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Cellosaurus CRO-AP2 (CVCL_1147)

[Text version]
Cell line name CRO-AP2
Synonyms CRO-AP/2; CROAP2; AP2
Accession CVCL_1147
Resource Identification Initiative To cite this cell line use: CRO-AP2 (RRID:CVCL_1147)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Population: Caucasian.
Doubling time: ~20-40 hours (DSMZ=ACC-48).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Transformant: NCBI_TaxID; 37296; Human herpesvirus 8 (HHV-8/KSHV).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
HLA typing Source: DSMZCellDive=ACC-48
Class I
HLA-AA*68:02:01,68:02:01
HLA-BB*15:01:01,15:01:01
HLA-CC*03:03:01,07:04:01
Class II
HLA-DPDPA1*01:03:01,02:01:01
DPB1*03:01:01,10:01:01
HLA-DQDQA1*03:01:01,03:01:01
DQB1*03:02:01,05:01:01
HLA-DRDRA*01:01:01,01:02:02
DRB1*04:02:01,14:54:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.25
Native American0.15
East Asian, North0.73
East Asian, South0.29
South Asian5.13
European, North44.53
European, South48.9
Disease Primary effusion lymphoma (NCIt: C6915)
Primary effusion lymphoma (ORDO: Orphanet_48686)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 49Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=906807; DSMZ=ACC-48

Markers:
AmelogeninX
CSF1PO11,12
D2S133818,23
D3S135816
D5S81812
D7S82010,11
D8S117913,14
D13S31711
D16S53911
D18S5112,14
D19S43314
D21S1129,31.2
FGA20,23
Penta D10,13
Penta E12
TH016,8
TPOX10,11
vWA17,18

Run an STR similarity search on this cell line
Web pages Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=CRO-AP%2f2
Publications

PubMed=9389573; DOI=10.1002/(SICI)1097-0215(19971114)73:4<562::AID-IJC18>3.0.CO;2-B
Antonino Carbone, Anna M. Cilia, Annunziata Gloghini, Vincenzo Canzonieri, Cristina Pastore, Michela Todesco, Marzia Cozzi, Tiziana Perin, Rachele Volpe, Antonio Pinto, Gianluca Gaidano;
Establishment of HHV-8-positive and HHV-8-negative lymphoma cell lines from primary lymphomatous effusions.
Int. J. Cancer 73:562-569(1997)

PubMed=9766492; DOI=10.1038/sj.leu.2401160
Hans Gunther Drexler, Cord C. Uphoff, Gianluca Gaidano, Antonino Carbone;
Lymphoma cell lines: in vitro models for the study of HHV-8+ primary effusion lymphomas (body cavity-based lymphomas).
Leukemia 12:1507-1517(1998)

PubMed=10784388; DOI=10.3109/10428190009148391
Antonino Carbone, Anna M. Cilia, Annunziata Gloghini, Daniela Capello, Tiziana Perin, Daniela Bontempo, Vincenzo Canzonieri, Umberto Tirelli, Rachele Volpe, Gianluca Gaidano;
Primary effusion lymphoma cell lines harbouring human herpesvirus type-8.
Leuk. Lymphoma 36:447-456(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168
Cord C. Uphoff, Sabine A. Denkmann, Klaus G. Steube, Hans Gunther Drexler;
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010)

PubMed=21685375; DOI=10.1182/blood-2010-12-323659; PMCID=PMC3158728
Debasmita Roy, Sang-Hoon Sin, Blossom Damania, Dirk P. Dittmer;
Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.
Blood 118:e32-e39(2011)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-48
Cell line databases/resources CLO; CLO_0002617
CLDB; cl3486
cancercelllines; CVCL_1147
Cell_Model_Passport; SIDM00952
Cosmic-CLP; 906807
DepMap; ACH-002220
DSMZCellDive; ACC-48
IGRhCellID; CROAP2
Anatomy/cell type resources BTO; BTO_0002724
Biological sample resources BioSample; SAMN03473560
Chemistry resources ChEMBL-Cells; CHEMBL3308254
ChEMBL-Targets; CHEMBL2366080
GDSC; 906807
PharmacoDB; CROAP2_264_2019
PubChem_Cell_line; CVCL_1147
Encyclopedic resources Wikidata; Q54814506
Experimental variables resources EFO; EFO_0002145
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM634729
GEO; GSM1669709
Polymorphism and mutation databases Cosmic; 906807
IARC_TP53; 21257
Progenetix; CVCL_1147
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number39