Cellosaurus logo
expasy logo

Cellosaurus D283 Med (CVCL_1155)

[Text version]
Cell line name D283 Med
Synonyms D283 MED; D283-MED; D283_Med; D-283 Med; D-283 Med-C; D-283MED; D283MED; D283Med; D283-Med; D-283; D283; Med 283; H283
Accession CVCL_1155
Resource Identification Initiative To cite this cell line use: D283 Med (RRID:CVCL_1155)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; 2DE-MS.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Transcriptomics; Serial analysis of gene expression (SAGE).
Omics: Variations; SNP array analysis.
Misspelling: D283 MR; Note=Occasionally.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.87
Native American0
East Asian, North1.34
East Asian, South0
South Asian0
European, North63.61
European, South33.18
Disease Medulloblastoma, non-WNT/non-SHH, group 3 (NCIt: C129445)
Medulloblastoma (ORDO: Orphanet_616)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 6Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-185; CCRID=1101HUM-PUMC000341; Cosmic-CLP=906834

Markers:
AmelogeninX,Y
CSF1PO9,12
D2S133817,23
D3S135815
D5S81811
D7S82010
D8S117912,13
D13S3178,10
D16S53911
D18S5116,18
D19S43313,14
D21S1128,30.2
FGA20,23
Penta D9,13
Penta E7,10
TH017
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=4056828; DOI=10.1097/00005072-198511000-00005
Henry Seth Friedman, Peter C. Burger, Sandra H. Bigner, John Quinn Trojanowski, Carol J. Wikstrand, Edward Charles Halperin, Darell Doty Bigner;
Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med.
J. Neuropathol. Exp. Neurol. 44:592-605(1985)

PubMed=3103453; PMCID=PMC1899580
John Quinn Trojanowski, Henry Seth Friedman, Peter C. Burger, Darell Doty Bigner;
A rapidly dividing human medulloblastoma cell line (D283 MED) expresses all three neurofilament subunits.
Am. J. Pathol. 126:358-363(1987)

PubMed=2180567
Sandra H. Bigner, Henry Seth Friedman, Bert Vogelstein, W. Jerry Oakes, Darell Doty Bigner;
Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts.
Cancer Res. 50:2347-2350(1990)

PubMed=1822845
Carol J. Wikstrand, Henry Seth Friedman, Darell Doty Bigner;
Medulloblastoma cell-substrate interaction in vitro.
Invasion Metastasis 11:310-324(1991)

DOI=10.1007/0-306-46861-1_11
Francis Ali-Osman;
Brain tumors.
(In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.167-184; Kluwer Academic Publishers; New York; USA (1999)

PubMed=12973738; DOI=10.1002/pmic.200300460
Andreas Peyrl, Kurt Krapfenbauer, Irene Slavc, Jae-Won Yang, Thomas Strobel, Gert Lubec;
Protein profiles of medulloblastoma cell lines DAOY and D283: identification of tumor-related proteins and principles.
Proteomics 3:1781-1800(2003)

PubMed=16946619; DOI=10.1159/000095545
Poonam Dharmaraj, Stephen G. Ball, Helen Johnstone, Simon Bailey, Steven C. Clifford, Juliet Hale, Timothy D. Cheetham;
Hypercalcaemia in relapsed medulloblastoma 8 years post-diagnosis evidence to support PTHrP production by medulloblastoma cells.
Horm. Res. 66:268-272(2006)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20847082; DOI=10.1093/neuonc/noq091; PMCID=PMC3018940
Natalia Teider, Deborah K. Scott, Adrianne Neiss, Shyamal Dilhan Weeraratne, Vladimir M. Amani, Yi-Fei Wang, Victor E. Marquez, Yoon-Jae Cho, Scott L. Pomeroy;
Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.
Neuro-oncol. 12:1244-1256(2010)

PubMed=21177782; DOI=10.1093/neuonc/noq179; PMCID=PMC3064629
Shyamal Dilhan Weeraratne, Vladimir M. Amani, Adrianne Neiss, Natalia Teider, Deborah K. Scott, Scott L. Pomeroy, Yoon-Jae Cho;
miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma.
Neuro-oncol. 13:165-175(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24297863; DOI=10.1158/1078-0432.CCR-13-2281; PMCID=PMC4198154
Pratiti Bandopadhayay, Guillaume Bergthold, Brian Nguyen, Simone Schubert, Sharareh Gholamin, Yu-Jie Tang, Sara Bolin, Steven E. Schumacher, Rhamy Zeid, Sabran Masoud, Fu-Rong Yu ...Show all 25 authors... , Nujsaubnusi Vue, William James Gibson, Brenton R. Paolella, Siddhartha Shankar Mitra, Samuel H. Cheshier, Jun Qi, Kun-Wei Liu, Robert J. Wechsler-Reya, William Andrew Weiss, Fredrik Johansson Swartling, Mark W. Kieran, James E. Bradner, Rameen Beroukhim, Yoon-Jae Cho; Show fewer authors
BET bromodomain inhibition of MYC-amplified medulloblastoma.
Clin. Cancer Res. 20:912-925(2014)

PubMed=24300787; DOI=10.1158/1078-0432.CCR-13-2053; PMCID=PMC3962776
Anat Erdreich-Epstein, Nathan Robison, Xiu-Hai Ren, Hong Zhou, Jing-Ying Xu, Tom B. Davidson, Mathew Schur, Floyd Harry Gilles, Ling-Yun Ji, Jemily Malvar, Gregory M. Shackleford ...Show all 19 authors... , Ashley Sloane Margol, Mark D. Krieger, Alexander Russell Judkins, David T.W. Jones, Stefan Michael Pfister, Marcel Kool, Richard Sposto, Shahab Asgharzadeh; Show fewer authors
PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.
Clin. Cancer Res. 20:827-836(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028
Delyan P. Ivanov, Beth Coyle, David A. Walker, Anna M. Grabowska;
In vitro models of medulloblastoma: choosing the right tool for the job.
J. Biotechnol. 236:10-25(2016)

PubMed=27812533; DOI=10.1016/j.dib.2016.10.004; PMCID=PMC5079239
Delyan P. Ivanov, David A. Walker, Beth Coyle, Anna M. Grabowska;
Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
Data Brief 9:696-698(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31963405; DOI=10.3390/cancers12010226; PMCID=PMC7016648
Arianna Casciati, Mirella Tanori, Remi Manczak, Sofiane Saada, Barbara Tanno, Paola Giardullo, Elena Porcu, Elena Rampazzo, Luca Persano, Giampietro Viola, Claire Dalmay ...Show all 15 authors... , Fabrice Lalloue, Arnaud Pothier, Caterina Merla, Mariateresa Mancuso; Show fewer authors
Human medulloblastoma cell lines: investigating on cancer stem cell-like phenotype.
Cancers (Basel) 12:226.1-226.14(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; HTB-185
CLS; 300330
IZSLER; BS TCL 203
KCB; KCB 2010201YJ
Cell line databases/resources CLO; CLO_0002673
cancercelllines; CVCL_1155
CCRID; 1101HUM-PUMC000341
Cell_Model_Passport; SIDM00888
Cosmic-CLP; 906834
DepMap; ACH-000055
IGRhCellID; D283Med
LINCS_LDP; LCL-1577
Lonza; 654
Anatomy/cell type resources BTO; BTO_0005135
Biological sample resources BioSample; SAMN03472736
BioSample; SAMN10987924
CRISP screens repositories BioGRID_ORCS_Cell_line; 438
Chemistry resources ChEMBL-Cells; CHEMBL3307938
ChEMBL-Targets; CHEMBL614476
GDSC; 906834
PharmacoDB; D283MED_273_2019
PubChem_Cell_line; CVCL_1155
Encyclopedic resources Wikidata; Q54817202
Experimental variables resources EFO; EFO_0002156
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10838-111E1
GEO; GSM383762
GEO; GSM482336
GEO; GSM886969
GEO; GSM888038
GEO; GSM918116
GEO; GSM919357
GEO; GSM1234974
GEO; GSM1234975
GEO; GSM1669717
Polymorphism and mutation databases Cosmic; 687772
Cosmic; 906834
Cosmic; 923656
Cosmic; 973261
Cosmic; 974280
Cosmic; 975024
Cosmic; 1995381
Cosmic; 2362650
Cosmic; 2731179
IARC_TP53; 21296
LiGeA; CCLE_487
Progenetix; CVCL_1155
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number43