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Cellosaurus CHP-134 (CVCL_1124)

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Cell line name CHP-134
Synonyms CHP 134; CHP_134; CHP134; Children's Hospital of Philadelphia-134
Accession CVCL_1124
Resource Identification Initiative To cite this cell line use: CHP-134 (RRID:CVCL_1124)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: 57.6 hours (PubMed=10079); ~30 hours (DSMZ=ACC-653).
Karyotypic information: Pseudodiploid (PubMed=71759).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Adrenal gland; UBERON=UBERON_0002369.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.04
Native American0
East Asian, North0.15
East Asian, South0
South Asian0.93
European, North70.26
European, South28.62
Disease Adrenal gland neuroblastoma (NCIt: C4827)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 1Y1M
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=910941; DepMap=ACH-001338; DSMZ=ACC-653; ECACC=06122002; RCB=RCB0487

Markers:
AmelogeninX,Y
CSF1PO9,12 (Cosmic-CLP=910941; RCB=RCB0487)
9,13 (DepMap=ACH-001338; DSMZ=ACC-653; ECACC=06122002)
D2S133820,27
D3S135816
D5S81811,12
D7S8209
D8S11798,14 (DepMap=ACH-001338)
14 (DSMZ=ACC-653)
D13S3178,10,11 (DepMap=ACH-001338)
8,11 (Cosmic-CLP=910941; DSMZ=ACC-653; ECACC=06122002; RCB=RCB0487)
D16S53911 (RCB=RCB0487)
11,13 (Cosmic-CLP=910941; DepMap=ACH-001338; DSMZ=ACC-653; ECACC=06122002)
D18S5115,18
D19S43312,13
D21S1128,29
FGA21,25
Penta D9
Penta E5,7
TH019,9.3
TPOX8
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=10079
Harvey R. Schlesinger, James M. Gerson, Paul Sidney Moorhead, Henry Maguire, Klaus Hummeler;
Establishment and characterization of human neuroblastoma cell lines.
Cancer Res. 36:3094-3100(1976)

PubMed=71759; DOI=10.1126/science.71759
Gloria Brady Balaban-Malenbaum, Fred Gilbert;
Double minute chromosomes and the homogeneously staining regions in chromosomes of a human neuroblastoma cell line.
Science 198:739-741(1977)

PubMed=6113887
Harvey R. Schlesinger, Lucy Balian Rorke-Adams, R. Jamieson, Klaus Hummeler;
Neuronal properties of neuroectodermal tumors in vitro.
Cancer Res. 41:2573-2575(1981)

PubMed=7139592; DOI=10.1016/0165-4608(82)90105-4
Fred Gilbert, Gloria Brady Balaban-Malenbaum, Paul Sidney Moorhead, Diana W. Bianchi, Harvey R. Schlesinger;
Abnormalities of chromosome 1p in human neuroblastoma tumors and cell lines.
Cancer Genet. Cytogenet. 7:33-42(1982)

DOI=10.1016/B978-0-12-008304-6.50015-4
June Lee Biedler, Marian B. Meyers, Barbara A. Spengler;
Homogeneously staining regions and double minute chromosomes, prevalent cytogenetic abnormalities of human neuroblastoma cells.
(In book chapter) Advances in cellular neurobiology, Vol. 4; Fedoroff, Sergey & Hertz, Leif (eds.); pp.267-307; Academic Press; New York; USA (1983)

PubMed=6888561; DOI=10.1038/305245a0
Manfred Schwab, Kari Alitalo, Karl-Heinz Klempnauer, Harold Eliot Varmus, John Michael Bishop, Fred Gilbert, Garrett M. Brodeur, Milton N. Goldstein, Jeffrey M. Trent;
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.
Nature 305:245-248(1983)

DOI=10.1007/0-306-46872-7_2
Carol Jeanne Thiele;
Neuroblastoma.
(In book chapter) Human cell culture. Vol. 1. Cancer cell lines part 1; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.21-53; Kluwer Academic Publishers; New York; USA (1999)

PubMed=12702577
Fumiko Saito-Ohara, Issei Imoto, Jun Inoue, Hajime Hosoi, Akira Nakagawara, Tohru Sugimoto, Johji Inazawa;
PPM1D is a potential target for 17q gain in neuroblastoma.
Cancer Res. 63:1876-1883(2003)

PubMed=15892104; DOI=10.1002/gcc.20198
Yael P. Mosse, Joel Greshock, Adam A. Margolin, Tara Naylor, Kristina A. Cole, Deepa Khazi, George Hii, Cynthia Winter, Syed Shahzad, Muhammad Usman Asziz, Jaclyn A. Biegel ...Show all 13 authors... , Barbara L. Weber, John Matthew Maris; Show fewer authors
High-resolution detection and mapping of genomic DNA alterations in neuroblastoma.
Genes Chromosomes Cancer 43:390-403(2005)

PubMed=16822308; DOI=10.1186/1471-2407-6-177; PMCID=PMC1533846
Vincent Dam, Brian T. Morgan, Pavel Mazanek, Michael D. Hogarty;
Mutations in PIK3CA are infrequent in neuroblastoma.
BMC Cancer 6:177.1-177.10(2006)

PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043
Yael P. Mosse, Marci Laudenslager, Luca Longo, Kristina A. Cole, Andrew Wood, Edward Fathi Attiyeh, Michael J. Laquaglia, Rachel Sennett, Jill E. Lynch, Patrizia Perri, Genevieve Laureys ...Show all 22 authors... , Frank Speleman, Cecilia Kim, Cui-Ping Hou, Hakon Hakonarson, Ali Torkamani, Nicholas J. Schork, Garrett M. Brodeur, Gian Paolo Tonini, Eric Rappaport, Marcella Devoto, John Matthew Maris; Show fewer authors
Identification of ALK as a major familial neuroblastoma predisposition gene.
Nature 455:930-935(2008)

PubMed=18923524; DOI=10.1038/nature07399
Yu-Yan Chen, Junko Takita, Young Lim Choi, Motohiro Kato, Miki Ohira, Masashi Sanada, Li-Li Wang, Manabu Soda, Akira Kikuchi, Takashi Igarashi, Akira Nakagawara ...Show all 14 authors... , Yasuhide Hayashi, Hiroyuki Mano, Seishi Ogawa; Show fewer authors
Oncogenic mutations of ALK kinase in neuroblastoma.
Nature 455:971-974(2008)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=22213050; DOI=10.1002/ijc.27415; PMCID=PMC3757132
Joanna E. Gawecka, Dirk Geerts, Jan Koster, Maisel J. Caliva, Florian J. Sulzmaier, John Opoku-Ansah, Randal K. Wada, Andre S. Bachmann, Joe W. Ramos;
PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma.
Int. J. Cancer 131:1556-1568(2012)

PubMed=23202128; DOI=10.1038/ng.2493; PMCID=PMC3557959
Mark Sausen, Rebecca J. Leary, Sian Jones, Jian Wu, Charles Patrick Reynolds, Xue-Yuan Liu, Amanda L. Blackford, Giovanni Parmigiani, Luis Alberto Diaz Jr., Nickolas Papadopoulos, Bert Vogelstein ...Show all 14 authors... , Kenneth Wayne Kinzler, Victor E. Velculescu, Michael D. Hogarty; Show fewer authors
Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.
Nat. Genet. 45:12-17(2013)

PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703
Nadine Loschmann, Martin Michaelis, Florian Rothweiler, Richard Zehner, Jaroslaw Cinatl, Yvonne Voges, Mohsen Sharifi, Kristoffer Riecken, Jochen Meyer, Andreas von Deimling, Iduna Fichtner ...Show all 14 authors... , Taravat Ghafourian, Frank Westermann, Jindrich Cinatl Jr.; Show fewer authors
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315
Jo Lynne Harenza, Maura A. Diamond, Rebecca N. Adams, Michael M. Song, Heather L. Davidson, Lori S. Hart, Maiah H. Dent, Paolo Fortina, Charles Patrick Reynolds, John Matthew Maris;
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033.1-170033.8(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-653
ECACC; 06122002
RCB; RCB0487
Cell line databases/resources CLO; CLO_0051417
cancercelllines; CVCL_1124
Cell_Model_Passport; SIDM00285
CGH-DB; 75-1
CGH-DB; 9099-4
Cosmic-CLP; 910941
DepMap; ACH-001338
DSMZCellDive; ACC-653
Anatomy/cell type resources BTO; BTO_0002989
Biological sample resources BioSample; SAMN03472330
BioSample; SAMN03473466
Chemistry resources ChEMBL-Cells; CHEMBL3308253
ChEMBL-Targets; CHEMBL2366128
GDSC; 910941
PharmacoDB; CHP134_199_2019
PubChem_Cell_line; CVCL_1124
Encyclopedic resources Wikidata; Q54813265
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10508-107D4
GEO; GSM313800
GEO; GSM333795
GEO; GSM563356
GEO; GSM692863
GEO; GSM1366404
GEO; GSM1669677
GEO; GSM2371222
GEO; GSM2394376
GEO; GSM3145587
GEO; GSM3145699
Polymorphism and mutation databases Cosmic; 688063
Cosmic; 801744
Cosmic; 848934
Cosmic; 910941
Cosmic; 920253
Cosmic; 930063
Cosmic; 947707
Cosmic; 1019934
Cosmic; 1037353
Cosmic; 1099150
Cosmic; 1109362
Cosmic; 1153779
Cosmic; 1161986
Cosmic; 1526620
Cosmic; 2131592
Cosmic; 2393629
Cosmic; 2485943
IARC_TP53; 21226
Progenetix; CVCL_1124
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number41