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Cellosaurus OMT-1 (CVCL_0G03)

[Text version]
Cell line name OMT-1
Synonyms OMT
Accession CVCL_0G03
Resource Identification Initiative To cite this cell line use: OMT-1 (RRID:CVCL_0G03)
Comments Population: Japanese.
Characteristics: IL2 dependent. But can survive without IL2 for several weeks (PubMed=9596675).
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Disease Adult T-cell leukemia/lymphoma (NCIt: C3184)
Adult T-cell leukemia/lymphoma (ORDO: Orphanet_86875)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=9596675; DOI=10.1182/blood.V91.11.4265
Yasuaki Yamada, Kazuyuki Sugawara, Tomoko Hata, Kazuto Tsuruta, Ryouzou Moriuchi, Takahiro Maeda, Sunao Atogami, Ken Murata, Kenshi Fujimoto, Tomoko Kohno, Kunihiro Tsukasaki ...Show all 14 authors... , Masao Tomonaga, Yo-ichi Hirakata, Shimeru Kamihira; Show fewer authors
Interleukin-15 (IL-15) can replace the IL-2 signal in IL-2-dependent adult T-cell leukemia (ATL) cell lines: expression of IL-15 receptor alpha on ATL cells.
Blood 91:4265-4272(1998)

PubMed=10570904; DOI=10.1007/s100380050178
Yoji Ariyama, Toshiki Mori, Takashi Shinomiya, Tomoya Sakabe, Yoji Fukuda, Akihisa Kanamaru, Yasuaki Yamada, Masaharu Isobe, Masao Seto, Yusuke Nakamura, Johji Inazawa;
Chromosomal imbalances in adult T-cell leukemia revealed by comparative genomic hybridization: gains at 14q32 and 2p16-22 in cell lines.
J. Hum. Genet. 44:357-363(1999)

PubMed=19220422; DOI=10.1111/j.1600-0609.2009.01211.x
Shimeru Kamihira, Chiharu Terada, Daisuke Sasaki, Katsunori Yanagihara, Kunihiro Tsukasaki, Hiroo Hasegawa, Yasuaki Yamada;
Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations.
Eur. J. Haematol. 82:301-307(2009)

PubMed=19710698; DOI=10.1038/leu.2009.171
Hiroo Hasegawa, Yasuaki Yamada, Hidekatsu Iha, Kunihiro Tsukasaki, K. Nagai, Sunao Atogami, K. Sugahara, Kazuto Tsuruda, Akiko Ishizaki, Shimeru Kamihira;
Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells.
Leukemia 23:2090-2101(2009)

Cross-references
Cell line databases/resources CGH-DB; 9027-4
Encyclopedic resources Wikidata; Q54936379
Polymorphism and mutation databases IARC_TP53; 27002
Entry history
Entry creation10-Apr-2015
Last entry update29-Jun-2023
Version number9