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Cellosaurus ATN-1 (CVCL_1073)

[Text version]
Cell line name ATN-1
Synonyms ATN1
Accession CVCL_1073
Resource Identification Initiative To cite this cell line use: ATN-1 (RRID:CVCL_1073)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: ~24 hours (PubMed=3260813).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val272Leu (c.814G>C); ClinVar=VCV000574679; Zygosity=Homozygous (Cosmic-CLP=910687; DepMap=ACH-002058).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.05
East Asian, North78.58
East Asian, South17.98
South Asian1.43
European, North0
European, South1.95
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 47Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=910687; RCB=RCB1440

Markers:
AmelogeninX,Y
CSF1PO9,11
D5S81810,13
D7S8208
D13S31711,12
D16S53911
TH019
TPOX9
vWA14,18

Run an STR similarity search on this cell line
Publications

PubMed=3260813; DOI=10.1016/0165-4608(88)90171-9
Tomoki Naoe, Yukihiro Akao, Kazumasa Yamada, Kazuhiko R. Utsumi, Koichi Koike, Michihiro Shamoto, Katsuo Koie, Yoshikazu Kurosawa, Koji Kato, Masafumi Abe, Hiroshi Shiku;
Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells.
Cancer Genet. Cytogenet. 34:77-88(1988)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886
Jun Takizawa, Ritsuro Suzuki, Hiroyuki Kuroda, Atae Utsunomiya, Yoshitoyo Kagami, Tatsuroh Joh, Yoshifusa Aizawa, Ryuzo Ueda, Masao Seto;
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) RCB; RCB1440
Cell line databases/resources CLO; CLO_0050985
cancercelllines; CVCL_1073
Cell_Model_Passport; SIDM00233
Cosmic-CLP; 910687
DepMap; ACH-002058
LINCS_LDP; LCL-1025
Biological sample resources BioSample; SAMN03472143
Chemistry resources ChEMBL-Cells; CHEMBL3308183
ChEMBL-Targets; CHEMBL2366277
GDSC; 910687
PharmacoDB; ATN1_68_2019
PubChem_Cell_line; CVCL_1073
Encyclopedic resources Wikidata; Q54751288
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10421-106C7
GEO; GSM1669604
Polymorphism and mutation databases Cosmic; 910687
IARC_TP53; 21177
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number39