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Cellosaurus SKOV3.ip1 (CVCL_0C84)

[Text version]
Cell line name SKOV3.ip1
Synonyms SKOV3-ip1; Skov3-ip1; SKOV3ip1; SKOV3IP1; SKOV3IP
Accession CVCL_0C84
Resource Identification Initiative To cite this cell line use: SKOV3.ip1 (RRID:CVCL_0C84)
Comments Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Omics: Deep proteome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Web pages https://tcpaportal.org/mclp/

Yu D.-H., Wolf J.K., Scanlon M., Price J.E., Hung M.-C.
Enhanced c-erbB-2/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A.
Cancer Res. 53:891-898(1993)

PubMed=23552738; DOI=10.1038/oncsis.2012.22
Lee J., Bartholomeusz C., Krishnamurthy S., Liu P., Saso H., LaFortune T.A., Hortobagyi G.N., Ueno N.T.
PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking beta-catenin.
Oncogenesis 1:e22.1-e22.11(2012)

PubMed=27561551; DOI=10.1038/ncomms12645
Coscia F., Watters K.M., Curtis M., Eckert M.A., Chiang C.Y., Tyanova S., Montag A., Lastra R.R., Lengyel E., Mann M.
Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.
Nat. Commun. 7:12645.1-12645.14(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cell line databases/resources cancercelllines; CVCL_0C84
Anatomy/cell type resources BTO; BTO:0006557
Encyclopedic resources Wikidata; Q54954770
Proteomic databases PRIDE; PXD003668
Entry history
Entry creation10-Apr-2015
Last entry update05-Oct-2023
Version number18