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Cellosaurus GA-10 clone 4 (CVCL_1224)

[Text version]
Cell line name GA-10 clone 4
Synonyms GA-10 (Clone 4); GA-10-Clone-4
Accession CVCL_1224
Resource Identification Initiative To cite this cell line use: GA-10 clone 4 (RRID:CVCL_1224)
Comments Population: Caucasian.
Virology: EBV-negative.
Omics: Genomics; DNA methylation analysis.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro152Leu (c.455C>T); ClinVar=VCV000142766; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile232Asn (c.695T>A); ClinVar=VCV000850008; Zygosity=Heterozygous (from parent cell line).
Disease Adult Burkitt leukemia (NCIt: C7954)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1222 (GA-10)
Sex of cell Male
Age at sampling 41Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2393

Markers:
AmelogeninX,Y
CSF1PO10
D2S133820
D3S135818
D5S81811
D7S8208,10
D8S117911,13,14
D13S31711
D16S53911,12
D18S5114,18
D19S43312,14
D21S1128,30
FGA20,23
Penta D9,13
Penta E5,12
TH019,9.3
TPOX8,11
vWA16,20

Run an STR similarity search on this cell line
Publications

PubMed=11482875; DOI=10.1006/bcmd.2001.0428
Rapoport A.P., Simons-Evelyn M., Chen T., Sidell R., Luhowskyj S., Rosell K., Obrig T., Hicks D., Hinkle P.M., Nahm M., Insel R.A., Abboud C.N.
Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes.
Blood Cells Mol. Dis. 27:610-624(2001)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

Cross-references
Cell line collections (Providers) ATCC; CRL-2393
Cell line databases/resources CLO; CLO_0003441
cancercelllines; CVCL_1224
Cell_Model_Passport; SIDM01252
Chemistry resources PharmacoDB; GA10Clone4_396_2019
Encyclopedic resources Wikidata; Q54835417
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669802
Polymorphism and mutation databases Cosmic; 687841
Cosmic; 906867
IARC_TP53; 21336
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number30