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Cellosaurus 647V (CVCL_1049)

[Text version]
Cell line name 647V
Synonyms 647-V; 647 V
Accession CVCL_1049
Resource Identification Initiative To cite this cell line use: 647V (RRID:CVCL_1049)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: 32 hours (PubMed=66978; PubMed=748774); ~30 hours (DSMZ=ACC-414).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Misspelling: 647B; PubMed=748774.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; HGNC:3373; EP300; Simple; p.Gln993Ter (c.2977C>T); Zygosity=Homozygous (Cosmic-CLP=906797; DepMap=ACH-000896).
  • Mutation; HGNC; HGNC:6974; MDM4; Simple; p.Ser161Ter (c.482C>G); Zygosity=Heterozygous (Cosmic-CLP=906797; DepMap=ACH-000896).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=24035680).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile162Asn (c.485T>A); ClinVar=VCV001408611; Zygosity=Heterozygous (Cosmic-CLP=906797; DepMap=ACH-000896).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu336Ter (c.1006G>T); Zygosity=Heterozygous (Cosmic-CLP=906797; DepMap=ACH-000896).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01
HLA-BB*27:05,40:01
HLA-CC*02:02,03:04
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.52
Native American0
East Asian, North1.95
East Asian, South0
South Asian0
European, North64.01
European, South32.52
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A666 (RO-H85-1)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=906797; DSMZ=ACC-414

Markers:
AmelogeninX,Y
CSF1PO12
D2S133824
D3S135816
D5S81811
D7S8208,11
D8S117912,13
D13S31711,14
D16S53911
D18S5113
D19S43312
D21S1128,30
FGA20,22
Penta D10,11
Penta E13
TH017
TPOX8
vWA18,21

Run an STR similarity search on this cell line
Publications

PubMed=944089
Arthur Y. Elliott, David Leigh Bronson, Nell Stein, Elwin Eugene Fraley;
In vitro cultivation of epithelial cells derived from tumors of the human urinary tract.
Cancer Res. 36:365-369(1976)

DOI=10.1016/B978-0-12-043050-5.50049-4
Arthur Y. Elliott, David Leigh Bronson, Jaroslov Cervenka, Patrick H. Cleveland, Elwin Eugene Fraley;
Establishment and characterization of epithelial cell cultures from tumors of the human urinary tract.
(In book chapter) Cell culture and its application; Acton, Ronald T. (eds.); pp.711-728; Academic Press; New York; USA (1977)

PubMed=66978
Arthur Y. Elliott, David Leigh Bronson, Jaroslov Cervenka, Nell Stein, Elwin Eugene Fraley;
Properties of cell lines established from transitional cell cancers of the human urinary tract.
Cancer Res. 37:1279-1289(1977)

PubMed=571047
Jorgen Fogh;
Cultivation, characterization, and identification of human tumor cells with emphasis on kidney, testis, and bladder tumors.
Natl. Cancer Inst. Monogr. 49:5-9(1978)

PubMed=748774
Arthur Y. Elliott, David Leigh Bronson, Elwin Eugene Fraley;
Transitional cell cancer: establishment and characterization of cell lines.
Natl. Cancer Inst. Monogr. 49:23-24(1978)

PubMed=6244232
Richard D. Williams;
Human urologic cancer cell lines.
Invest. Urol. 17:359-363(1980)

PubMed=7459858
Monique Rousset, Alain Zweibaum, Jorgen Fogh;
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=6220172
Nicholas C. Dracopoli, Jorgen Fogh;
Polymorphic enzyme analysis of cultured human tumor cell lines.
J. Natl. Cancer Inst. 70:469-476(1983)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=8873383; DOI=10.1007/BF00295899
Walter M. Stadler, Olufunmilayo I. Olopade;
The 9p21 region in bladder cancer cell lines: large homozygous deletion inactivate the CDKN2, CDKN2B and MTAP genes.
Urol. Res. 24:239-244(1996)

PubMed=15846775; DOI=10.1002/gcc.20166
Sarah V. Williams, Jacqui Adams, Jane Coulter, Brenda M. Summersgill, Janet M. Shipley, Margaret A. Knowles;
Assessment by M-FISH of karyotypic complexity and cytogenetic evolution in bladder cancer in vitro.
Genes Chromosomes Cancer 43:315-328(2005)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa, Jonathan Hinton, Ciara Fahey ...Show all 22 authors... , Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera, Rui Wang, Angela Tam ...Show all 22 authors... , Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy, Manway Liu, Lauren Murray ...Show all 61 authors... , Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23401075; DOI=10.1002/path.4176
Ya-Nan Guo, Yvonne Chekaluk, Jian-Ming Zhang, Jin-Yan Du, Nathanael S. Gray, Chin-Lee Wu, David Joseph Kwiatkowski;
TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.
J. Pathol. 230:17-27(2013)

PubMed=24367658; DOI=10.1371/journal.pone.0084411; PMCID=PMC3867501
Rebecca L. Ross, Julie E. Burns, Claire F. Taylor, Paul Mellor, Deborah H. Anderson, Margaret A. Knowles;
Identification of mutations in distinct regions of p85 alpha in urothelial cancer.
PLoS ONE 8:e84411.1-e84411.11(2013)

PubMed=24035680; DOI=10.1016/j.eururo.2013.08.057
Carolyn D. Hurst, Fiona M. Platt, Margaret A. Knowles;
Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine.
Eur. Urol. 65:367-369(2014)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer, Patricia Greninger, Ewald van Dyk ...Show all 39 authors... , Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350
Tahlita C.M. Zuiverloon, Florus C. de Jong, James C. Costello, Dan Theodorescu;
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu, Alexander Y. Andreev-Drakhlin, Jaegil Kim ...Show all 68 authors... , Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker, Jennifer Koh, Howard Lightfoot ...Show all 32 authors... , Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ATCC; HTB-110 - Discontinued
DSMZ; ACC-414
Cell line databases/resources CLO; CLO_0001450
cancercelllines; CVCL_1049
Cell_Model_Passport; SIDM00983
Cosmic-CLP; 906797
DepMap; ACH-000896
DSMZCellDive; ACC-414
IGRhCellID; 647V
LINCS_HMS; 50002
LINCS_LDP; LCL-1708
Biological sample resources BioSample; SAMN03473588
BioSample; SAMN10989565
CRISP screens repositories BioGRID_ORCS_Cell_line; 500
Chemistry resources ChEMBL-Cells; CHEMBL3308704
ChEMBL-Targets; CHEMBL1075384
GDSC; 906797
PharmacoDB; 647V_25_2019
PubChem_Cell_line; CVCL_1049
Encyclopedic resources Wikidata; Q51951823
Experimental variables resources EFO; EFO_0002098
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM827156
GEO; GSM886842
GEO; GSM887906
GEO; GSM1374377
GEO; GSM1669570
Polymorphism and mutation databases Cosmic; 906797
Cosmic; 928822
Cosmic; 1046676
Cosmic; 1285105
Cosmic; 1286005
Cosmic; 1927309
Cosmic; 2050429
Cosmic; 2057435
Cosmic; 2444239
Cosmic; 2685932
IARC_TP53; 21152
LiGeA; CCLE_044
Progenetix; CVCL_1049
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number41