Cellosaurus logo
expasy logo

Cellosaurus CML-6M (CVCL_0D24)

[Text version]
Cell line name CML-6M
Synonyms CML_6M; CML6M
Accession CVCL_0D24
Resource Identification Initiative To cite this cell line use: CML-6M (RRID:CVCL_0D24)
Comments Part of: FACC canine tumor cell line panel.
Characteristics: Pigmented.
Doubling time: 15 hours (PubMed=27257868).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; VGNC; VGNC:43761; NF1; Simple; p.Pro1599fs (c.4795delCinsTT); Zygosity=Heterozygous (PubMed=31175136).
Disease Canine melanoma (NCIt: C120298)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Breed/subspecies: Mixed breed; VBO=VBO_0200902.
Hierarchy Children:
CVCL_IZ10 (CML-6MC2)
Sex of cell Sex unspecified
Age at sampling 8Y
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Markers:
Dog FHC2010235,239
Dog FHC2054151
Dog FHC2079275
Dog PEZ1119,127
Dog PEZ12277,297
Dog PEZ20172,180
Dog PEZ3127,134
Dog PEZ5103
Dog PEZ6179
Dog PEZ8236,240

Run an STR similarity search on this cell line
Publications

PubMed=3434911; DOI=10.2460/ajvr.1987.48.11.1642
Lauren G. Wolfe, Julian Linwood Oliver 3rd, Bonnie Buxton Smith, Maria A. Toivio-Kinnucan, Robert D. Powers, William R. Brawner, Ralph A. Henderson, Gerald H. Hankes;
Biologic characterization of canine melanoma cell lines.
Am. J. Vet. Res. 48:1642-1648(1987)

PubMed=8239507
Terry E. Ahern, R. Curtis Bird, Allison E. Church Bird, Lauren G. Wolfe;
Overexpression of c-erbB-2 and c-myc but not c-ras, in canine melanoma cell lines, is associated with metastatic potential in nude mice.
Anticancer Res. 13:1365-1371(1993)

PubMed=15965647; DOI=10.1007/s00262-005-0025-6; PMCID=PMC11031070
Andrew N. Alexander, Michael K. Huelsmeyer, Ann Mitzey, Richard R. Dubielzig, Ilene D. Kurzman, E. Gregory MacEwen, David M. Vail;
Development of an allogeneic whole-cell tumor vaccine expressing xenogeneic gp100 and its implementation in a phase II clinical trial in canine patients with malignant melanoma.
Cancer Immunol. Immunother. 55:433-442(2006)

PubMed=21908323; DOI=10.1177/1040638711408064
Liza E. O'Donoghue, Jason P. Rivest, Dawn L. Duval;
Polymerase chain reaction-based species verification and microsatellite analysis for canine cell line validation.
J. Vet. Diagn. Invest. 23:780-785(2011)

PubMed=22901430; DOI=10.1016/j.jcpa.2012.07.001; PMCID=PMC3535688
Esther Chon, Victoria Thompson, Simone Schmid, Timothy J. Stein;
Activation of the canonical Wnt/beta-catenin signalling pathway is rare in canine malignant melanoma tissue and cell lines.
J. Comp. Pathol. 148:178-187(2013)

PubMed=23410087; DOI=10.1111/vco.12019
Heather M. Wilson-Robles, Maria Daly, Catherine Pfent, Sabine Sheppard-Olivares;
Identification and evaluation of putative tumour-initiating cells in canine malignant melanoma cell lines.
Vet. Comp. Oncol. 13:60-69(2015)

PubMed=27257868; DOI=10.1371/journal.pone.0156689; PMCID=PMC4892608
Junko Maeda, Coral Eva Froning, Colleen A. Brents, Barbara J. Rose, Douglas H. Thamm, Takamitsu A. Kato;
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:e0156689.1-e0156689.18(2016)

PubMed=27197945; DOI=10.1111/vco.12192; PMCID=PMC5656225
Jared S. Fowles, Deanna D. Dailey, Daniel L. Gustafson, Douglas H. Thamm, Dawn L. Duval;
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748
Sunetra Das, Rupa Idate, Kathryn E. Cronise, Daniel L. Gustafson, Dawn L. Duval;
Identifying candidate druggable targets in canine cancer cell lines using whole-exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

Cross-references
Encyclopedic resources Wikidata; Q54813799
Gene expression databases GEO; GSM1974782
Entry history
Entry creation10-Apr-2015
Last entry update10-Apr-2025
Version number15