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Cellosaurus OMT-1 (CVCL_0G03)

[Text version]
Cell line name OMT-1
Synonyms OMT
Accession CVCL_0G03
Resource Identification Initiative To cite this cell line use: OMT-1 (RRID:CVCL_0G03)
Comments Population: Japanese.
Characteristics: IL2 dependent. But can survive without IL2 for several weeks (PubMed=9596675).
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Disease Adult T-cell leukemia/lymphoma (NCIt: C3184)
Adult T-cell leukemia/lymphoma (ORDO: Orphanet_86875)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=9596675; DOI=10.1182/blood.V91.11.4265
Yamada Y., Sugawara K., Hata T., Tsuruta K., Moriuchi R., Maeda T., Atogami S., Murata K., Fujimoto K., Kohno T., Tsukasaki K., Tomonaga M., Hirakata Y.-i., Kamihira S.
Interleukin-15 (IL-15) can replace the IL-2 signal in IL-2-dependent adult T-cell leukemia (ATL) cell lines: expression of IL-15 receptor alpha on ATL cells.
Blood 91:4265-4272(1998)

PubMed=10570904; DOI=10.1007/s100380050178
Ariyama Y., Mori T., Shinomiya T., Sakabe T., Fukuda Y., Kanamaru A., Yamada Y., Isobe M., Seto M., Nakamura Y., Inazawa J.
Chromosomal imbalances in adult T-cell leukemia revealed by comparative genomic hybridization: gains at 14q32 and 2p16-22 in cell lines.
J. Hum. Genet. 44:357-363(1999)

PubMed=19220422; DOI=10.1111/j.1600-0609.2009.01211.x
Kamihira S., Terada C., Sasaki D., Yanagihara K., Tsukasaki K., Hasegawa H., Yamada Y.
Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations.
Eur. J. Haematol. 82:301-307(2009)

PubMed=19710698; DOI=10.1038/leu.2009.171
Hasegawa H., Yamada Y., Iha H., Tsukasaki K., Nagai K., Atogami S., Sugahara K., Tsuruda K., Ishizaki A., Kamihira S.
Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells.
Leukemia 23:2090-2101(2009)

Cross-references
Cell line databases/resources CGH-DB; 9027-4
Encyclopedic resources Wikidata; Q54936379
Polymorphism and mutation databases IARC_TP53; 27002
Entry history
Entry creation10-Apr-2015
Last entry update29-Jun-2023
Version number9