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Cellosaurus HROC18 (CVCL_0B45)

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Cell line name HROC18
Synonyms HROC 18
Accession CVCL_0B45
Resource Identification Initiative To cite this cell line use: HROC18 (RRID:CVCL_0B45)
Comments From: Linnebacher, Michael; University of Rostock; Rostock; Germany.
Population: Caucasian.
Doubling time: 35 +- 7.2 hours (PubMed=25574089).
Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Cecum; UBERON=UBERON_0001153.
HLA typing Source: CLS=300808
Class I
HLA-AA*01:01:01,02:01:01
HLA-BB*08:01:01,15:24:01
HLA-CC*07:01:01
Class II
HLA-DPDPB1*01:01,04:01
HLA-DQDQA1*05:01:01,05:05:01
DQB1*02:01:01,03:01:01
HLA-DRDRB1*03:01:01,13:03:01
Disease Cecum adenocarcinoma (NCIt: C5543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_C0UD ! B-LCL-HROC18
Sex of cell Female
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): CLS=300808; Direct_author_submission; PubMed=25926053

Markers:
AmelogeninX
CSF1PO12
D5S8189,11
D7S8208,11
D13S31711
D16S53912,13
D21S1130,33.2
TH017,8
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=24647592; DOI=10.3892/or.2014.3097
Maja Huhns, Tareq Salem, Bjorn Schneider, Mathias Krohn, Michael Linnebacher, Friedrich Prall;
PTEN mutation, loss of heterozygosity, promoter methylation and expression in colorectal carcinoma: two hits on the gene?
Oncol. Rep. 31:2236-2244(2014)

PubMed=25309914; DOI=10.1155/2014/568693; PMCID=PMC4182691
Falko Lange, Benjamin Franz, Claudia Maletzki, Michael Linnebacher, Maja Huhns, Robert Jaster;
Biological and molecular effects of small molecule kinase inhibitors on low-passage human colorectal cancer cell lines.
BioMed Res. Int. 2014:568693.1-568693.13(2014)

PubMed=25574089; DOI=10.3748/wjg.v21.i1.164; PMCID=PMC4284332
Claudia Maletzki, Michael Gock, Martin Randow, Ernst Klar, Maja Huhns, Friedrich Prall, Michael Linnebacher;
Establishment and characterization of cell lines from chromosomal instable colorectal cancer.
World J. Gastroenterol. 21:164-176(2015)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=31601052; DOI=10.3390/cancers11101520; PMCID=PMC6826890
Christina Susanne Mullins, Bianca Micheel, Stephanie Matschos, Matthias Leuchter, Florian Burtin, Mathias Krohn, Maja Huhns, Ernst Klar, Friedrich Prall, Michael Linnebacher;
Integrated biobanking and tumor model establishment of human colorectal carcinoma provides excellent tools for preclinical research.
Cancers (Basel) 11:1520.1-1520.18(2019)

Cross-references
Cell line collections (Providers) CLS; 300808
Encyclopedic resources Wikidata; Q54895248
Gene expression databases GEO; GSM1448095
Polymorphism and mutation databases Cosmic; 2151360
Cosmic; 2324288
Entry history
Entry creation10-Apr-2015
Last entry update10-Apr-2025
Version number20