, North2.01
East Asian, South0
South Asian2.87
European, North43.48
European, South51.54
Disease Pleural epithelioid mesothelioma (NCIt: C45662)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 71Y
Category Cancer cell line
STR profile Source(s): ICLC=HTL01007

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81812,13
D7S82010
D13S31713
D16S53911
D21S1128,29
TH019
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=10232421; DOI=10.1183/09031936.99.13352799
Orengo A.M., Spoletini L., Procopio A., Favoni R.E., De Cupis A., Ardizzoni A., Castagneto B., Ribotta M., Betta P.G., Ferrini S., Mutti L.
Establishment of four new mesothelioma cell lines: characterization by ultrastructural and immunophenotypic analysis.
Eur. Respir. J. 13:527-534(1999)

PubMed=16704740; DOI=10.1186/1471-2407-6-130; PMCID=PMC1483896
Martarelli D., Catalano A., Procopio A., Orecchia S., Libener R., Santoni G.
Characterization of human malignant mesothelioma cell lines orthotopically implanted in the pleural cavity of immunodeficient mice for their ability to grow and form metastasis.
BMC Cancer 6:130.1-130.7(2006)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785
Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574.1-3574.11(2019)

Cross-references
Cell line collections (Providers) ICLC; HTL01007
Cell line databases/resources CLO; CLO_0006973
CLDB; cl5544
cancercelllines; CVCL_1312
Cell_Model_Passport; SIDM01554
DepMap; ACH-000331
Biological sample resources BioSample; SAMN10988152
Chemistry resources PharmacoDB; ISTMES2_671_2019
Encyclopedic resources Wikidata; Q54898348
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887166
GEO; GSM888238
GEO; GSM1029450
GEO; GSM1029451
GEO; GSM1029452
GEO; GSM1029453
GEO; GSM1029454
GEO; GSM1029455
GEO; GSM1029456
GEO; GSM1029457
GEO; GSM1029458
GEO; GSM1029459
Polymorphism and mutation databases IARC_TP53; 28300
LiGeA; CCLE_183
Progenetix; CVCL_1312
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number25