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Cellosaurus HC-1 (CVCL_1243)

[Text version]
Cell line name HC-1
Synonyms HC1
Accession CVCL_1243
Resource Identification Initiative To cite this cell line use: HC-1 (RRID:CVCL_1243)
Comments Problematic cell line: Possibly misclassified. It is not certain that this cell line originate from a hairy cell leukemia (PubMed=22653958).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Population: Caucasian.
Doubling time: ~45 hours (DSMZ=ACC-301).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
HLA typing Source: DSMZCellDive=ACC-301
Class I
HLA-AA*03:01:01,03:01:01
HLA-BB*15:01:01,35:03:01
HLA-CC*03:04:01,03:04:01
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*04:01:01,04:01:01
HLA-DQDQA1*03:01:01,05:05:01
DQB1*03:01:01,03:02:01
HLA-DRDRA*01:01:01,01:01:01
DRB1*04:01:01,11:04:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North0.03
East Asian, South0
South Asian1.15
European, North70.39
European, South28.43
Disease Hairy cell leukemia (NCIt: C7402)
Classic hairy cell leukemia (ORDO: Orphanet_58017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=907044; DSMZ=ACC-301

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133820,25
D3S135815
D5S81811,12
D7S82010,12
D8S117912,13
D13S31711,12
D16S53910,11
D18S5112,15
D19S43314
D21S1130.2,33.2
FGA21,23
Penta D11
Penta E11,12
TH019,9.3
TPOX8
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=1851909
Joan H. Schiller, Gerard N. Bittner, Lorraine Faxon Meisner, Terry DeWayne Oberley, Diane Norback, Michael Schwabe, Connie R. Faltynek, Nancy Raab-Traub;
Establishment and characterization of an Epstein-Barr virus spontaneously transformed lymphocytic cell line derived from a hairy cell leukemia patient.
Leukemia 5:399-407(1991)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168
Cord C. Uphoff, Sabine A. Denkmann, Klaus G. Steube, Hans Gunther Drexler;
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010)

PubMed=22653958; DOI=10.1182/blood-2011-12-400374
Enrico Tiacci, Alessandra Pucciarini, Barbara Bigerna, Valentina Pettirossi, Francesca Strozzini, Maria Paola Martelli, Alessia Tabarrini, Hans Gunther Drexler, Brunangelo Falini;
Absence of BRAF-V600E in the human cell lines BONNA-12, ESKOL, HAIR-M, and HC-1 questions their origin from hairy cell leukemia.
Blood 119:5332-5333(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-301
Cell line databases/resources CLO; CLO_0003627
cancercelllines; CVCL_1243
Cell_Model_Passport; SIDM01073
Cosmic-CLP; 907044
DepMap; ACH-002242
DSMZCellDive; ACC-301
LINCS_LDP; LCL-1086
Biological sample resources BioSample; SAMN03473346
Chemistry resources ChEMBL-Cells; CHEMBL3308522
ChEMBL-Targets; CHEMBL2366299
GDSC; 907044
PharmacoDB; HC1_444_2019
PubChem_Cell_line; CVCL_1243
Encyclopedic resources Wikidata; Q54881463
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM1669840
Polymorphism and mutation databases Cosmic; 907044
Cosmic; 1809512
Cosmic; 2690009
IARC_TP53; 21358
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number35