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Cellosaurus CP50-MEL-B (CVCL_1143)

[Text version]

Cell line name CP50-MEL-B
Synonyms CP50MELB; CP50-MEL
Accession CVCL_1143
Resource Identification Initiative To cite this cell line use: CP50-MEL-B (RRID:CVCL_1143)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (DepMap).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Tyr44fs*76 (c.128_129insT); Zygosity=Unspecified (DepMap).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Pro246fs*11 (c.736_737insAA); Zygosity=Unspecified (DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.34
East Asian, North0
East Asian, South2.1
South Asian3.16
European, North59.29
European, South35.11
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_UY79 ! CP50-EBV
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81812
D7S8208,11
D13S31712
D16S53912,14
TH018,9.3
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=20164919; DOI=10.1038/nature08768
Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20364150; DOI=10.1038/ni.1862
Parmentier N., Stroobant V., Colau D., de Diesbach P., Morel S., Chapiro J., van Endert P., van den Eynde B.J.
Production of an antigenic peptide by insulin-degrading enzyme.
Nat. Immunol. 11:449-454(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line databases/resources Cell_Model_Passport; SIDM00175
Cosmic-CLP; 753545
DepMap; ACH-002096
LINCS_LDP; LCL-1270
Chemistry resources ChEMBL-Cells; CHEMBL3308325
ChEMBL-Targets; CHEMBL2366076
GDSC; 753545
PharmacoDB; CP50MELB_260_2019
PubChem_Cell_line; CVCL_1143
Encyclopedic resources Wikidata; Q54814369
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669705
Polymorphism and mutation databases Cosmic; 753545
IARC_TP53; 21254
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update15-Dec-2022
Version number27