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Cellosaurus BC-3 (CVCL_1080)

[Text version]
Cell line name BC-3
Synonyms BC3
Accession CVCL_1080
Resource Identification Initiative To cite this cell line use: BC-3 (RRID:CVCL_1080)
Comments Group: Patented cell line.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-2277.
Population: Caucasian.
Doubling time: ~50-60 hours (DSMZ=ACC-679).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 37296; Human herpesvirus 8 (HHV-8/KSHV).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
HLA typing Source: DSMZCellDive=ACC-679
Class I
HLA-AA*02:05:01,03:01:01
HLA-BB*14:02:01,50:01:01
HLA-CC*06:02:01,08:02:01
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*04:01:01,104:01
HLA-DQDQA1*02:01:01,01:01:02
DQB1*02:02:01,05:01:01
HLA-DRDRA*01:01:01,01:01:01
DRB1*01:02:01,07:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African7.13
Native American1.02
East Asian, North6.58
East Asian, South0
South Asian6.31
European, North25.3
European, South53.67
Disease Primary effusion lymphoma (NCIt: C6915)
Primary effusion lymphoma (ORDO: Orphanet_48686)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_4J72 ! KS-1 [Human primary effusion lymphoma]
Sex of cell Male
Age at sampling 85Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3615; Cosmic-CLP=910918; DSMZ=ACC-679

Markers:
AmelogeninX
CSF1PO11,12
D2S133824,25
D3S135815,17
D5S81811,12
D7S82010,12
D8S117914,16
D13S31711
D16S53912
D18S5114,21.2
D19S43314,15
D21S1129,30
FGA18,22
Penta D8,13
Penta E7,15
TH016,9
TPOX8,11
vWA14,18

Run an STR similarity search on this cell line
Web pages Provider; Cornell TTO; -; https://cornell.flintbox.com/technologies/d21d6b39-b480-4ad4-8785-cc7a70c91788
Publications

PubMed=8839859; DOI=10.1182/blood.V88.7.2648.bloodjournal8872648
Leandros Arvanitakis, Enrique A. Mesri, Roland Gela Nador, Jonathan William Said, Adam S. Asch, Daniel M. Knowles, Ethel Cesarman;
Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus.
Blood 88:2648-2654(1996)

PubMed=9766492; DOI=10.1038/sj.leu.2401160
Hans Gunther Drexler, Cord C. Uphoff, Gianluca Gaidano, Antonino Carbone;
Lymphoma cell lines: in vitro models for the study of HHV-8+ primary effusion lymphomas (body cavity-based lymphomas).
Leukemia 12:1507-1517(1998)

Patent=US5908773
Ethel Cesarman, Leandros Arvanitakis, Daniel M. Knowles, Enrique A. Mesri;
KSHV positive cell lines.
Patent number US5908773, 01-Jun-1999

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=15613351; DOI=10.1128/JVI.79.2.1244-1251.2005; PMCID=PMC538532
Wen Fan, Darya Bubman, Amy Chadburn, William J. Harrington Jr., Ethel Cesarman, Daniel M. Knowles;
Distinct subsets of primary effusion lymphoma can be identified based on their cellular gene expression profile and viral association.
J. Virol. 79:1244-1251(2005)

PubMed=17121789; DOI=10.1128/JVI.01757-06; PMCID=PMC1797584
Christin E. Burd, Sang-Hoon Sin, Dirk P. Dittmer;
Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy.
J. Virol. 81:1912-1922(2007)

PubMed=19608668; DOI=10.3324/haematol.2009.007260; PMCID=PMC2719041
Emmanuelle Boulanger, Agnes Marchio, Saw-See Hong, Pascal Pineau;
Mutational analysis of TP53, PTEN, PIK3CA and CTNNB1/beta-catenin genes in human herpesvirus 8-associated primary effusion lymphoma.
Haematologica 94:1170-1174(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21685375; DOI=10.1182/blood-2010-12-323659; PMCID=PMC3158728
Debasmita Roy, Sang-Hoon Sin, Blossom Damania, Dirk P. Dittmer;
Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.
Blood 118:e32-e39(2011)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Hilmar Quentmeier, Claudia Pommerenke, Wilhelm Gerhard Dirks, Sonja Eberth, Max Koeppel, Roderick A.F. MacLeod, Stefan Nagel, Klaus G. Steube, Cord C. Uphoff, Hans Gunther Drexler;
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218.1-8218.14(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-2277 - Discontinued
ATCC; CRL-3615
CCTCC; GDC0221
DSMZ; ACC-679
Cell line databases/resources CLO; CLO_0001891
cancercelllines; CVCL_1080
CCRID; 3101HUMSCSP5016
Cell_Model_Passport; SIDM00895
Cosmic-CLP; 910918
DepMap; ACH-002215
DSMZCellDive; ACC-679
IGRhCellID; BC3
LINCS_LDP; LCL-1948
Anatomy/cell type resources BTO; BTO_0002722
Biological sample resources BioSample; SAMN03472835
BioSamples; SAMEA365848
BioSamples; SAMEA365859
CRISP screens repositories BioGRID_ORCS_Cell_line; 1098
Chemistry resources ChEMBL-Cells; CHEMBL3308890
ChEMBL-Targets; CHEMBL2366371
GDSC; 910918
PharmacoDB; BC3_79_2019
PubChem_Cell_line; CVCL_1080
Encyclopedic resources Wikidata; Q54795189
Experimental variables resources EFO; EFO_0002046
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM33135
GEO; GSM38796
GEO; GSM38797
GEO; GSM634733
GEO; GSM710419
GEO; GSM710435
GEO; GSM1669611
GEO; GSM3150237
Polymorphism and mutation databases Cosmic; 687836
Cosmic; 910918
Cosmic; 1238077
Cosmic; 1515188
Cosmic; 1588558
IARC_TP53; 21190
IARC_TP53; 26979
Progenetix; CVCL_1080
Proteomic databases PRIDE; PXD012087
PRIDE; PXD030304
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number41