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Cellosaurus CTV-1 (CVCL_1150)

[Text version]
Cell line name CTV-1
Synonyms CTV1
Accession CVCL_1150
Resource Identification Initiative To cite this cell line use: CTV-1 (RRID:CVCL_1150)
Comments Problematic cell line: Probably misidentified. Originally thought to be a acute monoblastic leukemia but seems to be a T-ALL cell line (PubMed=15843827). Was also said to originate from a 40 year old female patient (PubMed=6593267) but has a male STR profile.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: ~36 hours (PubMed=6593267); ~40 hours (DSMZ=ACC-40).
Microsatellite instability: Instable (MSI-high) (PubMed=10739008; PubMed=31068700; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Misspelling: CTY-1; Cosmic=717685; PubMed=9379676.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Gly477Ser (c.1429G>A); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=753548; DepMap=ACH-002222).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=753548; DepMap=ACH-002222).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Gly831Glu (c.2492G>A); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=753548; DepMap=ACH-002222).
  • Mutation; HGNC; HGNC:6524; LCK; Simple; p.Ala353Val (c.1058C>T); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=753548; DepMap=ACH-002222).
  • Mutation; HGNC; HGNC:6524; LCK; Simple; p.Pro447Leu (c.1340C>T); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=753548; DepMap=ACH-002222).
  • Mutation; HGNC; HGNC:6524; LCK; Simple; p.Ala500Thr (c.1498G>A); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=753548; DepMap=ACH-002222).
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Gly1532Arg (c.4594G>A); ClinVar=VCV001462589; Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=753548; DepMap=ACH-002222).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Ser2523Ter (c.7568C>A); Zygosity=Heterozygous (Cosmic-CLP=753548; DepMap=ACH-002222).
  • Mutation; HGNC; HGNC:8804; PDGFRB; Simple; p.Met772Ile (c.2316G>A); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=753548; DepMap=ACH-002222).
  • Mutation; HGNC; HGNC:9967; RET; Simple; p.Cys656Phe (c.1967G>T); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=753548; DepMap=ACH-002222).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Arg75Met (c.224G>T); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=753548; DepMap=ACH-002222).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Lys175Met (c.524A>T); Zygosity=Heterozygous (PubMed=22675565; Cosmic-CLP=753548; DepMap=ACH-002222).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.02
Native American1.28
East Asian, North0
East Asian, South0.34
South Asian5.64
European, North45.18
European, South46.55
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_8150 (MOLT-15)
Originate from same individual CVCL_RX77 ! CTV-2
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=753548; DSMZ=ACC-40

Markers:
AmelogeninX,Y
CSF1PO9,12
D2S133817,18
D3S135815,17
D5S81812
D7S82011,13
D8S11799,15
D13S31711,12
D16S5399,14
D18S518,14
D19S43314,16
D21S1127,28
FGA24,25
Penta D9,11
Penta E6,13
TH019
TPOX8
vWA17,18 (DSMZ=ACC-40)
18,19 (Cosmic-CLP=753548)

Run an STR similarity search on this cell line
Publications

PubMed=6593267; DOI=10.20772/cancersci1959.75.8_660
Po-Min Chen, Chang-Fang Chiu, Tzeon-Jye Chiou, Sakan Maeda, Hung Chiang, Cheng-Hwai Tzeng, Taketoshi Sugiyama, Benjamin N. Chiang;
Establishment and characterization of a human monocytoid leukemia cell line, CTV-1.
Gann 75:660-664(1984)

PubMed=3458274
Hans Gunther Drexler, Gerhard Gaedicke, Sakan Maeda, Po-Min Chen, Jun Minowada;
Monocytoid leukemia cell line CTV-1: morphological, immunological and isoenzymatic characteristics.
Tumor Biol. 6:503-517(1986)

PubMed=9379676; DOI=10.1016/S0145-2126(97)00036-2
Xiao-Ming Sheng, Machiko Kawamura, Hiroaki Ohnishi, Kohmei Ida, Ryoji Hanada, Seiji Kojima, Miyuki Kobayashi, Fumio Bessho, Masayoshi Yanagisawa, Yasuhide Hayashi;
Mutations of the RAS genes in childhood acute myeloid leukemia, myelodysplastic syndrome and juvenile chronic myelocytic leukemia.
Leuk. Res. 21:697-701(1997)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Anna K. Hagstrom-Andersson, Patrik Eden, David Lindgren, Jens Nilsson, Carin Lassen, Jesper Heldrup, Magnus Fontes, Ake Borg, Felix Mitelman, Bertil Johansson, Mattias Hoglund, Thoas Fioretos;
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa, Jonathan Hinton, Ciara Fahey ...Show all 22 authors... , Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22675565; DOI=10.1371/journal.pone.0038463; PMCID=PMC3366948
Zeynep Kalender Atak, Kim De Keersmaecker, Valentina Gianfelici, Ellen Geerdens, Roel Vandepoel, Daphnie Pauwels, Michael Porcu, Idoya Lahortiga, Vanessa Brys, Wilhelm Gerhard Dirks, Hilmar Quentmeier, Jacqueline Cloos, Harry Cuppens ...Show all 17 authors... , Anne Uyttebroeck, Peter Vandenberghe, Jan Cools, Stein Aerts; Show fewer authors
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
PLoS ONE 7:e38463.1-e38463.11(2012)

PubMed=23955599; DOI=10.1038/ng.2731
Ayana Kon, Lee-Yung Shih, Masashi Minamino, Masashi Sanada, Yuichi Shiraishi, Yasunobu Nagata, Ken-ichi Yoshida, Yusuke Okuno, Masashige Bando, Ryuichiro Nakato, Shumpei Ishikawa, Aiko Sato-Otsubo, Genta Nagae ...Show all 41 authors... , Aiko Nishimoto, Claudia Haferlach, Daniel Nowak, Yusuke Sato, Tamara Alpermann, Masao Nagasaki, Teppei Shimamura, Hiroko Tanaka, Kenichi Chiba, Ryo Yamamoto, Tomoyuki Yamaguchi, Makoto Otsu, Naoshi Obara, Mamiko Sakata-Yanagimoto, Tsuyoshi Nakamaki, Ken Ishiyama, Florian Nolte, Wolf-Karsten Hofmann, Shuichi Miyawaki, Shigeru Chiba, Hiraku Mori, Hiromitsu Nakauchi, Harold Phillip Koeffler, Hiroyuki Aburatani, Torsten Haferlach, Katsuhiko Shirahige, Satoru Miyano, Seishi Ogawa; Show fewer authors
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer, Patricia Greninger, Ewald van Dyk ...Show all 39 authors... , Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu, Alexander Y. Andreev-Drakhlin, Jaegil Kim ...Show all 68 authors... , Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker, Jennifer Koh, Howard Lightfoot ...Show all 32 authors... , Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-40
Cell line databases/resources CLO; CLO_0002638
CLDB; cl927
cancercelllines; CVCL_1150
Cell_Model_Passport; SIDM00951
Cosmic-CLP; 753548
DepMap; ACH-001737
DepMap; ACH-002222
DSMZCellDive; ACC-40
LINCS_LDP; LCL-1013
Biological sample resources BioSample; SAMN03473579
Chemistry resources ChEMBL-Cells; CHEMBL3308189
ChEMBL-Targets; CHEMBL2366360
GDSC; 753548
PharmacoDB; CTV1_268_2019
PubChem_Cell_line; CVCL_1150
Encyclopedic resources Wikidata; Q54814774
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1374458
GEO; GSM1669712
Polymorphism and mutation databases Cosmic; 717685
Cosmic; 753548
Cosmic; 787426
Cosmic; 947372
Cosmic; 975244
Cosmic; 998755
Cosmic; 1078737
Cosmic; 1151776
Cosmic; 1524794
Cosmic; 1760520
Cosmic; 2089657
Cosmic; 2131536
Cosmic; 2306203
IARC_TP53; 21259
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number41