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Cellosaurus CAL-39 (CVCL_1109)

[Text version]
Cell line name CAL-39
Synonyms CAL 39; CAL39; Centre Antoine Lacassagne-39
Accession CVCL_1109
Resource Identification Initiative To cite this cell line use: CAL-39 (RRID:CVCL_1109)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: 30 hours (Note=At 34th passage) (PubMed=21573363); ~50-70 hours (DSMZ=ACC-187).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Vulva; UBERON=UBERON_0000997.
Sequence variations
  • Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Arg2597Ter (c.7789C>T); ClinVar=VCV001937208; Zygosity=Homozygous (Cosmic-CLP=924107; DepMap=ACH-002091).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro151His (c.452C>A); ClinVar=VCV000376639; Zygosity=Homozygous (Cosmic-CLP=924107; DepMap=ACH-002091).
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.88
Native American0.78
East Asian, North0
East Asian, South1.64
South Asian9.08
European, North26.43
European, South59.19
Disease Vulvar squamous cell carcinoma (NCIt: C4052)
Vulvar squamous cell carcinoma (ORDO: Orphanet_494448)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 76Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=924107; DSMZ=ACC-187

Markers:
AmelogeninX
CSF1PO12
D2S133821
D3S135817
D5S81812
D7S8208
D8S117916
D13S31712,13
D16S5399,11
D18S5116,17
D19S43313
D21S1130
FGA21
Penta D12,13
Penta E7,12
TH016,7
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=21573363; DOI=10.3892/ijo.3.2.293
Jeannine Gioanni, Josiane Grosgeorge, Evelyne Zanghellini, Christiane Mazeau, Patrick Gaudray, Francette Ettore, Patricia Formento, Francois Demard;
Characterization of CAL39, a new human cell-line derived from a vulvar squamous-cell carcinoma.
Int. J. Oncol. 3:293-297(1993)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) DSMZ; ACC-187
Cell line databases/resources CLO; CLO_0002184
CLDB; cl630
cancercelllines; CVCL_1109
Cell_Model_Passport; SIDM00935
Cosmic-CLP; 924107
DepMap; ACH-002091
DSMZCellDive; ACC-187
LINCS_LDP; LCL-1294
Biological sample resources BioSample; SAMN03473368
Chemistry resources ChEMBL-Cells; CHEMBL3308716
ChEMBL-Targets; CHEMBL1075410
GDSC; 924107
PharmacoDB; CAL39_171_2019
PubChem_Cell_line; CVCL_1109
Encyclopedic resources Wikidata; Q54808399
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
GEO; GSM1669651
Polymorphism and mutation databases Cosmic; 924107
Cosmic; 1995358
IARC_TP53; 27146
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number39