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Cellosaurus HSC-2 (CVCL_1287)

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Cell line name HSC-2
Synonyms HSC2
Accession CVCL_1287
Resource Identification Initiative To cite this cell line use: HSC-2 (RRID:CVCL_1287)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: ~38 hours (Note=Lot 012999), 27 hours (Note=Lot 07152004), 34 hours (Note=Lot 02172009), ~32 hours (Note=Lot 08082012), ~30 hours (Note=Lot 06192015), ~18 hours (Note=Lot 06192017), ~26 hours (Note=Lot 02082021) (JCRB=JCRB0622).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
Sequence variations
HLA typing Source: PubMed=9023415
Class I
HLA-AA*24:02,33:02
HLA-BB*44:03:01,54:01
HLA-CC*01:02,14:03

Source: PubMed=26589293
Class I
HLA-AA*24:02,33:03
HLA-BB*08:01,54:01
HLA-CC*01:02,14:03
Class II
HLA-DQDQA1*02:01,05:02
DQB1*06:08,06:08
HLA-DRDRB1*11:30,13:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.05
Native American0
East Asian, North83.8
East Asian, South14.71
South Asian1.36
European, North0
European, South0.07
Disease Oral cavity squamous cell carcinoma (NCIt: C4833)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=753562; JCRB=JCRB0622; PubMed=11416159; RCB=RCB1945; Technion Genomics Center; TKG=TKG 0487

Markers:
AmelogeninX (JCRB=JCRB0622)
X,Y (Cosmic-CLP=753562; PubMed=11416159; RCB=RCB1945; Technion Genomics Center; TKG=TKG 0487)
CSF1PO12,13
D1S165615,17,18
D2S44110
D2S133819
D3S135815,17
D5S81810,12
D7S8209,12
D8S117910,14
D10S124813
D12S39118
D13S31711,12
D16S53912
D18S5119
D19S43314
D21S1131.2
D22S104515
DYS39110
FGA19,21
Penta D9
Penta E12,15
TH016,7
TPOX8
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=2585303; DOI=10.1111/j.1600-0714.1989.tb01570.x
Fumio Momose, Toshio Araida, Akihide Negishi, Hidenori Ichijo, Setsuko Shioda, Satoshi Sasaki;
Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas.
J. Oral Pathol. Med. 18:391-395(1989)

PubMed=2228902; DOI=10.1007/BF02624609
Koichi Rikimaru, Hitomi Toda, Noriko Tachikawa, Nobuyuki Kamata, Shoji Enomoto;
Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium.
In Vitro Cell. Dev. Biol. 26:849-856(1990)

PubMed=1570156
Eiki Sakai, Nobuo Tsuchida;
Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes.
Oncogene 7:927-933(1992)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Naoko Seki, Tomoaki Hoshino, Megumi Kikuchi, Akihiro Hayashi, Kyogo Itoh;
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=10069537; DOI=10.1111/j.1600-0714.1999.tb02006.x
Toshiaki Hoteiya, Eiji Hayashi, Kazuhito Satomura, Nobuyuki Kamata, Masaru Nagayama;
Expression of E-cadherin in oral cancer cell lines and its relationship to invasiveness in SCID mice in vivo.
J. Oral Pathol. Med. 28:107-111(1999)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=11755821; DOI=10.1016/S1368-8375(01)00022-7
Yasufumi Niinaka, Arayo Haga, Akihide Negishi, Hidemi Yoshimasu, Avraham Raz, Teruo Amagasa;
Regulation of cell motility via high and low affinity autocrine motility factor (AMF) receptor in human oral squamous carcinoma cells.
Oral Oncol. 38:49-55(2002)

PubMed=12738951; DOI=10.1067/moe.2003.36
Masaru Sugiyama, Ujjal K. Bhawal, Tamiko Dohmen, Shigehiro Ono, Miwa Miyauchi, Takenori Ishikawa;
Detection of human papillomavirus-16 and HPV-18 DNA in normal, dysplastic, and malignant oral epithelium.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 95:594-600(2003)

PubMed=15800904; DOI=10.1002/ijc.21008
Takeyuki Tada, Eijiro Jimi, Masato Okamoto, Satoru Ozeki, Koji Okabe;
Oral squamous cell carcinoma cells induce osteoclast differentiation by suppression of osteoprotegerin expression in osteoblasts.
Int. J. Cancer 116:253-262(2005)

PubMed=17052259; DOI=10.1111/j.1349-7006.2006.00343.x; PMCID=PMC11160012
Ken-ichi Kozaki, Issei Imoto, Atiphan Pimkhaokham, Shogo Hasegawa, Hitoshi Tsuda, Ken Omura, Johji Inazawa;
PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma.
Cancer Sci. 97:1351-1358(2006)

PubMed=17325662; DOI=10.1038/sj.onc.1210330
K. Nakaya, Hidehisa D. Yamagata, Norimasa Arita, Koh-ichi Nakashiro, Masato Nose, Tetsuro Miki, Hiroyuki Hamakawa;
Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.
Oncogene 26:5300-5308(2007)

PubMed=17599052; DOI=10.1038/sj.onc.1210589
Emina Suzuki, Issei Imoto, Atiphan Pimkhaokham, Takayuki Nakagawa, Nobuyuki Kamata, Ken-ichi Kozaki, Teruo Amagasa, Johji Inazawa;
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Oncogene 26:7921-7932(2007)

PubMed=18097548; DOI=10.3892/ijo.32.1.101
Avaniyapuram Kannan Murugan, Nguyen Thi Hong, Yasuhisa Fukui, Arasambattu Kannan Munirajan, Nobuo Tsuchida;
Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas.
Int. J. Oncol. 32:101-111(2008)

PubMed=18973137; DOI=10.1002/gcc.20626
Takashi Sugimoto, Naohiko Seki, Satoya Shimizu, Naoko Kikkawa, Jun Tsukada, Hideaki Shimada, Keita Sasaki, Toyoyuki Hanazawa, Yoshitaka Okamoto, Akira Hata;
The galanin signaling cascade is a candidate pathway regulating oncogenesis in human squamous cell carcinoma.
Genes Chromosomes Cancer 48:132-142(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23992541; DOI=10.1111/cas.12271; PMCID=PMC7654248
Kazuaki Chikamatsu, Hiroki Ishii, Takaaki Murata, Koichi Sakakura, Masato Shino, Minoru Toyoda, Katsumasa Takahashi, Keisuke Masuyama;
Alteration of cancer stem cell-like phenotype by histone deacetylase inhibitors in squamous cell carcinoma of the head and neck.
Cancer Sci. 104:1468-1475(2013)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=32990596; DOI=10.7554/eLife.57761; PMCID=PMC7591259
Annie Wai-Yeeng Chai, Pei-San Yee, Stacey Price, Shi-Mun Yee, Hui-Mei Lee, Vivian K.H. Tiong, Emanuel Goncalves, Fiona M. Behan, Jessica Bateson, James G.R. Gilbert, Aik-Choon Tan ...Show all 14 authors... , Ultan McDermott, Mathew J. Garnett, Sok-Ching Cheong; Show fewer authors
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway.
eLife 9:e57761.1-e57761.34(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB0622
RCB; RCB1945
TKG; TKG 0487
Cell line databases/resources CLO; CLO_0051383
cancercelllines; CVCL_1287
Cell_Model_Passport; SIDM00590
CGH-DB; 358-2
Cosmic-CLP; 753562
DepMap; ACH-000472
LINCS_LDP; LCL-1206
Anatomy/cell type resources BTO; BTO_0003881
Biological sample resources BioSample; SAMN03471637
BioSample; SAMN03472038
BioSample; SAMN10987832
CRISP screens repositories BioGRID_ORCS_Cell_line; 1284
Chemistry resources ChEMBL-Cells; CHEMBL3308482
ChEMBL-Targets; CHEMBL1075468
GDSC; 753562
PharmacoDB; HSC2_619_2019
PubChem_Cell_line; CVCL_1287
Encyclopedic resources Wikidata; Q54076889
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM243521
GEO; GSM827233
GEO; GSM850382
GEO; GSM887133
GEO; GSM888204
GEO; GSM1669903
Polymorphism and mutation databases Cosmic; 753562
Cosmic; 930330
Cosmic; 932147
Cosmic; 1046027
Cosmic; 1118788
Cosmic; 1120697
Cosmic; 1123038
Cosmic; 1140780
Cosmic; 1219864
Cosmic; 1530743
Cosmic; 1571799
Cosmic; 2266783
Cosmic; 2546835
IARC_TP53; 1101
LiGeA; CCLE_109
Progenetix; CVCL_1287
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number44