Cellosaurus logo
expasy logo

Cellosaurus CML-6M (CVCL_0D24)

[Text version]
Cell line name CML-6M
Synonyms CML_6M; CML6M
Accession CVCL_0D24
Resource Identification Initiative To cite this cell line use: CML-6M (RRID:CVCL_0D24)
Comments Part of: FACC canine tumor cell line panel.
Characteristics: Pigmented.
Doubling time: 15 hours (PubMed=27257868).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; VGNC; 43761; NF1; Simple; p.Pro1599fs (c.4795delCinsTT); Zygosity=Heterozygous (PubMed=31175136).
Disease Canine melanoma (NCIt: C120298)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Mixed breed.
Hierarchy Children:
Sex of cell Sex unspecified
Age at sampling 8Y
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Dog FHC2010235,239
Dog FHC2054151
Dog FHC2079275
Dog PEZ1119,127
Dog PEZ12277,297
Dog PEZ20172,180
Dog PEZ3127,134
Dog PEZ5103
Dog PEZ6179
Dog PEZ8236,240

Run an STR similarity search on this cell line

Wolfe L.G., Oliver J.L. III, Smith B.B., Toivio-Kinnucan M.A., Powers R.D., Brawner W.R., Henderson R.A., Hankes G.H.
Biologic characterization of canine melanoma cell lines.
Am. J. Vet. Res. 48:1642-1648(1987)

Ahern T.E., Bird R.C., Church Bird A.E., Wolfe L.G.
Overexpression of c-erbB-2 and c-myc but not c-ras, in canine melanoma cell lines, is associated with metastatic potential in nude mice.
Anticancer Res. 13:1365-1371(1993)

PubMed=15965647; DOI=10.1007/s00262-005-0025-6
Alexander A.N., Huelsmeyer M.K., Mitzey A., Dubielzig R.R., Kurzman I.D., MacEwen E.G., Vail D.M.
Development of an allogeneic whole-cell tumor vaccine expressing xenogeneic gp100 and its implementation in a phase II clinical trial in canine patients with malignant melanoma.
Cancer Immunol. Immunother. 55:433-442(2006)

PubMed=21908323; DOI=10.1177/1040638711408064
O'Donoghue L.E., Rivest J.P., Duval D.L.
Polymerase chain reaction-based species verification and microsatellite analysis for canine cell line validation.
J. Vet. Diagn. Invest. 23:780-785(2011)

PubMed=22901430; DOI=10.1016/j.jcpa.2012.07.001
Chon E., Thompson V., Schmid S., Stein T.J.
Activation of the canonical Wnt/beta-catenin signalling pathway is rare in canine malignant melanoma tissue and cell lines.
J. Comp. Pathol. 148:178-187(2013)

PubMed=23410087; DOI=10.1111/vco.12019
Wilson-Robles H.M., Daly M., Pfent C., Sheppard S.
Identification and evaluation of putative tumour-initiating cells in canine malignant melanoma cell lines.
Vet. Comp. Oncol. 13:60-69(2015)

PubMed=27257868; DOI=10.1371/journal.pone.0156689
Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:E0156689-E0156689(2016)

PubMed=27197945; DOI=10.1111/vco.12192
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

Encyclopedic resources Wikidata; Q54813799
Gene expression databases GEO; GSM1974782
Entry history
Entry creation10-Apr-2015
Last entry update29-Jun-2023
Version number12