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Cellosaurus INA-6.Tu1 (CVCL_0C40)

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Cell line name INA-6.Tu1
Synonyms Tu1
Accession CVCL_0C40
Resource Identification Initiative To cite this cell line use: INA-6.Tu1 (RRID:CVCL_0C40)
Comments Population: Caucasian.
Characteristics: Produces IgG kappa.
Characteristics: IL6 dependent.
Characteristics: Derived from a tumor that grew in a SCID mouse.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys132Met (c.395A>T); ClinVar=VCV000376629; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln331Ter (c.991C>T); ClinVar=VCV000922893; Zygosity=Heterozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5209 (INA-6)
Sex of cell Male
Age at sampling 80Y
Category Cancer cell line
Publications

PubMed=19621390; DOI=10.1002/ijc.24758
Andreas Guenther, Sharon Gordon, Markus Tiemann, Renate Burger, Frank Bakker, Jon R. Green, Wolfgang Baum, Anke J. Roelofs, Michael J. Rogers, Martin Gramatzki;
The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation.
Int. J. Cancer 126:239-246(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_0C40
Encyclopedic resources Wikidata; Q54897701
Entry history
Entry creation10-Apr-2015
Last entry update14-Aug-2025
Version number17