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Cellosaurus HMV-II (CVCL_1282)

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Cell line name HMV-II
Synonyms HMV-2; HMVII; Human Melanoma Vagina-II
Accession CVCL_1282
Resource Identification Initiative To cite this cell line use: HMV-II (RRID:CVCL_1282)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Characteristics: Pigmented.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Vagina; UBERON=UBERON_0000996.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly469Val (c.1406G>T); ClinVar=VCV000044803; Zygosity=Heterozygous (Cosmic-CLP=907058; DepMap=ACH-002040).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (PubMed=12068308; PubMed=15467732; Cosmic-CLP=907058; DepMap=ACH-002040).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asn268Ile (c.803A>T); Zygosity=Heterozygous (Cosmic-CLP=907058; DepMap=ACH-002040).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.4
Native American0
East Asian, North76.31
East Asian, South21.9
South Asian0.25
European, North0.78
European, South0.36
Disease Vaginal melanoma (NCIt: C27394)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=907058; ECACC=92042701; PubMed=25877200; RCB=RCB0777; TKG=TKG 0318

Markers:
AmelogeninX
CSF1PO13
D3S135814,15
D5S81812
D7S8208,14
D8S117910
D13S31711
D16S53911
D18S5115
D21S1129
FGA23
Penta D11
Penta E5,21
TH016,9
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

CLPUB00585
Tsutomu Kasuga, Ichi Nojiri, Takeshi Furuse, Eiko Kubo, Yoriko Noda, Haruo Sugano, Goi Sakamoto;
Establishment of human melanoma cell like (HMV-II).
(In conference) Proceedings of the Japanese Cancer Association 35th annual meeting; pp.102-102; Japanese Cancer Association; Tokyo; Japan (1976)

PubMed=3361142; DOI=10.1111/1523-1747.ep12560926
Takuro Nakamura, Sachiko Seki, Osamu Matsubara, Shosuke Ito, Tsutomu Kasuga;
Specific incorporation of 4-S-cysteinylphenol into human melanoma cells.
J. Invest. Dermatol. 90:725-728(1988)

PubMed=2166075; DOI=10.1128/jcm.28.6.1147-1150.1990; PMCID=PMC267894
Hiroyuki Moriuchi, Takeko Oshima, Hidekazu Nishimura, Kiyoto Nakamura, Noriko Katsushima, Yoshio Numazaki;
Human malignant melanoma cell line (HMV-II) for isolation of influenza C and parainfluenza viruses.
J. Clin. Microbiol. 28:1147-1150(1990)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=15467732; DOI=10.1038/sj.onc.1208152
Hideaki Tanami, Issei Imoto, Akira Hirasawa, Yasuhiro Yuki, Itaru Sonoda, Jun Inoue, Kohichiroh Yasui, Akiko Misawa-Furihata, Yutaka Kawakami, Johji Inazawa;
Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.
Oncogene 23:8796-8804(2004)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) BCRJ; 0316
ECACC; 92042701
RCB; RCB0777
RCB; RCB3685
TKG; TKG 0318
Cell line databases/resources CLO; CLO_0003786
CLO; CLO_0050086
CLDB; cl1700
cancercelllines; CVCL_1282
Cell_Model_Passport; SIDM00291
CGH-DB; 9289-4
Cosmic-CLP; 907058
DepMap; ACH-002040
LINCS_LDP; LCL-1285
Anatomy/cell type resources BTO; BTO_0002918
Biological sample resources BioSample; SAMN03472908
Chemistry resources ChEMBL-Cells; CHEMBL3308667
ChEMBL-Targets; CHEMBL614826
GDSC; 907058
PharmacoDB; HMVII_555_2019
PubChem_Cell_line; CVCL_1282
Encyclopedic resources Wikidata; Q54889975
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM827367
GEO; GSM1669886
Polymorphism and mutation databases Cosmic; 688044
Cosmic; 874383
Cosmic; 905203
Cosmic; 907058
Cosmic; 1007155
Cosmic; 1477417
Cosmic; 2230117
IARC_TP53; 21375
Progenetix; CVCL_1282
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number42