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Cellosaurus CRO-AP5 (CVCL_1148)

[Text version]
Cell line name CRO-AP5
Synonyms CRO-AP/5; CROAP5; AP5
Accession CVCL_1148
Resource Identification Initiative To cite this cell line use: CRO-AP5 (RRID:CVCL_1148)
Comments Part of: LL-100 blood cancer cell line panel.
Virology: Contains 30 to 60 copies of the human herpesvirus 8 (HHV-8/KSHV) genome per cell.
Doubling time: ~35-40 hours (DSMZ=ACC-215).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Transformant: NCBI_TaxID; 37296; Human herpesvirus 8 (HHV-8/KSHV).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
HLA typing Source: DSMZCellDive=ACC-215
Class I
HLA-AA*24:02:01,30:01:01
HLA-BB*13:02:01,15:18:01
HLA-CC*06:02:01,07:04:01
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*04:01:01,16:01:01
HLA-DQDQA1*02:01:01,02:01:01
DQB1*02:02:01,03:01:01
HLA-DRDRA*01:01:01,01:01:01
DRB1*07:01:01,11:01:01
Disease Primary effusion lymphoma (NCIt: C6915)
Primary effusion lymphoma (ORDO: Orphanet_48686)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-215

Markers:
AmelogeninX
CSF1PO12
D2S133817,18
D3S135817,18
D5S81812,13
D7S82010,12
D8S117912
D13S31711,13
D16S53911
D18S5110,18
D19S43314
D21S1129,32.2
FGA25
Penta D11,12
Penta E7,11
TH016,7
TPOX8,11
vWA16

Run an STR similarity search on this cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=CRO-AP%2f5
Publications

PubMed=9734661; DOI=10.1046/j.1365-2141.1998.00877.x
Antonino Carbone, Anna M. Cilia, Annunziata Gloghini, Daniela Capello, Michela Todesco, Silvia Quattrone, Rachele Volpe, Gianluca Gaidano;
Establishment and characterization of EBV-positive and EBV-negative primary effusion lymphoma cell lines harbouring human herpesvirus type-8.
Br. J. Haematol. 102:1081-1089(1998)

PubMed=9766492; DOI=10.1038/sj.leu.2401160
Hans Gunther Drexler, Cord C. Uphoff, Gianluca Gaidano, Antonino Carbone;
Lymphoma cell lines: in vitro models for the study of HHV-8+ primary effusion lymphomas (body cavity-based lymphomas).
Leukemia 12:1507-1517(1998)

PubMed=10784388; DOI=10.3109/10428190009148391
Antonino Carbone, Anna M. Cilia, Annunziata Gloghini, Daniela Capello, Tiziana Perin, Daniela Bontempo, Vincenzo Canzonieri, Umberto Tirelli, Rachele Volpe, Gianluca Gaidano;
Primary effusion lymphoma cell lines harbouring human herpesvirus type-8.
Leuk. Lymphoma 36:447-456(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168
Cord C. Uphoff, Sabine A. Denkmann, Klaus G. Steube, Hans Gunther Drexler;
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010)

PubMed=21685375; DOI=10.1182/blood-2010-12-323659; PMCID=PMC3158728
Debasmita Roy, Sang-Hoon Sin, Blossom Damania, Dirk P. Dittmer;
Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.
Blood 118:e32-e39(2011)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-215
Cell line databases/resources CLO; CLO_0002619
CLDB; cl420
cancercelllines; CVCL_1148
DSMZCellDive; ACC-215
IGRhCellID; CROAP5
Anatomy/cell type resources BTO; BTO_0002726
Biological sample resources BioSample; SAMN03473377
Encyclopedic resources Wikidata; Q54814509
Experimental variables resources EFO; EFO_0002146
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM634730
Polymorphism and mutation databases Cosmic; 906806
IARC_TP53; 21258
Progenetix; CVCL_1148
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number32