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Cellosaurus RPMI-4788 (CVCL_0U46)

[Text version]
Cell line name RPMI-4788
Synonyms RPMI 4788; RPMI4788; R.P.M.I. #4788; Roswell Park Memorial Institute 4788
Accession CVCL_0U46
Resource Identification Initiative To cite this cell line use: RPMI-4788 (RRID:CVCL_0U46)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=23136038). Was originally thought to originate from the pleural fluid of a 73 year old female patient with a colon adenocarcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00387.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1309

Markers:
AmelogeninX
CSF1PO9,10
D5S81811,12
D7S8208,12
D13S31713.3
D16S53910
TH017
TPOX8,12
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=14082866
George Eugene Moore, David Mount, G. Tara, N. Schwartz;
Growth of human tumor cells in suspension cultures.
Cancer Res. 23:1735-1741(1963)

PubMed=2504864
Hiromi Iwagaki, Sadanori Fuchimoto, Sigeo Shiiki, Mikio Miyake, Kunzo Orita;
Monitoring the effect of an anti-cancer drug on RPMI 4788 cells by a membrane potential probe, dis-C3-(5).
J. Med. 20:135-141(1989)

PubMed=23136038; DOI=10.1002/ijc.27931
Amanda Capes-Davis, Yvonne A. Reid, Margaret C. Kline, Douglas R. Storts, Ethan Strauss, Wilhelm Gerhard Dirks, Hans Gunther Drexler, Roderick A.F. MacLeod, Gregory R. Sykes, Arihiro Kohara, Yukio Nakamura ...Show all 22 authors... , Eugene Elmore, Raymond Whiting Nims, Christine Alston-Roberts, Rita Barallon, Georgyi V. Los, Roland Mario Nardone, Paul J. Price, Anton Steuer, Jim A. Thomson, John R.W. Masters, Liz Kerrigan; Show fewer authors
Match criteria for human cell line authentication: where do we draw the line?
Int. J. Cancer 132:2510-2519(2013)

Cross-references
Cell line collections (Providers) JCRB; JCRB1309 - Discontinued
JCRB; NIHS0553 - Discontinued
Biological sample resources BioSample; SAMN03151753
BioSample; SAMN03472398
Encyclopedic resources Wikidata; Q54951187
Entry history
Entry creation08-Jul-2015
Last entry update10-Apr-2025
Version number17