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Cellosaurus CP50-MEL-B (CVCL_1143)

[Text version]
Cell line name CP50-MEL-B
Synonyms CP50MELB; CP50-MEL
Accession CVCL_1143
Resource Identification Initiative To cite this cell line use: CP50-MEL-B (RRID:CVCL_1143)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (DepMap=ACH-002096).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Tyr44fs*76 (c.128_129insT); Zygosity=Unspecified (DepMap=ACH-002096).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Pro246fs*11 (c.736_737insAA); Zygosity=Unspecified (DepMap=ACH-002096).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.34
East Asian, North0
East Asian, South2.1
South Asian3.16
European, North59.29
European, South35.11
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_UY79 ! CP50-EBV
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=753545

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81812
D7S8208,11
D13S31712
D16S53912,14
TH018,9.3
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa, Jonathan Hinton, Ciara Fahey ...Show all 22 authors... , Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20364150; DOI=10.1038/ni.1862
Nicolas Parmentier, Vincent Stroobant, Didier Colau, Philippe de Diesbach, Sandra Morel, Jacques Chapiro, Peter M. van Endert, Benoit J. van den Eynde;
Production of an antigenic peptide by insulin-degrading enzyme.
Nat. Immunol. 11:449-454(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer, Patricia Greninger, Ewald van Dyk ...Show all 39 authors... , Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker, Jennifer Koh, Howard Lightfoot ...Show all 32 authors... , Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resources CLO; CLO_0037124
cancercelllines; CVCL_1143
Cell_Model_Passport; SIDM00175
Cosmic-CLP; 753545
DepMap; ACH-002096
LINCS_LDP; LCL-1270
Chemistry resources ChEMBL-Cells; CHEMBL3308325
ChEMBL-Targets; CHEMBL2366076
GDSC; 753545
PharmacoDB; CP50MELB_260_2019
PubChem_Cell_line; CVCL_1143
Encyclopedic resources Wikidata; Q54814369
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669705
Polymorphism and mutation databases Cosmic; 753545
IARC_TP53; 21254
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number33